Extracellular Matrix News Volume 3.02 | Jan 19 2012

Fer Kinase Regulates Cell Migration through α-Dystroglycan Glycosylation
Researchers’ results indicate that the Fer pathway negatively controls expression of genes required to synthesize laminin-binding glycans, thus impairing basement membrane attachment and increasing tumor cell migration. [Mol Biol Cell] Abstract

Fibronectin Induces Endothelial Cell Migration through β1-Integrin and Src Dependent Phosphorylation of Fibroblast Growth Factor Receptor-1 at Tyrosines 653/654 and 766
Researchers demonstrate how differential phosphorylation profiles of fibroblast growth factor receptor-1 can achieve alternate downstream signals, and more broadly, highlight the diversity of mechanisms by which the extracellular matrix microenvironment regulates cell behavior through transactivation of receptor tyrosine kinases. [J Biol Chem] Abstract

Nanofibrous Collagen Nerve Conduits for Spinal Cord Repair
In this study, the potential application of electrospun collagen nanofibers for spinal cord injury treatment was evaluated in vitro and in vivo. [Tissue Eng Part A] Abstract

Epigenetic Regulation of Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts
Researchers aim was to study the effect of trichostatin A on transforming growth factor-β1-induced myofibroblast differentiation and extracellular matrix accumulation in nasal polyp-derived fibroblasts. [Clin Exp Allergy] Abstract

Growth Factor Regulation of Corneal Keratocyte Mechanical Phenotypes in Three-Dimensional Collagen Matrices
The purpose of this study was to assess how wound healing cytokines and the extracellular matrix environment regulate the keratocyte mechanical phenotype. [Invest Ophthalmol Vis Sci] Abstract

Passive and Active Contributions to Generated Force and Retraction in Heart Valve Tissue Engineering
Within this study, researchers unraveled the passive and active contributions of cells and matrix to generated force and retraction in engineered heart valve tissues. [Biomech Model Mechanobiol] Abstract

The Inhibition of Hyaluronan Degradation Reduced Pro-Inflammatory Cytokines in Mouse Synovial Fibroblasts Subjected to Collagen-Induced Arthritis
Researchers aimed to investigate the effects of inhibiting hyaluronan degradation on synovial fibroblasts obtained from normal DBA/J1 mice and on synovial fibroblasts obtained from mice subjected to collagen induced arthritis, both fibroblast types stimulated with tumor necrosis factor-α. [J Cell Biochem] Abstract

Extracellular Acidosis Accelerates Bone Resorption by Enhancing Osteoclast Survival, Adhesion, and Migration
Researchers’ findings indicate that extracellular acidosis stimulates bone resorption by extending osteoclast survival and facilitating osteoclast adhesion and migration. [Biochem Biophys Res Commun] Abstract

Biomedical Structures Introduces Novel Absorbable BIOFELT^® Scaffold for Breakthrough Surgical Applications
Biomedical Structures, LLC announced its new BIOFELT^® absorbable scaffold for implant devices in orthopedics, cardiology, and general surgery, as well as other in vivo applications. BIOFELT’s unique non-woven structure provides a fibrous matrix platform that enables natural tissue in-growth in surgical applications. [Biomedical Structures, LLC] Press Release

SpineSmith Adds Talented Scientist to Research and Development Team
SpineSmith is pleased to announce the addition of Dr. Matthew Murphy to its team of PhDs. [PR Newswire] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Positions – Tissue-Engineering (Sabanci University)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science)

Recruit Top Talent
Reach more than 11,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Jobs are categorized regionally: United States, Canada, Europe, Asia Pacific

Visit here to post your career opportunities.

Have we missed an important article or publication in Extracellular Matrix News? Click here to submit!

Comments or Suggestions? Email info@connexoncreative.com with your feedback.