Extracellular Matrix News Volume 14.22 | Apr 27 2023

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    2023-04-27 | ECM 14.16


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.22 – 27 April, 2023
    TOP STORY

    Microfluidic Templated Stem Cell Spheroids Microneedles for Diabetic Wound Treatment

    Scientists presented a novel stem cell spheroid-loaded microneedle patch using microfluidic templating technology. By leveraging the precise fluid manipulation capabilities of the microfluidic template, stem cell spheroids with uniform size can be generated in situ.
    [Advanced Materials]

    Abstract
    Request your free copy of the 'Bone Marrow Niches and HSC Fates' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Trehalose-Guanosine Glycopolymer Hydrogels Direct Adaptive Glia Responses in CNS Injury

    Gglycopolymer-based supramolecular hydrogels were synthesized to direct adaptive glia repair after central vervous system (CNS) injury.
    [Advanced Materials]

    Abstract

    Trimanganese Tetroxide Nanozyme protects Cartilage against Degeneration by Reducing Oxidative Stress in Osteoarthritis

    In vitro, Mn3O4 nanozymes were confirmed to reprogram both the imbalance of metabolism in chondrocytes and the uncontrolled inflammatory response stimulated by hydrogen peroxide.
    [Advanced Science]

    Full Article

    In Situ Nitric Oxide Gas Nanogenerator Reprograms Glioma Immunosuppressive Microenvironment

    Investigators designed hybrid drug-loaded nanoliposomes by co-loading the chemotherapeutic drug temozolomide and nitric oxide prodrug JS-K with sphingosine-1-phosphate molecules on the surface.
    [Advanced Science]

    Full Article

    In Situ Tumor Vaccine for Lymph Nodes Delivery and Cancer Therapy Based on Small Size Nanoadjuvant

    An in situ nanovaccine strategy targeting lymph nodes (LNs) to induce powerful antitumor immune responses by converting the primary tumor into whole-cell antigens and then delivering these antigens and nanoadjuvants simultaneously to LNs was proposed.
    [Small]

    Abstract

    The Synovial Environment Steers Cartilage Deterioration and Regeneration

    To investigate why lesions within an osteoarthritis (OA) environment fail to heal, a heterogeneous cell population was isolated from the synovial fluid of OA patients.
    [Science Advances]

    Full ArticlePress Release

    Extracellular Matrix Assembly Stress Initiates Drosophila Central Nervous System Morphogenesis

    Investigators examined the morphogenetic function of an ECM before reaching homeostatic equilibrium by analyzing de novo ECM assembly during Drosophila ventral nerve cord condensation.
    [Developmental Cell]

    AbstractGraphical Abstract

    Proteomic
    Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases

    Scientists described a strategy to develop phage-display libraries of nanobodies against ECM proteins expressed in human metastases, using as immunogens entire ECM-enriched preparations from triple-negative breast cancer and colorectal carcinoma metastases to different organs as immunogens.
    [Cancer Research]

    Abstract

    Proteomic
    Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases

    Researchers described a strategy to develop phage-display libraries of nanobodies against ECM proteins expressed in human metastases, using as immunogens entire ECM-enriched preparations from triple-negative breast cancer and colorectal carcinoma metastases to different organs as immunogens.
    [Cancer Research]

    Abstract

    The Biophysical Property of the Limbal Niche Maintains Stemness through YAP

    The authors focused on how the corneal epithelial stem cell (SC) model in which the SC niche, known as the limbus, was spatially segregated from the differentiation compartment.
    [Cell Death & Differentiation]

    Full Article

    PRDM16 Deficiency in Vascular Smooth Muscle Cells Aggravates Abdominal Aortic Aneurysm

    Investigators found that vascular smooth muscle cells-specific Prdm16 knockout mice already showed extensive changes in the expression of genes associated with ECM remodeling and inflammation in the abdominal aorta under normal housing conditions without any pathological stimuli.
    [JCI Insight]

    AbstractGraphical Abstract
    Explore the Science Events Calendar to discover conferences, podcasts, webinars, and more!
    REVIEWS

    Hydrogels and Bioprinting in Bone Tissue Engineering: Creating Artificial Stem-Cell Niches for In Vitro Models

    The authors highlight challenges in recapitulating the biological complexity seen in bone and how synergistic application of dynamic hydrogels and innovative bioprinting pipelines could address these challenges to achieve bone models.
    [Advanced Materials]

    Abstract

    Fueling the Tumor Microenvironment with Cancer-Associated Adipocytes

    Despite their abundance throughout the body, adipocytes are often ignored for their contributions within the tumor microenvironment (TME). However, their role in fueling cancer is becoming increasingly apparent as interest in the TME has seen remarkable advances in recent years.
    [Cancer Research]

    Abstract

    Skin Aging from the Perspective of Dermal Fibroblasts: The Interplay between the Adaptation to the Extracellular Matrix Microenvironment and Cell Autonomous Processes

    Scientists review how dermal aging involves a feed‐forward process that reinforces the aged dermal fibroblast phenotype and promotes age‐related dermal ECM deterioration, and discuss the expression of the aged dermal fibroblast phenotype.
    [Journal Of Cell Communication And Signaling]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Mount Sinai Launches Institute for Regenerative Medicine

    The Icahn School of Medicine at Mount Sinai announced the creation of the Institute for Regenerative Medicine to foster innovative research into new pathways to cure a host of diseases from leukemia to Alzheimer’s disease, breast cancer, and airway diseases.
    [Icahn School of Medicine at Mount Sinai]]

    Press Release
    FEATURED EVENT

    Hypoxia: From Basic Mechanisms to Emerging Therapies

    May 28 – 31, 2023
    Killarney, Ireland

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer Biology

    Wake Forest University – Winston Salem, North Carolina, United States

    PhD Project – Mechano-Genetic Patterns

    IBDM – Marseille, France

    Postdoctoral Fellow – Tumor Biology

    University of Gothenburg – Gothenburg, Sweden

    Research Fellow – Translational Physiology

    University of Melbourne – Melbourne, Australia

    PhD Positions – Macrograph Landscape in AML

    University Medical Center Groningen – Groningen, Netherlands

    > See All Jobs

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