Collagen Nanofibers Facilitated Pre-Synaptic Maturation in Differentiated Neurons from Spinal Cord-Derived Neural Stem Cells through MAPK/ERK1/2- Synapsin I Signaling Pathway Researchers investigated the role of nanofibrous scaffolds on neural stem cells-derived neurons in the formation of neural network. [Biomacromolecules] Abstract RNA Sequencing of Creatine Transporter (SLC6A8) Deficient Fibroblasts Reveals Impairment of the Extracellular Matrix Differential gene expression analysis followed by gene ontology term enrichment analysis revealed that especially the expression of genes encoding components of the extracellular matrix and cytoskeleton are altered in SLC6A8 deficiency, such as collagens, keratins, integrins, and cadherins. [Hum Mutat] Abstract Glycosylation Modulates Melanoma Cell α2β1 and α3β1 Integrin Interactions with Type IV Collagen The galactosylation of Hyl393 in α1(IV)382-393 and Hyl540 and Hyl543 in α1(IV)531-543 had a dose dependent influence on melanoma cell adhesion which was much more pronounced in the case of α3β1 integrin binding. [J Biol Chem] Abstract | Full Article Glycosylation and Cross-Linking in Bone Type I Collagen Researchers quantitatively characterized glycosylation of non-cross-linked and cross-linked peptides by biochemical and nanoscale liquid chromatography – high resolution tandem mass spectrometric analyses. [J Biol Chem] Abstract | Full Article Glycated Collagen Induces α11 Integrin Expression through TGF-β2 and Smad3 Researchers examined how methylglyoxal-glycated collagen regulates α11 integrin expression. In cardiac fibroblasts plated on glycated collagen but not glycated fibronectin, there was markedly increased α11 integrin and α-smooth muscle actin expression. [J Cell Physiol] Abstract The Regulation of TGFβ1 Induced Fibronectin EDA Exon Alternative Splicing in Human Renal Proximal Tubule Epithelial Cells Scientists investigated cellular mechanisms of EDA+ fibronectin production in human primary proximal tubule epithelial cells. [J Cell Physiol] Abstract LL-37 Secreted by Epithelium Promotes Fibroblast Collagen Production: A Potential Mechanism of Small Airway Remodeling in Chronic Obstructive Pulmonary Disease In vitro, the effect of CSE-induced epithelial secretion of LL-37 on collagen production in human lung fibroblasts was studied in a co-culture system. The signaling pathways involved in the effect of LL-37 on fibroblast collagen production were evaluated. [Lab Invest] Abstract Synthesis of Functionalized Poly(Ester Carbonate) with Laminin-Derived Peptide for Promoting Neurite Outgrowth of PC12 cells In vitro culture of PC12 cells showed that maleimide-functionalized polymers, especially CQAASIKVAV-grafted ones, could support cell proliferation and neurite outgrowth. [Macromol Biosci] Abstract Matrix Metalloproteinase-9 Is Involved in Chronic Lymphocytic Leukemia Cell Response to Fludarabine and Arsenic Trioxide It is not known if matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to chemotherapy and scientists address this in the present study, using arsenic trioxide and fludarabine as examples of cytotoxic drugs. [PLoS One] Full Article Perfluorooctanoic Acid Stimulates Breast Cancer Cells Invasion and Up-Regulates Matrix Metalloproteinase-2/-9 Expression Mediated by Activating NF-κB Researchers explored the molecular mechanisms undergoing the stimulation effects of perfluorooctanoic acid on cancer cell invasion and matrix metalloproteinases expression. [Toxicol Lett] Abstract |