 | | Vol. 14.20 – 13 April, 2023 |
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| Researchers showed that the structure, biomechanics, and degree of advanced glycation end-product (AGE)-mediated crosslinking of the matrices can be recapitulated in collagen matrix crosslinked by AGE-products in vitro.
[Nature Biomedical Engineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists detected an inter-chromosomal insertional duplication in a female proband disrupting a topologically associating domain and causing an ultra-rare progressive form of heterotopic ossification.
[Nature Communications] |
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| By inheriting the advantages of various active proteins contained in cell-free fat extract, it could induce the overall repair of endometrial microenvironment for intrauterine adhesion.
[Small] |
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| Researchers discovered small-molecule drugs that can modulate the tumor microenvironment to enhance immune checkpoint inhibitors treatment efficacy in non–small cell lung cancer in vitro and in vivo.
[Science Advances] |
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| The effects of IL-1β blockade induced by the monoclonal antibodies canakinumab and gevokizumab were evaluated alone or in combination with docetaxel, anti-PD-1, anti-VEGFα and anti-TGFβ treatment in syngeneic and humanized mouse models of cancers of different origin.
[Cancer Immunology Research] |
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| A gelatin methacryloyl (GelMA)-based hydrogel was designed for in vitro and in vivo PDAC experiments.The GelMA-based in vitro 3D culture method could effectively form a gradient and stable ECM stiffness.
[Bioengineering & Translational Medicine] |
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| Scientists utilized in vitro systems, a mouse model, specimens from patients with breast cancer, and RNA expression profiles from The Cancer Genome Atlas Program to investigate the molecular mechanism by which matrix stiffening promotes tumor cell intravasation.
[Cell Reports] |
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| Investigators unveiled a migration phenotype driven by cell-matrix polarity. Cancer (but not normal) cells with stiff base matrix generated stable protrusions, faster migration, and greater collagen deformation because of “depth mechanosensing” through the top collagen layer.
[Cell Reports] |
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| Researchers investigated the therapeutic potential of vitamin D in OA Wistar rats induced by anterior cruciate ligament transection combined with medial meniscectomy. In ACLT + MMx-induced OA rats, pain severity, cartilage destruction, inflammatory cytokines, and MMPs were all measured.
[Heliyon] |
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| In their model, scientists found decreased methylenetetrahydrofolate reductase activity disrupts the regulation of the ECM-specific proteinase matrix metalloproteinase 2 (MMP-2), leading to high levels of MMP-2 and elevated MMP-2-mediated cleavage of the proteoglycan decorin.
[Heliyon] |
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| The authors investigated the effects of A1 overexpression on different populations of catecholaminergic neurons in the central and the peripheral nervous systems.
[Brain Structure & Function] |
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| Investigators ummarize the evidence that not only multiple cancer cell types, but also cells constituting the tumor microenvironment ‘speak the Wnt language’.
[Trends In Molecular Medicine] |
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| The authors review the mechanism of angiogenesis, some important bioactive molecules, and natural and synthetic hydrogels currently being applied for bioactive molecule delivery to treatiIschemic heart disease.
[iScience] |
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| The Society For Biomaterials, a multidisciplinary society of professionals who are dedicated to promoting advancements in all aspects of biomaterials science, education, and professional standards to enhance human health and quality of life, recently announced its slate of 2023 award recipients.
[Society for Biomaterials] |
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| May 7 – 10, 2023
Vancouver, British Columbia, Canada |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | Université de Lausanne – Lausanne, Switzerland |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | Novartis – Cambridge, Massachusetts, United States |
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| | National Institutes of Health – Research Triangle Park, North Carolina, United States |
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Cancer Stem Cell News
Cell Therapy News
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Extracellular Matrix News
Hematopoiesis News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
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Neural Cell News
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