Comparative Decellularization and Recellularization of Normal versus Emphysematous Human Lungs Cadaveric human lungs from normal patients and from patients with chronic obstructive pulmonary disease (COPD) were decellularized and found by histochemical and immunohistochemical staining, electron microscopy, and mass spectrometry to retain characteristic histological architecture and extracellular matrix components reflecting either normal or COPD, particularly emphysematous, origin. [Biomaterials] Abstract Direct Cytocidal Effect of Galectin-9 Localized on Collagen Matrices on Human Immune Cell Lines An attempt was made to develop new collagen matrices, which can cause local, contact-dependent immune suppression, using galectin-9 and collagen-binding galectin-9 fusion proteins as active ingredients. [Biochim Biophys Acta] Abstract Developmentally Regulated Collagen/Integrin Interactions Confer Adhesive Properties to Early Postnatal Neural Stem Cells To examine the specific adhesive properties of young stem cells in more detail, neural stem and progenitor cells isolated from embryonic, postnatal day 6, and adult mouse brains were cultured on collagen I. [Biochim Biophys Acta] Abstract Hsp90 Binds Directly to Fibronectin (FN) and Inhibition Reduces the Extracellular Fibronectin Matrix in Breast Cancer Cells Exogenous heat shock protein 90 (Hsp90)β was shown to increase the formation of extracellular FN matrix in the Hs578T cell line, whilst knockdown or inhibition of Hsp90 led to a reduction in the levels of both soluble and insoluble FN and could be partially rescued by addition of exogenous Hsp90β. [PLoS One] Full Article CADM1 Controls Actin Cytoskeleton Assembly and Regulates Extracellular Matrix Adhesion in Human Mast Cells The authors investigated a role for CADM1 in mast cell (MC) adhesion to both cells and extracellular matrix (ECM). Downregulation of CADM1 in the human MC line HMC-1 resulted not only in reduced adhesion to human airway smooth muscle cells, but also reduced adhesion to their ECM. [PLoS One] Full Article Extracellular Matrix Remodeling following Myocardial Infarction Influences the Therapeutic Potential of Mesenchymal Stem Cells Mechanical and compositional changes to the decellularized infarcted myocardium were characterized to understand how the extracellular environment, specifically, was altered as a function of time following coronary artery ligation in Sprague-Dawley rats. [Stem Cell Res Ther] Abstract | Full Article Microablation of Collagen-Based Substrates for Soft Tissue Engineering Through the use of excimer-laser technology, investigators have optimized conditions for the ablation of collagen lamellae without denaturation of protein, maintenance of fibrillar ultrastructure and preservation of native D-periodicity. [Biomed Mater] Abstract |