Extracellular Matrix News Volume 2.48 | Dec 8 2011By Justin.choi - May 12, 2022019Extracellular Matrix News 2.48, December 8, 2011 In this issue: Publications | Industry News | Policy News | Events | Jobs TOP STORYThe Involvement of Integrin β1 Signaling in the Migration and Myofibroblastic Differentiation of Skin Fibroblasts on Anisotropic Collagen-Containing Nanofibers In this study, the phenotypic expressions of normal human dermal fibroblasts on collagen-containing nanofibrous matrices with either isotropic or anisotropic fiber organizations were studied by immunostaining, migration assay and molecular analyses. [Biomaterials] Abstract PUBLICATIONS (Ranked by Impact Factor of the Journal)Consequences of Ineffective Decellularization of Biologic Scaffolds on the Host Response The objective of this study was to evaluate the consequences of ineffective decellularization on host response. [Biomaterials] Abstract Dual Regulation of Breast Tubulogenesis Using Extracellular Matrix Composition and Stromal Cells Here, researchers used a three dimensional in vitro culture to study the roles of stromal cells and extracellular matrix components during mammary tubulogenesis. [Tissue Eng Part A] Abstract Feedback Regulation of the α2(1) Collagen Gene via the Mek-Erk Signaling Pathway In this study, a fibroblast-derived extracellular matrix was used to study the feedback regulation of type I collagen synthesis in fibroblasts. [IUBMB Life] Abstract The Effect of Valproic Acid and Oxcarbamazepine on the Distribution of Adhesion Molecules in Embryo Implantation This study was intended to investigate the effect of valproate and oxcarbamazepine on embryo implantation in terms of extracellular matrix protein distribution. [Toxicology] Abstract Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration Using in vitro and ex vivo models of vessel wall stiffness and aging, researchers show that stiffening of extracellular matrix within the intima promotes endothelial cell permeability-a hallmark of atherogenesis. [Sci Transl Med] Abstract SPARC Modulates Expression of Extracellular Matrix Genes in Human Trabecular Meshwork Cells The purpose of this study was to investigate the effects of secreted protein acidic and rich in cysteine (SPARC) on the expression of components of the extracellular matrix in cultured human trabecular meshwork cells. [Acta Ophthalmol] Abstract Cigarette Smoke Extract Induces Select Matrix Metalloproteinase and Integrin Expression in Periodontal Ligament Fibroblasts This study examined the direct effect of smoking on periodontal ligament fibroblasts and their production of various matrix components and remodeling enzymes. [J Periodontol] Abstract Potential of Healing a Transected Anterior Cruciate Ligament with Genetically Modified Extracellular Matrix Bioscaffolds in a Goat Model This study examined the potential advantages of using extracellular matrix bioscaffolds from galactosyl-α(1,3)galactose deficient pigs to heal the transected anterior cruciate ligament. [Knee Surg Sports Traumatol Arthrosc] Abstract INDUSTRY NEWSKarolinska Institute and Mayo Clinic Strengthen Their Cooperation The scope of Karolinska Institute’s cooperation with one of the world’s leading health organizations, Mayo Clinic, is now being extended through a formal contract. [Karolinska Institute] Press Release ViroPharma and Halozyme Therapeutics Announce Positive Data From Initial Phase II Assessment of Subcutaneous Cinryze® (C1 Esterase Inhibitor [human]) with Hyaluronidase ViroPharma Incorporated and Halozyme Therapeutics announced positive data from ViroPharma’s open-label, multiple dose Phase II clinical trial designed to evaluate the safety, pharmacokinetics and pharmacodynamics of subcutaneous administration of Cinryze® in combination with Halozyme’s Enhanze™ technology in subjects with hereditary angioedema. [Halozyme Therapeutics, Inc.] Press Release POLICY NEWSNational Institutes of Health (United States) Food and Drug Administration (United States) Center for Biologics Evaluation and Research (United States) European Medicines Agency (European Union) Medicines and Healthcare Products Regulatory Agency (United Kingdom) Therapeutic Goods Administration (Australia)EVENTSNEW Keystone Symposia on Molecular and Cellular Biology – Fibrosis: Translation of Basic Research to Human Disease and Novel Therapeutics March 30 – April 4, 2012 Big Sky, United States Visit our events page to see a complete list of events in the extracellular matrix community.JOB OPPORTUNITIESResearch and Development Technologist, hPSC Media (STEMCELL Technologies) Scientist – Pluripotent Stem Cells (STEMCELL Technologies) Research Technologist, Manufacturing Sciences (STEMCELL Technologies) Business Analyst – Product Management (STEMSOFT Software) Post-Doctoral/Research Scientist – (Mount Sinai School of Medicine) Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost. 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