Protein-Anchoring Strategy for Delivering Acetylcholinesterase to the Neuromuscular Junction Researchers demonstrate for the first time in vivo that the triple helical collagen Q protein contains a tissue-targeting signal that is sufficient for anchoring itself to the neuromuscular junction. They propose that the protein-anchoring strategy is potentially applicable to a broad spectrum of diseases affecting extracellular matrix molecules. [Mol Ther] Abstract
VANGL2 Regulates Membrane Trafficking of MMP14 to Control Cell Polarity and Migration This study identifies a novel mechanism linking vang-like 2 (VANGL2) with matrix metalloproteinase 14 (MMP14) trafficking and suggests that establishment of planar cell polarity in migrating gastrula cells requires regulated proteolytic degradation/remodeling of extracellular matrix. [J Cell Sci] Abstract
Sulfatases Are Determinants of Alveolar Formation Although glycosaminoglycans (GAGs) are known to regulate growth factor distribution and activity according to their degree of sulfation the role of sulfated GAG in the respiratory system is not well understood. Here, researchers utilized mice lacking sulfatase-modifying factor 1 to study the importance of proteoglycan desulfation in lung development. [Matrix Biol] Abstract
Vomaris Innovations, Inc. Names New CEO Vomaris Innovations, Inc., a leading regenerative medicine company focusing on wound care with bioelectric technology, has named Michael P. Nagel as its new President and Chief Executive Officer. [PR Newswire] Press Release
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