Targeting Fibronectins of Glioma Extracellular Matrix by CLT1 Peptide-Conjugated Nanoparticles In this study, a drug delivery system targeting fibronectins (FNs), a prevailing component in the extracellular matrix of many solid tumors, was constructed for glioma therapy based on the interaction between the abundant FNs in glioma tissues and the FNs-targeting moiety CLT1 peptide. [Biomaterials] Abstract Oxidation Modifies the Structure and Function of the Extracellular Matrix Generated by Human Coronary Artery Endothelial Cells Researchers investigated the effect of peroxynitrous acid, an oxidant generated by activated macrophages, on the structure and function of the extracellular matrix laid down by human coronary artery endothelial cells in vitro and in vivo. [Biochem J] Abstract Vascular Morphogenesis of Human Umbilical Vein Endothelial Cells on Cell-Derived Macromolecular Matrix Microenvironment Investigators hypothesize that extracellular matrix derived from in vitro cultured cells possesses unique surface texture, topography and mechanical property, and consequently carry some distinct cues for vascular morphogenesis of human umbilical vein endothelial cells. [Tissue Eng Part A] Abstract A Combination of Biphasic Calcium Phosphate Scaffold with Hyaluronic Acid-Gelatin Hydrogel as a New Tool for Bone Regeneration Hyaluronic acid-Gelatin hydrogel was loaded into a biphasic calcium phosphate ceramic, and the resulting scaffold, with unique micro and macro porous orientation, was evaluated for bone regeneration applications. [Tissue Eng Part A] Abstract Non-Replicating Mycobacterium tuberculosis Elicits a Reduced Infectivity Profile with Corresponding Modifications to the Cell Wall and Extracellular Matrix Non-replicating persistent (NRP) M. tuberculosis was established by the gradual depletion of nutrients in an oxygen-replete and controlled environment. In contrast to rapidly dividing bacilli, NRP bacteria exhibited a distinct phenotype by accumulating an extracellular matrix rich in free mycolate and lipoglycans, with increased arabinosylation. [PLoS One] Full Article Opposing Effects of Collagen I and Vitronectin on Fibronectin Fibril Structure and Function The authors compared effects of cell adhesion to vitronectin versus type I collagen on the assembly of and response to, extracellular matrix fibronectin fibrils. The amount of insoluble fibronectin matrix fibrils assembled by fibronectin-null mouse embryonic fibroblasts adherent to collagen- or vitronectin-coated substrates was not significantly different 20 hours after fibronectin addition. [Matrix Biol] Abstract Optimum Temperature for Extracellular Matrix Production by Articular Chondrocytes Researchers investigated the influence of temperature on the ability of the chondrocytes to produce extracellular matrix (ECM). The ability to produce ECM was assessed by gene expression analysis, histological, and biochemical evaluation in a pellet culture system. [Int J Hyperthermia] Abstract Effects of ECM Protein Mimetics on Adhesion and Proliferation of Chorion Derived Mesenchymal Stem Cells Scientists evaluated the effects of fibronectin, collagen, cadherin, and laminin based extracellular matrix (ECM) protein mimetics coated with mussel derived adhesive protein on adhesion and proliferation of chorionic mesenchymal stem cells. [Int J Med Sci] Abstract Win a $25 Amazon Gift Card! Connexon Creative is evaluating reader interest in a new social media platform. Fill out this quick survey for your chance to win 1 of 4 $25 gift cards! Take survey here |