Extracellular Matrix News Volume 4.46 | Nov 21 2013

Mechanoregulation of Valvular Interstitial Cell Phenotype in the Third Dimension
The authors characterized the combined effects of boundary stiffness and transforming growth factor-β1 on cell-generated forces and collagen accumulation. [Biomaterials] Abstract

Proteomic Analysis of the Extracellular Matrix Produced by Mesenchymal Stromal Cells: Implications for Cell Therapy Mechanism
To understand the underlying mechanism(s) by which notch1 intracellular domain (NICD)-transfected mesenchymal stromal cells (MSC)-derived extracellular matrix (ECM) supports neural cell growth and survival, scientists investigated the differences in NICD-transfected MSC- and MSC-derived ECM protein quantity and composition. [PLoS One] Full Article

Factors Involved in Extracellular Matrix Turnover in Human Derived Cardiomyocytes
Researchers determined that hypoxia and increased TNFα activity likely exert cardioprotective actions by activating the cardiac antifibrogenic factors Apelin and VEGF. In contrast, IL1β is a strong promoter of interstitial collagen remodeling that may contribute to ventricular dilation and heart failure in the ischemic myocardium. [Cell Physiol Biochem] Full Article

Adiponectin Mediated APPL1-AMPK Signaling Induces Cell Migration, MMP Activation, and Collagen Remodeling in Cardiac Fibroblasts
The authors first demonstrated temporal relocalization of cellular APPL1 in response to adiponectin in primary cardiac fibroblasts and that siRNA-mediated knockdown of APPL1 attenuated stimulation of AMPK by adiponectin. The cell surface content of MT1-MMP and activation of MMP2 were induced by adiponectin and these responses were dependent on AMPK signaling. [J Cell Biochem] Abstract

Heparinization of a Biomimetic Bone Matrix: Integration of Heparin during Matrix Synthesis versus Adsorptive Post Surface Modification
Researchers evaluated a contemporary concept of scaffolding in bone tissue engineering in order to mimic functions of the extracellular matrix. The investigated approach considered the effect of the glycosaminoglycan heparin on structural and biological properties of a synthetic biomimetic bone graft material consisting of mineralized collagen. [J Mater Sci Mater Med] Abstract

Adhesive Properties of Clostridium perfringens to Extracellular Matrix Proteins Collagens and Fibronectin
The adhesive properties of Clostridium perfringens to collagens, gelatin, fibronectin (Fn), Fn-prebound collagens, and Fn-prebound gelatin were investigated. C. perfringens could bind to Fn-prebound collagen type II, type III, and gelatin, but not to gelatin or collagens except for collagen type I directly. [Anaerobe] Abstract

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Alliqua Announces Transaction with Celgene
Alliqua, Inc. entered into a licensing agreement with Celgene Cellular Therapeutics, a subsidiary of Celgene Corporation, whereby Alliqua received the right to develop and market the advanced wound care products Biovance^® and Extracellular Matrix. [Alliqua, Inc.] Press Release

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PhD Position – Recombinant Collagen Scaffold Design for Tuned Drug Release in Bone Repair (Fraunhofer)

Postdoctoral Fellowship – Immune Regulation by Extracellular Matrix Proteins (Johns Hopkins University)

Postdoctoral Research Fellows (Wake Forest Institute for Regenerative Medicine)

PhD Studentship – Collagen IV and Angiogenesis (University of East Anglia)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

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