 | | Vol. 15.14 – 18 April, 2024 |
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| Researchers observed that 2D stiffness micropatterns induced cardiac fibroblasts (cFBs) anisotropic alignment. cFBs exhibited organized alignment also in response to 3D stiffness macropatterns, dependent on the stimulus timing and temporally followed by ECM co-alignment.
[Biofabrication] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators validated the pivotal role of activating transcription factor 5 (ATF5) in upregulating the UPRmt, mitigating IL-1β-induced inflammation and mitochondrial dysfunction, and promoting balanced metabolism in articular cartilage ECM, proving its potential as a promising therapeutic target for osteoarthritis.
[ACS Applied Materials & Interfaces] |
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| A novel collagen crosslinking agent (CE) was synthesized through a reaction involving chitosan quaternary ammonium salt with 1,4-butanediol diglycidyl ether. Compared to collagen crosslinked with glutaraldehyde, the CE-crosslinked collagen implant exhibited notable stability and durability.
[Journal Of Materials Chemistry B] |
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| Human pulmonary fibroblasts were transfected with miR-29a-3p, and RT-qPCR, immunostaining, and western blotting were performed to determine the expression of DNA methyltransferase (DNMT) 3A and extracellular matrix collagen-1 and fibronectin-1 levels.
[Biomedicine & Pharmacotherapy] |
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| Scientists suggested that aflatoxin B1 damaged the cell morphology, induced oxidative damage and apoptosis, and degraded ECM components, in turn inhibiting myoblast development by activating the p38MAPK/urokinase-type plasminogen activator/matrix metalloproteinase/ECM signaling pathway.
[Ecotoxicology And Environmental Safety] |
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| Knocking down Nogo-B caused the downregulation of pro-fibrotic genes and inhibited the viability of hepatic stellate cells. Nogo-B knockdown prevented CCL4-induced fibrosis, accompanied by downregulation of the extracellular matrix.
[Tissue Engineering And Regenerative Medicine] |
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| Scientists delve into the complex connections between breast cancer treatment response, underlying epigenetic changes, and vital interactions within the tumor microenvironment.
[Biomedicine & Pharmacotherapy] |
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| Europe launched the most clinical trials for cystic fibrosis treatments, while North America leads in those for acute myeloid leukemia (AML), according to a pair of new global trial landscape reports announced by contract research organization Novotech.
[Fierce Biotech] |
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| May 6 – 9, 2024
Killarney, Ireland |
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| | City of Hope – Duarte, California, United States |
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| | Boston University – Boston, Massachusetts, United States |
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| | University of Oregon – Eugene, Oregon, United States |
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| | The University of Manchester – Manchester, England, United Kingdom |
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| | New York University Abu Dhabi – Abu Dhabi, United Arab Emirates |
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