Matrix Metalloproteinase-9 Inhibition Reduces Inflammation and Improves Motility in Murine Models of Post-Operative Ileus Researchers evaluated the role of matrix metalloproteinase-9 (MMP-9) in post-operative ileus (POI) and investigated whether disruption of MMP-9 or administration of an inhibitor of MMP-9 activity reduced cellular inflammation and bowel dysmotility in rat and mouse models of POI. [Gastroenterology] The Effect of Composition of Calcium Phosphate Composite Scaffolds on the Formation of Tooth Tissue from Human Dental Pulp Stem Cells In the present study, researchers tested biocompatibility of four different types of 3-D scaffolds for tooth-tissue regeneration, including a pure poly(lactide-co-glycolide) scaffold and three types of calcium phosphate contained composites scaffolds. [Biomaterials] MMP-9 from Sublethally Irradiated Tumor Promotes Lewis Lung Carcinoma Cell Invasiveness and Pulmonary Metastasis Researchers sought to investigate the role of matrix metalloproteinase-9 (MMP-9) from sublethally irradiated tumor in accelerated pulmonary metastasis of Lewis lung carcinoma and the corresponding anti-metastasis strategies in C57BL/6 mice. [Oncogene] The Transcriptional Regulator Megakaryoblastic Leukemia-1 Mediates Serum Response Factor-Independent Activation of Tenascin-C Transcription by Mechanical Stress Researchers demonstrate that overexpression of megakaryoblastic leukemia-1 strongly induces tenascin-C expression in mouse NIH3T3 fibroblasts and normal HC11 and transformed 4T1 mammary epithelial cells. [FASEB J] Control of Megakaryocyte Expansion and Bone Marrow Fibrosis by Lysyl Oxidase Researchers examined the expression and functions of lysyl oxidase in megakaryocytes, the platelet precursors. [J Biol Chem] MMP-2/MMP-9 Plasma Level and Brain Expression in Cerebral Amyloid Angiopathy-Associated Hemorrhagic Stroke In this study, researchers determined the levels of matrix metalloproteinase-2 (MMP-2) and MMP-9 in plasma and their brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke. [Brain Pathol] TGF-β3 Stimulates Cartilage Matrix Elaboration by Human Marrow-Derived Stromal Cells Encapsulated in Photocrosslinked Carboxymethylcellulose Hydrogels: Potential for Nucleus Pulposus Replacement The results demonstrate that human marrow-derived stromal cells encapsulated in photocrosslinked carboxymethylcellulose hydrogels supplemented with transforming growth factor-β3 (TGF-β3) are capable of elaborating functional extracellular matrix consistent with the nucleus pulposus phenotype. [Tissue Eng Part A] The Effect of Mesenchymal Stromal Cell-Hyaluronic Acid Hydrogel Constructs on Immunophenotype of Macrophages Researchers investigated the effect of mesenchymal stromal cells on immunophenotype of macrophages in the presence of an hyaluronic acid–hydrogel scaffold using a unique 3D coculture system. [Tissue Eng Part A] The Type II Collagen N-Propeptide, PIIBNP, Inhibits Cell Survival and Bone Resorption of Osteoclasts via Integrin-Mediated Signaling Researchers undertook in vitro and in vivo experiments to evaluate both osteoblast and osteoclast functions in the presence of recombinant type IIB procollagen NH2-propeptide (PIIBNP). [Bone] Dual Targeting of EGFR and Focal Adhesion Kinase in 3D Grown HNSCC Cell Cultures To examine effects of dual epidermal growth factor (EGFR)/focal adhesion kinase (FAK) inhibition on cellular radiosensitivity of head and neck squamous cell carcinoma (HNSCC) cells in a more physiological environment, researchers employed a previously established laminin-rich extracellular matrix based three-dimensional cell culture model. [Radiother Oncol] Elevated MMP-7 Levels in Patients with Systemic Sclerosis: Correlation with Pulmonary Involvement Researchers investigated whether serum matrix metalloproteinase-7 (MMP-7) levels reflect the activity of the fibrotic reaction in systemic sclerosis. [Exp Dermatol] |