| PUBLICATIONS (Ranked by Impact Factor of the Journal) | Self-Assembly of Collagen-Mimetic Peptide Amphiphiles into Biofunctional Nanofiber In this work, a novel collagen-mimetic peptide amphiphile was prepared by conjugating a single hydrophobic tail with a collagen-mimetic peptide, supplemented with bioactive glycine-phenylalanine-hydroxyproline-glycine-glutamate-arginine. [ACS Nano] Abstract A Cell-Instructive Hydrogel to Regulate Malignancy of 3D Tumor Spheroids with Matrix Rigidity This study reports an advanced strategy to assemble 3D liver tumor spheroids with controlled intercellular organization, phenotypes, and angiogenic activities using hydrogels with controlled stiffness and minimal differences in molecular diffusivity. [Biomaterials] Abstract Selective Inhibition of Matrix Metalloproteinase-13 Increases Collagen Content of Established Mouse Atheromas This study, of considerable clinical relevance, furnishes new mechanistic insight into regulation of the plaque’s extracellular matrix and validates molecular imaging for studying plaque biology. [Arterioscler Thromb Vasc Biol] Abstract Collagen VI: Conformation of A-Domain Arrays and Microfibril Architecture Collagen VI microfibrils are typically formed from a heterotrimer of the a1, a2 and a3 chains. The a3 chain is distinct as it contains an extended N-terminus with up to ten consecutive von Willebrand factor type A-domains. Here researchers use solution small angle X-ray scattering and single particle analysis EM to determine the nanostructure of nine of these contiguous A-domains. [J Biol Chem] Abstract In Vitro Cartilage Tissue Engineering Using Adipose-Derived Extracellular Matrix Scaffolds Seeded with Adipose-Derived Stem Cells Here, researchers explored cartilage tissue engineering using extracellular matrix scaffolds seeded with stem cells. [Tissue Eng Part A] Abstract Evaluation of a Thin and Mechanically Stable Collagen Cell Carrier In the present study, researchers evaluated the mechanical and the cell biological properties of a novel, thin, and planar collagen scaffold. [Tissue Eng Part C Methods] Abstract A Novel Method for the Fabrication of Fibrin Based Electrospun Nanofibrous Scaffold for Tissue Engineering Applications In this study, fibrin, which is superior to fibrinogen both in structural and functional properties, has for the first time been electrospun successfully into uniform nano fibers resembling the extracellular matrix. [Tissue Eng Part C Methods] Abstract Diffusion of MMPs on the Surface of Collagen Fibrils: The Mobile Cell Surface – Collagen Substratum Interface Researchers propose that the collagenolytic complex (MT1-MMP)2/TIMP-2/MMP-2 represents a Mobile Cell Surface – Collagen Substratum Interface. The biological implications of MT1-MMP acting as a molecular ratchet tethered to the cell surface in complex with MMP-2 suggest a new mechanism for the role of spatially regulated peri-cellular proteolysis in cell-matrix interactions. [PLoS ONE] Abstract ß-Catenin Signaling is Required for TGF-ß1-Induced Extracellular Matrix Production by Airway Smooth Muscle Cells In this study, researchers investigated the activation of ß-catenin signaling and its contribution to extracellular matrix production by airway smooth muscle cells in response to TGF-ß1. [Am J Physiol Lung Cell Mol Physiol] Abstract Quantification of Collagen Organization and Extracellular Matrix Factors within the Healing Ligament Using a combination of advanced histology, molecular biology, and nonlinear optical imaging approaches, the early extracellular matrix events during ligament healing have been better characterized and defined. [Microsc Microanal] Abstract |
| INDUSTRY NEWS | Australia, Singapore Pledge Commitment to Further Scientific Collaboration Singapore’s Agency for Science, Technology and Research and Australia’s National Health and Medical Research Council have signed a Memorandum of Understanding to promote exchange between the two countries in the areas of health and medical research. [Agency for Science, Technology and Research] Press Release ViroPharma and Halozyme Therapeutics Announce Initiation of Phase 2 Evaluation of Subcutaneous Delivery of Cinryze® (C1 Esterase Inhibitor [Human]) with Hyaluronidase (rHuPH20) ViroPharma Incorporated and Halozyme Therapeutics announced that ViroPharma has initiated an open-label, multi-dose Phase 2 study to evaluate the safety, and pharmacokinetics and pharmacodynamics of subcutaneous administration of Cinryze® (C1 esterase inhibitor [human]) in combination with Halozyme’s Enhanze™ technology, a proprietary drug delivery platform using Halozyme’s recombinant human hyaluronidase enzyme (rHuPH20), in subjects with hereditary angioedema. [ViroPharma Incorporated] Press Release HYALGAN® (Sodium Hyaluronate) Commercial Rights Transfer Back to Fidia Farmaceutici S.p.A. Fidia Farmaceutici S.p.A. (Fidia) announced that commercial rights for HYALGAN ® (sodium hyaluronate), an injectable treatment for knee pain caused by osteoarthritis when simple painkillers or exercise and physical therapy are not enough, will be transferred from Sanofi US LLC back to Fidia on September 24, 2011. [MarketWatch] Press Release |
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