Extracellular Matrix News Volume 2.35 | Sep 8 2011

Cdc42 Regulates Extracellular Matrix Remodeling in Three Dimensions
Here researchers employ three-dimensional culture systems for conditional gene targeted primary mouse embryonic fibroblasts that better simulate the reciprocal and adaptive interactions between cells and surrounding matrix, to define the role of Cdc42 signaling pathways in extracellular matrix organization. [J Biol Chem] Abstract

miR-146a–Mediated Extracellular Matrix Protein Production in Chronic Diabetes Complications
Studies showed a novel, glucose-induced molecular mechanism in which miR-146a participates in the transcriptional circuitry regulating extracellular matrix protein production in diabetes. [Diabetes] Abstract

Perfluorodecalin-Enriched Fibrin Matrix for Human Islet Culture
This study aimed to create a matrix for culturing islets, using fibrin as scaffold and perfluorodecalin as oxygen diffusion enhancing medium. [Biomaterials] Abstract

Selective Adhesion and Growth of Vascular Endothelial Cells on Bioactive Peptide Nanofiber Functionalized Stainless Steel Surface
In this study, researchers developed self-assembled peptide nanofibers that mimic the native endothelium extracellular matrix and that are securely immobilized on stainless steel surface through mussel-inspired adhesion mechanism. [Biomaterials] Abstract

Human Cardiosphere-Seeded Gelatin and Collagen Scaffolds as Cardiogenic Engineered Bioconstructs
In this study researchers compared the structural and biological features of collagen or gelatin-based bioconstructs, seeded with human adult cardiac progenitor cells in the form of cardiospheres. [Biomaterials] Abstract

The Critical Role of the Epidermal Growth Factor Receptor in Endochondral Ossification
Researchers conclude that epidermal growth factor receptor signaling plays an essential role in the remodeling of growth plate cartilage extracellular matrix into bone during endochondral ossification. [J Bone Miner Res] Abstract

Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds
This work demonstrates the ability to use decellularized brain extracellular matrix for cell culture and tissue engineering applications. [Tissue Eng Part A] Abstract

Facile Surface Functionalization with Glycosaminoglycans by Direct Coating with Mussel Adhesive Protein
In the present work, researchers suggest a new, simple surface functionalization platform based on the charge interactions between the positively charged mussel adhesive protein linker and negatively charged extracellular matrix molecules, such as glycosaminoglycans. [Tissue Eng Part C Methods] Abstract

PED/PEA-15 Interacts with the 67 kDa Laminin Receptor and Regulates Cell Adhesion, Migration, Proliferation and Apoptosis
PED/PEA-15 ability to induce cell responses to extracellular matrix-derived signals through interaction with 67LR may be of crucial importance for tumor cell survival in a poor microenvironment, thus favoring the metastatic spread and colonization. [J Cell Mol Med] Abstract

IFNβ Impairs Extracellular Matrix Formation Leading to Inhibition of Mineralization by Effects in the Early Stage of Human Osteoblast Differentiation
Researchers demonstrated that IFNβ has severe inhibitory effects on mineralization of osteoblast-derived extracellular matrix. [J Cell Physiol] Abstract

Interleukin-17F Affects Cartilage Matrix Turnover by Increasing the Expression of Collagenases and Stromelysin-1 and by Decreasing the Expression of their Inhibitors and Extracellular Matrix Components in Chondrocytes
In the present study, researchers examined the effect of IL-17F on the degradation and synthesis of the extracellular matrix in cartilage using human articular chondrocytes. [Cytokine] Abstract

 

Kane Biotech Files New Patent on Bone Tissue Regeneration Invention
Kane Biotech Inc. announced the invention and patenting of a new bone tissue regenerating fusion peptide based on the Company’s competence stimulating peptide oral care technology. [Kane Biotech Inc.] Press Release

Allied Healthcare’s Celxcel Granted Tissue Engineering Patent
Allied Healthcare Group Limited announced that IP Australia has granted its Celxcel business a patent for its proprietary ADAPT Tissue Engineering Process titled “An Implantable Biomaterial and a Method of Producing Same”. [Allied Healthcare Group Limited] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Gordon Research Seminar: Signal Transduction by Engineered Extracellular Matrices
July 7-8, 2012
Biddeford, United States

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Post-Doctoral Position at ECM Biology Lab (University of Pennsylvania)

Post-Doctoral Position: Extracellular Matrix and Tendon Development (Institut de Génomique Fonctionnelle de Lyon)

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