Extracellular Matrix News Volume 14.24 | May 11 2023

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    2023-05-11 | ECM 14.24


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.24 – 11 May, 2023
    TOP STORY

    A First-in-Human Study of the Fibroblast Activation Protein–Targeted, 4–1BB Agonist RO7122290 in Patients with Advanced Solid Tumors

    This first-in-human study evaluated RO7122290, a bispecific fusion protein carrying a split trimeric 4-1BB ligand and a fibroblast activation protein α (FAP) binding site that costimulates T cells for improved tumor cell killing in FAP-expressing tumors.
    [Science Translational Medicine]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    Spatial Transcriptomic Analysis of Sonic Hedgehog Medulloblastoma Identifies That the Loss of Heterogeneity and Promotion of Differentiation Underlies the Response to CDK4/6 Inhibition

    Investigators used spatially resolved transcriptomics to define the cellular diversity within a sonic hedgehog patient-derived model of medulloblastoma and showed that cells specific to a transcriptional state or spatial location are pivotal for CDK4/6 inhibitor, Palbociclib, treatment response.
    [Genome Medicine]

    Full Article

    Convergence of Scaffold-Guided Bone Regeneration Principles and Microvascular Tissue Transfer Surgery

    Biomechanical, radiological, histological, and immunohistochemical analysis confirmed functional bone regeneration comparable to a clinical gold standard control and was superior to a scaffold control group.
    [Science Advances]

    Full Article

    Antisenescence Therapy Improves Function in a Human Model of Cardiac Fibrosis-on-a-Chip

    Investigators previously developed a model of cardiac fibrosis via TGF-β treatment of engineered microtissues using heart-on-a-chip technology which incorporates human induced pluripotent stem cell-derived cardiomyocytes and cardiac fibroblasts.
    [ACS Materials Au]

    Full ArticleGraphical Abstract

    Anti-Aging Biomaterial Sturgeon Chondroitin Sulfate Upregulating Anti-oxidant and SIRT-1/C-fos Gene Expression to Reprogram Stem Cell Senescence and Prolong Longevity

    Chondroitin sulfate-derived biomaterial from sturgeon is extracted to investigate its antiaging effect in senescence-accelerated mouse prone-8 mice and elucidate the underlying mechanism of its action.
    [Biomaterials Science]

    AbstractGraphical Abstract

    A Spatiotemporal Release Hydrogel Based on an M1-to-M2 Immunoenvironment for Wound Management

    The authors proposed a novel controllable strategy to construct a spatiotemporal dynamical immune-microenvironment for the treatment of cutaneous wounds.
    [Journal Of Materials Chemistry B]

    Abstract

    Peptide-Triggered Self-Assembly of Collagen Mimetic Peptides into Nanospheres by Electrostatic Interaction and π–π Stacking

    Researchers accidentally discovered that FAM-modified positively-charged triple helical peptide FAM-PRG was highly soluble, while the addition of a single-stranded negatively-charged peptide EOG-10 efficiently drove its self-assembly into well-ordered spherical nanomaterials.
    [Journal Of Materials Chemistry B]

    Abstract

    Tissue-Like Cultured Fish Fillets through a Synthetic Food Pipeline

    Scientists developed tissue-like cultured fish fillets by assembly of large yellow croaker muscle fibers and adipocytes with 3D-printed gel.
    [NPJ Science Of Food]

    Full Article

    Kinesin Family Member 23 Knockdown Inhibits Cell Proliferation and Epithelial-Mesenchymal Transition in Esophageal Carcinoma by Inactivating the Wnt/β-Catenin Pathway

    Gene set enrichment analysis was performed to investigate the pathways associated with the regulatory mechanisms of KIF23 in esophageal carcinoma.
    [Functional & Integrative Genomics]

    Abstract
    An ISSCR 2021 Innovation Showcase Webinar: Facilitating hPSC Workflows with CloneR ™2, presented by Dr. Adam Hirst. Click to Watch Now.
    REVIEWS

    Matrix Metalloproteinases in Arthritis: Towards Precision Medicine

    Insights into beneficial and detrimental effects of matrix metalloproteinases (MMPs) on joint tissue inflammation are also necessary to plan and execute (pre)clinical studies for better therapy and precision medicine with MMP inhibitors.
    [Nature Reviews Rheumatology]

    Abstract

    The Chemistry and Biology of Collagen Hybridization

    Scientists describe the concept and development of collagen hybridization, summarize the decades of chemical investigations on rules underlying the collagen triple-helix folding, and discuss the growing biomedical evidence on collagen denaturation as a previously overlooked ECM signature.
    [Journal Of The American Chemical Society]

    Abstract
    INDUSTRY AND POLICY NEWS

    Engineered Kidney And Liver Tissues to Fly On Ax-2

    Researchers from the Wake Forest Institute for Regenerative Medicine are partnering with the RegenMed Development Organization to send bioengineered liver and kidney constructs to space to explore ways to help reduce the number of people waiting for vital organs.
    [ISS National Laboratory]

    Full Article

    Lineage Receives Grant From California Institute for Regenerative Medicine (CIRM)

    Lineage Cell Therapeutics, Inc. announced that the company has received a grant from the CIRM, to support the 1st Annual Spinal Cord Injury Investor Symposium, a newly created forum to discuss the recent innovation, advancements, and challenges in the treatment of spinal cord injury.
    [Lineage Cell Therapeutics, Inc. (BusinessWire, Inc.)]

    Press Release
    FEATURED EVENT

    Life at the Periphery: Mechanobiology of the Cell Surface

    June 12 – 15, 2023
    EMBL Heidelberg and Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Cellular Highways of the ECM

    National University of Singapore – Singapore, Singapore

    PhD Student – Early Detection of Liver Cancer

    Helmholtz Association of German Research Centres – Heidelberg, Germany

    Postdoctoral Position – Cellular Topography Sensing

    Institut Pasteur – Paris, France

    Postdoctoral Fellow – Cancer Biology

    Wake Forest University – Winston Salem, North Carolina, United States

    PhD Project – Mechano-Genetic Patterns

    IBDM – Marseille, France

    > See All Jobs

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