Integrin αvβ3 and Thyroid Hormones Promote Expansion of Progenitors in Embryonic Neocortex The authors showed that targeted activation of the extracellular matrix receptor integrin αvβ3 on basal progenitors in embryonic mouse neocortex promotes their expansion. [Development] Abstract | Press Release Molecular Adhesion between Cartilage Extracellular Matrix Macromolecules Scientists investigated the molecular adhesion between the major constituents of cartilage extracellular matrix, namely the highly negatively charged proteoglycan aggrecan and the type II/IX/XI fibrillar collagen network, in simulated physiological conditions. [Biomacromolecules] Abstract Heparin Prevents Intracellular Hyaluronan Synthesis and Autophagy Responses in Hyperglycemic Dividing Mesangial Cells and Activates Synthesis of an Extensive Extracellular Monocyte-Adhesive Hyaluronan Matrix after Completing Cell Division The authors showed that heparin inhibits intracellular hyaluronan synthesis and autophagy responses, but at the end of cell division induces synthesis of a much larger extracellular monocyte-adhesive hyaluronan matrix. [J Biol Chem] Abstract | Full Article The Extracellular Matrix Protein Artichoke Is Required for Integrity of Ciliated Mechanosensory and Chemosensory Organs in Drosophila Embryos Researchers identified Artichoke, an evolutionary conserved leucine-rich repeat extracellular matrix protein that is required for normal morphogenesis and function of ciliated sensilla in Drosophila. [Genetics] Abstract Flexibility and Explicit Solvent in Molecular Dynamics-Based Docking of Protein-Glycosaminoglycan Systems The authors aimed to develop a proof of concept for a molecular dynamics-based docking approach and to analyze its applicability for protein-glycosaminoglycans systems. Dynamic Molecular Docking (DMD) exploits the electrostatics-driven attraction of a ligand to its receptor, treats both as entirely flexible and considers solvent explicitly. [J Chem Inf Model] Abstract TAF4 Inactivation Reveals the 3 Dimensional Growth Promoting Activities of Collagen 6A3 Scientists showed that Collagen 6A3 (Col6a3) is highly expressed in densely growing mouse embryonic fibroblasts (MEFs). In MEFs where the TAF4 subunit of general transcription factor IID has been inactivated, elevated Col6a3 expression prevents contact inhibition promoting their three dimensional growth as foci and fibrospheres. [PLoS One] Abstract Extracellular Matrix Density Promotes Epithelial to Mesenchymal Transition by Weakening Cell-Cell Adhesions The authors have developed a computational framework for studying modulation of cell-cell adhesion by extracellular matrix (ECM) density, integrating findings from multiple studies that connect ECM-mediated adhesion signaling and growth factor signaling with cell-cell adhesion. [Mol Biosyst] Abstract Win a $25 Amazon Gift Card! Connexon Creative is evaluating reader interest in a new social media platform. Fill out this quick survey for your chance to win 1 of 4 $25 gift cards! Take survey here |