| PUBLICATIONS (Ranked by Impact Factor of the Journal) | Epimorphin Promotes Human Hepatocellular Carcinoma Invasion and Metastasis through Activation of Focal Adhesion Kinase/Extracellular Signal-Regulated Kinase/Matrix Metalloproteinase-9 Axis Researchers demonstrate that epimorphin, an extracellular protein, is strongly elevated in activated hepatic stellate cells within tumor stroma. [Hepatology] Abstract Neural Cell Type-Specific Responses to Glycomimetic Functionalized Collagen In this study, researchers have functionalized type I collagen with peptide mimics of two glycans: (1) polysialic acid and (2) an epitope first discovered on human natural killer cells. [Biomaterials] Abstract Glycosaminoglycans from Aged Human Hippocampus Have Altered Capacities to Regulate Trophic Factors Activities but Not Aβ42 Peptide Toxicity Here, researchers studied levels and composition of glycosaminoglycans isolated from adult and aged human hippocampus and investigated if their changes can influence the function of important trophic factors and the Aβ42 peptide toxicity. [Neurobiol Aging] Abstract Simultaneous Analysis of Heparan Sulfate, Chondroitin/Dermatan Sulfates and Hyaluronan Disaccharides by Glycoblotting-Assisted Sample Preparation Followed by Single-Step ZIC-HILIC Chromatography The present work describes a novel analytical technique that enables high throughput cellular/tissue glycosaminoglycomics for all three families of uronic acid-containing glycosaminoglycans, hyaluronan, chondroitin sulfate/dermatan sulfate, and heparan sulfate. [Anal Chem] Abstract Protein and Mineral Composition of Osteogenic Extracellular Matrix Constructs Generated with a Flow Perfusion Bioreactor This study investigated the temporal composition of an osteogenic extracellular matrix construct generated by culturing mesenchymal stem cells in an electrospun biodegradable poly(ε-caprolactone) fiber mesh scaffold within a flow perfusion bioreactor. [Biomacromolecules] Abstract Proteomic Analysis of Col11a1-Associated Protein Complexes Extracellular matrix molecules and cellular proteins that were identified as interacting with the amino terminal domain of collagen alpha 1(XI) directly or indirectly, included proteoglycans, collagens, and matricellular molecules, some of which also play a role in fibrillogenesis, while others are known to function in the maintenance of tissue integrity. [Proteomics] Abstract Enhanced Secretion of Tissue Inhibitor of Metalloproteinases-1 by Human Hypertrophic Scar Keratinocytes Could Contribute to Fibrosis The findings of this study represent an important advance in understanding the role of keratinocytes as a direct potent modulator for matrix degradation and scar tissue remodeling, possibly through inactivation of matrix metalloproteinases (MMPs). [Burns] Abstract |
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