Extracellular Matrix News Volume 2.28 | Jul 21 2011

Faulty Initiation of Proteoglycan Synthesis Causes Cardiac and Joint Defects
Patient fibroblasts demonstrated decreased levels of dermatan sulfate, chondroitin sulfate, and heparan sulfate proteoglycans, indicating that the defect in linker synthesis affected all three lines of O-glycanated proteoglycans. [Am J Hum Genet]

The Promotion of Stemness and Pluripotency Following Feeder-Free Culture of Embryonic Stem Cells on Collagen-Grafted 3-Dimensional Nanofibrous Scaffold
In this study, researchers analyzed the maintenance of stemness and pluripotency of the mouse embryonic stem cell following feeder-free culture on collagen-grafted polyethersulfone electrospun nanofibrous scaffold. [Biomaterials]

A Novel Functional Role of Collagen Glycosylation: Interaction with the Endocytic Receptor uPARAP/Endo180
In this study, researchers have investigated a possible role of the single active lectin domain of uPARAP/Endo180 in the interaction with collagens. [J Biol Chem]

Glycosaminoglycans and Glucose Prevent Apoptosis in 4-Methylumbelliferone Treated Human Aortic Smooth Muscle Cells
Researchers used the hyaluronan (HA) synthesis inhibitor 4-methylumbelliferone to reduce HA production in human aortic smooth muscle cells and found a significant increase of apoptotic cells. [J Biol Chem]

Type IX Collagen Interacts with Fibronectin Providing an Important Molecular Bridge in Articular Cartilage
Researchers suggest that the novel interaction between the N-terminal, globular non-collagenous domain of type IX collagen and fibronectin may represent an in vivo interaction in cartilage that could contribute to the matrix integrity of the tissue. [J Biol Chem]

Distinct Spatio-Temporal Extracellular Matrix Accumulation within Demyelinated Spinal Cord Lesions in Theiler’s Murine Encephalomyelitis
Theiler’s murine encephalomyelitis as a model of multiple sclerosis served to evaluate the spatio-temporal course of extracellular matrix alterations in demyelinating conditions. [Brain Pathol]

The Maturity of Tissue Engineered Cartilage In Vitro Affects the Reparability for Osteochondral Defect
Researchers used a rabbit model to evaluate the extent to which the maturity of engineered cartilage influenced the remodeling and integration of implanted extracellular matrix scaffolds containing allogenous chondrocytes. [Tissue Eng Part A]

Ectopic Chondro-Ossification and Erroneous Extracellular Matrix Deposition in a Tendon Window Injury Model
Researchers investigated the presence of chondrocyte phenotype, ossification, and the changes in the expression of major collagens and proteoglycans in the window wound in a rat patellar tendon window injury model using histology, von Kossa staining and immunohistochemistry of Sox 9, major collagens, and proteoglycans. [J Orthop Res]

SpinalCyte, LLC Receives U.S. Patent for Spinal Disc Tissue Engineering
SpinalCyte, LLC announced the U.S. Patent Office issued Patent #7,850,983 “Methods and Compositions for Repair of Cartilage Using An In Vivo Bioreactor” to regrow the spinal disc, using human dermal fibroblasts. [Business Wire]

KCI Announces Agreement to Be Acquired by Consortium
Kinetic Concepts, Inc. (KCI) announced that it has entered into a definitive merger agreement under which a consortium comprised of funds advised by Apax Partners, together with controlled affiliates of Canada Pension Plan Investment Board and the Public Sector Pension Investment Board, will acquire KCI for $68.50 per share in cash in a transaction valued at $6.3 billion (including KCI’s outstanding debt). [Kinetic Concepts,Inc. Press Release]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Extracellular Matrix Protein Study (Università degli Studi di Genova)

Research Associate in Synthetic Biology (Institute of Systems and Synthetic Biology)

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