 | | Vol. 14.21 – 20 April, 2023 |
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| Investigators reported that, similar to interphase, mitotic cells could employ integrins to initiate adhesion to the ECM in a kindlin- and talin-dependent manner.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A tendon stem/progenitor cells (TSPCs) delivery system was developed by encapsulating TSPCs within a DNA hydrogel as the DNA hydrogel offered an excellent artificial ECM microenvironment by providing nutrition for proliferation and protection against shear forces.
[Small] |
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| The authors described the design and synthesis of DNA hydrogels, gels composed of DNA that swelled in water, their interactions in vitro with the osteogenic cell lines MC3T3-E1 and mouse calvarial osteoblast, and their promotion of new bone formation in rat calvarial wounds.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Using biochemical, imaging, and multi-omics analyses, researchers found that 11 days of wheel running in male mice causes profound iWAT remodeling including decreased extracellular matrix (ECM) deposition and increased vascularization and innervation.
[Cell Reports] |
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| Investigators found that, compared to standard 2D suspension cultures, 3D collagen as tissue-like environment altered immature dendritic cells properties and their response to HIV-1 infection.
[EMBO Reports] |
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| Alongside the evaluation of cytocompatibility through in vitro cell viability assay, the wound healing efficacy was also determined in full-thickness skin wounds in a rat model for 15 days.
[International Journal of Biological Macromolecules] |
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| The authors reported on a model that has reasonable associated costs, could be handled in a regularly equipped cell lab, and was compatible with ex vivo functional assays including drug sensitivity screens.
[Cell Death Discovery] |
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| Culturing single endothelial cells on microgrooved substrates that constitute an idealized mimic of anisotropic basement membrane topography elicited a strong, groove depth-dependent contact guidance response.
[Advanced Materials Interfaces] |
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| Scientists identified and localized age‑associated ECM differences in human lung using comprehensive transcriptomic, proteomic, and immunohistochemical analyses.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| In a prospective acute myocardial infarction cohort in New Zealand, investigators measured plasma proteins and lipids 30 days after hospital discharge and inferred a unified partial correlation network with echocardiographic variables and established clinical biomarkers.
[Frontiers In Cardiovascular Medicine] |
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| The authors demonstrated that the physicochemical properties of the designed hybrids were similar to those of the original RADA16-I. The materials behaved as expected, leaving the active motif free when treated with elastase.
[Scientific Reports] |
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| Researchers developed ECM substitution to remodel the mechanical properties of diabetic cutaneous wounds and thus accelerate diabetic wound healing.
[Scientific Reports] |
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| The ECM was tightly regulated and dynamically remodeled; this is an important factor for adipose tissue (AT) expansion and can result in modifications to the physical shape and biological function of AT.
[Trends In Cell Biology] |
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| The authors describe the various origin and heterogeneous activation mechanisms of cancer-associated fibroblasts (CAFs), and biological heterogeneity of CAFs in head and neck squamous cell carcinoma is also included.
[Cell Death Discovery] |
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| Scientists cover current strategies targeting myeloid suppressor cells in the tumor microenvironment to enhance anti-tumoral immunity, including strategies that target chemokine receptors to deplete selected immune suppressive myeloid cells and relieve the inhibition imposed on the effector arms of adaptive immunity.
[Frontiers In Oncology] |
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| Dr. Edna Cukierman has been appointed chair-elect of the American Association for Cancer Research’s (AACR) Tumor Microenvironment Working Group at the AACR Annual Meeting 2023, which is being held April 14-19 at the Orange County Convention Center in Orlando, Florida.
[Fox Chase Cancer Center] |
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| May 28 – 31, 2023
Killarney, Ireland |
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| | University of Melbourne – Melbourne, Australia |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | Universit̩ de Lausanne РLausanne, Switzerland |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | Novartis – Cambridge, Massachusetts, United States |
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