Extracellular Matrix News Volume 15.15 | Apr 25 2024

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    2024-04-25 | ECM 15.15


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 15.15 – 25 April, 2024
    TOP STORY

    Engineering Large-Scale Self-Mineralizing Bone Organoids with Bone Matrix-Inspired Hydroxyapatite Hybrid Bioinks

    Bioprinted scaffolds facilitated the long-term cultivation and progressive maturation of extensive bioprinted bone organoids, fostered multicellular differentiation, and offered valuable insights into the initial stages of bone formation.
    [Advanced Materials]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Injectable In Situ Gelling Methylcellulose-Based Hydrogels for Bone Tissue Regeneration

    In vitro biological characterization revealed the beneficial impact of calcium phosphate (CaP) and CaP modified with graphene oxide, indicating their potential in promoting cell adhesion, proliferation and osteogenic differentiation.
    [Journal Of Materials Chemistry B]

    Full ArticleGraphical Abstract

    A Highly Biocompatible CE-Crosslinked Collagen Implant with Exceptional Anti-Calcification and Collagen Regeneration Capabilities for Aging Skin Rejuvenation

    A novel collagen crosslinking agent (CE) was synthesized through a reaction involving chitosan quaternary ammonium salt with 1,4-butanediol diglycidyl ether. Compared to collagen crosslinked with glutaraldehyde, the CE-crosslinked collagen implant exhibited notable stability and durability.
    [Journal Of Materials Chemistry B]

    AbstractGraphical Abstract

    Sophoridine Exerts Anti-Arthritic Effects on Fibroblast-Like Synoviocytes and Collagen-Induced Arthritis in Rats

    A collagen-induced arthritis rat model and tumor necrosis factor alpha-induced fibroblast-like synoviocytes were utilized to investigate the inhibitory effect of Sophoridine on hreumatoid arthritis.
    [Phytotherapy Research]

    Abstract

    Increased Uterine Arterial Tone, Stiffness and Remodeling with Augmented Matrix Metalloproteinase-1 and -7 in Uteroplacental Ischemia-Induced Hypertensive Pregnancy

    Scientists tested whether hypertensive pregnancy involved localized aberrations in uterine arterial tone, stiffness and remodeling by matrix metalloproteinases.
    [Biochemical Pharmacology]

    Abstract

    A Single Chain Variable Fragment Antibody (TN 64) Cognate to Fibronectin Type III Repeats Promotes Corneal Wound Healing by Inhibiting Fibrosis

    The authors showed that Tn64 bound to Tn fn repeats 3–5. Unlike other Tn fn domains, Tn fn 3–5 displayed no inhibition of fibronectin matrix assembly.
    [International Immunopharmacology]

    AbstractGraphical Abstract

    Characterization of TGFβ1-Induced Tendon-Like Structure in the Scaffold-Free Three-Dimensional Tendon Cell Culture System

    Researchers developed a scaffold-free, 3D tendon culture system using mouse tendon cells in a differentially adherent growth channel.
    [Scientific Reports]

    Full Article

    Resistance Training-Induced Changes in Muscle Proteolysis and Extracellular Matrix Remodeling Biomarkers in the Untrained and Trained States

    Scientists examined how proteolysis-related biomarkers and ECM remodeling factors respond to a bout of resistance training in the untrained and trained state.
    [European Journal Of Applied Physiology]

    Abstract
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    REVIEWS

    Engineering Approaches for Understanding Mechanical Memory in Cancer Metastasis

    Investigators explore the evolving mechanical landscape during metastasis, emphasizing the significance of mechanical memory and its influence on cell behavior.
    [APL Bioengineering]

    Full Article
    INDUSTRY AND POLICY NEWS

    U of T, Hospitals Launch Pilot Program to Boost Commercialization of Medical Innovations

    The University of Toronto (U of T) is collaborating with the University Health Network, the Hospital for Sick Children, and Sunnybrook Research Institute on a new program to leverage the expertise of entrepreneurs to advance the commercialization of emerging medical technologies and regenerative medicine research.
    [University of Toronto]

    Press Release

    Dr. David Greene Unveils Groundbreaking Scholarship: Pioneering Medical Minds

    Healthcare innovator Dr. David Greene announced the establishment of the esteemed Dr. David Greene Scholarship for Medical Students, aimed at fostering excellence and innovation in the medical community. This scholarship, valued at $1,000, presents a unique chance for undergraduate students to further their medical ambitions.
    [Business Insider]

    Press Release
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    JOB OPPORTUNITIES

    Research Specialist – Structure of the ECM

    Princeton University – Princeton, New Jersey, United States

    Staff Scientist – Extracellular Vesicle in Diabetes Treatment

    City of Hope – Duarte, California, United States

    Postdoctoral Researcher – Scleroderma

    Boston University – Boston, Massachusetts, United States

    Postdoctoral Scholar – Synthetic Extracellular Matrix

    University of Oregon – Eugene, Oregon, United States

    Bioinformatician – Cell-Matrix Biology

    The University of Manchester – Manchester, England, United Kingdom

    > See All Jobs

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