Lysyl Oxidase-Like Protein-2 Regulates Sprouting Angiogenesis and Type IV Collagen Assembly in the Endothelial Basement Membrane Researchers performed a proteomic analysis of extracellular matrix from endothelial cells maintained in hypoxia, a major stimulator of angiogenesis. [Blood] Hyperphosphorylation of Mouse Cardiac Titin Contributes to Transverse Aortic Constriction-Induced Diastolic Dysfunction Transverse aortic constriction-induced heart failure results in increased extracellular matrix-based and titin-based passive stiffness. [Circ Res] The Inhibition of Infection by Wound Pathogens on Scaffold in Tissue-Forming Process Using N-Acetyl Cysteine This in vitro study evaluated whether N-acetyl cysteine prevented bacterial infection of gingival fibroblasts and osteoblasts on a scaffold. [Biomaterials] Low Carotid Calcium Score Is Associated With Higher Levels of Glycosaminoglycans, Tumor Necrosis Factor-Alpha, and Parathyroid Hormone in Human Carotid Plaques This study assesses the relation between carotid calcium score by computed tomography and plaque composition, namely extracellular matrix, inflammatory mediators, and calcium metabolites. [Stroke] Immobilizing Reporters for Molecular Imaging of the Extracellular Microenvironment in Living Animals Researchers report here an immobilization strategy using a collagen binding protein to deliver and confine synthetic reporters to the extracellular microenvironment in vivo for non-invasively imaging the activity of targets in the microenvironment. [ACS Chem Biol] Using Self-Assembled Monolayers To Understand α8β1-Mediated Cell Adhesion to RGD and FEI Motifs in Nephronectin This paper describes the use of self-assembled monolayers to study the adhesion of α8β1-presenting cells to the RGD and DLFEIFEIER ligands in nephronectin and found that both ligands can independently mediate cell adhesion through nonoverlapping binding sites on the integrin. [ACS Chem Biol] Peculiarities of the Extracellular Matrix in the Interstitium of the Renal Stem/Progenitor Cell Niche The applied technique appears to be a suitable method to illuminate the interstitium in stem/progenitor cell niches of specialized tissues, the microenvironment of tumors and extension of degeneration. [Histochem Cell Biol] Pulmonary Fibroblasts Mobilize the Membrane-Tethered Matrix Metalloprotease, MT1-MMP, to Destructively Remodel and Invade Interstitial Type I Collagen Barriers Herein, membrane type-1 matrix metalloprotease (MT1-MMP) is identified as the dominant, and direct-acting, protease responsible for the type I collagenolytic activity mediated by both mouse and human pulmonary fibroblasts. [Am J Physiol Lung Cell Mol Physiol] Extracellular Matrix (ECM) Molecules Implicated in Hypertrophic and Keloid Scarring To summarize what is known about the expression and composition of ECM molecules in abnormal scarring, an extensive search of the literature was conducted, focusing on keywords connected to skin scarring, hypertrophic scars and keloid disease. The transcription and translation of collagen I and III, fibronectin, laminin, periostin and tenascin are all increased in raised dermal scar tissue. [J Eur Acad Dermatol Venereol] ECM-Based Triple Layered Scaffolds for Vascular Tissue Engineering The present study focused on the development of three layered small-diameter (<6 mm) extracellular matrix (ECM)-based vessels. These were engineered artificially through the freeze-drying technique. [Int J Mol Med] |