Extracellular Matrix News Volume 15.12 | Apr 4 2024

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    2024-04-04 | ECM 15.12


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 15.12 – 4 April, 2024
    TOP STORY

    Harnessing Developmental Dynamics of Spinal Cord Extracellular Matrix Improves Regenerative Potential of Spinal Cord Organoids

    Scientists found that early developmental spinal cord had higher levels of ECM proteins associated with neural development and axon growth, but fewer inhibitory proteoglycans, compared to those of adult spinal cord.
    [Cell Stem Cell]

    AbstractGraphical Abstract
    A Labroots 2021 Webinar: iPSCs As Models, Part 1: What Are Induced Pluripotent Stem Cells and How Do You Use Them?, presented by Dr. Anjana Nityanandam, Director of the Human Stem Cell Lab core facility at St. Jude Children’s Research Hospital. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Zinc–Iron Bimetallic Peroxides Modulate the Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Enhanced Breast Cancer Immunotherapy Therapy

    To sensitize patients to breast cancer immunotherapy, hyaluronic acid-modified zinc peroxide–iron nanocomposites were synthesized to remodel the stromal microenvironment and increased tumor immunogenicity.
    [ACS Nano]

    AbstractGraphical Abstract

    Nanoparticle-Mediated Multiple Modulation of Bone Microenvironment To Tackle Osteoarthritis

    Investigators reported the design of a reactive oxygen species-responsive nanomedicine formulation based on fibronectin-coated polymer nanoparticles loaded with azabisdimethylphoaphonate-terminated phosphorus dendrimers.
    [ACS Nano]

    AbstractGraphical Abstract

    Age-Progressive Interplay of HSP-Proteostasis, ECM-Cell Junctions and Biomechanics Ensures C. elegans Astroglial Architecture

    Scientists combined large-scale genetics with manipulation of genes, cells, and their environment, quantitative imaging of cellular/subcellular features, tissue material properties and ECM.
    [Nature Communications]

    Full Article

    Targeting the Nuclear Long Noncoding Transcript LSP1P5 Abrogates Extracellular Matrix Component Deposition by Trans-Upregulating CEBPA in Keloids

    Investigators identified a long noncoding transcript, namely, lymphocyte-specific protein 1 pseudogene 5 (LSP1P5), that modulated ECM component deposition in keloids.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Force-Induced Tail-Autotomy Mitochondrial Fission and Biogenesis of Matrix-Excluded Mitochondrial-Derived Vesicles for Quality Control

    Utilizing an optogenetic mitochondria-specific mechanostimulator, the authors revealed that mechanical tensile force drove tail-autotomy fission.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Label-Free Quantification of Imaging Features in the Extracellular Matrix of Left and Right-Sided Colon Cancer Tissues

    Investigators employed 2-photon laser scanning microscopy to visualize the intrinsic second-harmonic generation signal emitted by collagen fibers in the heterogeneous ECM of human colon tumor tissues.
    [Scientific Reports]

    Full Article
    Learn more about cGMP-manufactured StemSpan™-ACF Without Phenol Red for culturing hematopoietic cell therapy products
    REVIEWS

    Model-Based Modular Hydrogel Design

    The authors present a model-based modular hydrogel design framework that is application-driven and considers clinical translation early in the design process.
    [Nature Reviews Bioengineering]

    Abstract
    INDUSTRY AND POLICY NEWS

    Australian Government Commits $5.7 Million to Drive Innovative Cancer Research Initiatives

    The Australia Federal Minister for Health and Aged Care Mark Butler has announced a government pledge of $5.7 million in funding to cancer research to support 15 grants through Cancer Australia’s Priority-driven Collaborative Cancer Research Scheme.
    [Proactive]

    Press Release

    American Institute for Medical and Biological Engineering College of Fellows

    The American Institute for Medical and Biological Engineering has inducted Aijun Wang, a professor of biomedical engineering, into its esteemed College of Fellows for his outstanding contributions to stem cell engineering and tissue regeneration application.
    [UC Davis]

    Press Release
    FEATURED EVENT

    Myeloid Targeting Strategies for Cancer Treatment

    May 6 – 9, 2024
    Killarney, Ireland

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    JOB OPPORTUNITIES

    Research Associate – Bioprinting, Biomaterials and Tissue Engineering

    New York University Abu Dhabi – Abu Dhabi, United Arab Emirates

    Bioinformatician – Cell-Matrix Biology

    The University of Manchester – Manchester, England, United Kingdom

    Postdoctoral Positions – Biotechnology

    Sapienza University – Rome, Italy

    Postdoctoral Position – Pancreatic Cancer Research

    Umeå University – Umeå, Sweden

    Postdoctoral Position – Pancreatic Cancer Research

    Umeå University – Umeå, Sweden

    > See All Jobs

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