 | | Vol. 15.13 – 11 April, 2024 |
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| In immune-hot adenocarcinomas, spatial niches of T cells and macrophages increased with clonal neoantigen burden, whereas such an increase was observed for niches of plasma and B cells in immune-excluded squamous cell carcinomas.
[Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that early developmental spinal cord had higher levels of ECM proteins associated with neural development and axon growth, but fewer inhibitory proteoglycans, compared to those of adult spinal cord.
[Cell Stem Cell] |
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| Researchers showed that transient sparse cell death in the mouse fetal cartilage was repaired postnatally, via a two-step process. During injury, progression of chondroprogenitors towards more differentiated states is delayed, leading to altered cartilage cytoarchitecture and impaired bone growth.
[Nature Communications] |
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| Investigators showed in mammary stromal fibroblasts that loss of the receptor tyrosine kinase (RTK) negative feedback regulators encoded by Spry1, Spry2, and Spry4 causes upregulation of signaling in multiple RTK pathways and increased extracellular matrix remodeling.
[Cell Death & Disease] |
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| The authors introduced a novel human decellularized placenta-derived ECM hydrogel and, combined with a new induction protocol, successfully construct human spinal cord organoids.
[ACS Biomaterials Science & Engineering] |
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| Microarray-based transcriptome analysis of the cartilage tissues of four adults and chondrocytes of 12 children showed that the median expression levels of SHOX, a growth gene in the pseudoautosomal region, were higher in male samples than in female samples.
[Scientific Reports] |
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SimuCell3D: Three-Dimensional Simulation of Tissue Mechanics with Cell Polarization | Researchers presented SimuCell3D, an efficient open-source program to simulate large tissues in three dimensions with subcellular resolution, growth, proliferation, extracellular matrix, fluid cavities, nuclei and non-uniform mechanical properties, as found in polarized epithelia.
[Nature Computational Science] |
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Mechanical State Transitions in the Regulation of Tissue Form and Function | Scientists focus on the biological basis of tissue-scale mechanical state transitions, how they emerge from molecular and cellular interactions, and their roles in organismal development, homeostasis, regeneration and disease.
[Nature Reviews Molecular Cell Biology] |
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Induced Pluripotent Stem Cells in Cartilage Tissue Engineering: A Literature Review | Investigators focus on chondrogenic differentiation and 3D bioprinting technologies using hiPSCS, suggesting them as a viable source for successful tissue engineering.
[Bioscience Reports] |
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Federal Agency Supports Research to Improve Nanofiber Production | A team of engineers from the Rowan-Virtua School of Translational Biomedical Engineering & Sciences and the Henry M. Rowan College of Engineering has developed novel technology for fabricating aligned nanofibers in continuous rolls of material.
[Rowan University] |
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ISCT 2024 | May 29 – June 1, 2024
Vancouver, British Columbia, Canada |
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| | Boston University – Boston, Massachusetts, United States |
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| | University of Oregon – Eugene, Oregon, United States |
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| | The University of Manchester – Manchester, England, United Kingdom |
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| | New York University Abu Dhabi – Abu Dhabi, United Arab Emirates |
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| | Sapienza University – Rome, Italy |
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