Maturation of GDF15 in Human Placental Trophoblast Cells Depends on the Interaction with Matrix Metalloproteinase-26 (MMP-26) Scientists aimed to identify the intracellular binding partners of MMP-26, and to investigate how MMP-26 is involved in placentation through the interactions with its partners. [J Clin Endocrinol Metab] Abstract Naproxen Induces Type X Collagen Expression in Human Bone Marrow Derived Mesenchymal Stem Cells through the Upregulation of 5-Lipoxygenase Researchers determined the effect of naproxen on type X collagen protein expression and investigated the intracellular signaling pathways that mediate naproxen induced type X collagen gene expression in normal and osteoarthritis mesenchymal stem cells. [Tissue Eng Part A] Abstract Regeneration of Uterine Horns in Rats Using Collagen Scaffolds Loaded with Human Embryonic Stem Cell-Derived Endometrium-Like Cells Scientists aimed to efficiently generate endometrium-like cells from human embryonic stem cells and to use these cells with collagen scaffold to repair uterine damage. [Tissue Eng Part A] Abstract Functional Nucleus Pulposus-Like Matrix Assembly by Human Mesenchymal Stromal Cells Is Directed by Macromer Concentration in Photocrosslinked Carboxymethylcellulose Hydrogels Researchers evaluated the influence of carboxymethylcellulose macromer concentration on bulk hydrogel properties and nucleus pulposus-like matrix elaboration by human mesenchymal stromal cells. [Cell Tissue Res] Abstract Low-Intensity Pulsed Ultrasound Activates Integrin-Mediated Mechanotransduction Pathway in Synovial Cells Scientists examined the mechanotransduction pathway via the integrin/mitogen-activated protein kinase (MAPK) pathway in low-intensity pulsed ultrasound exposure on the synovial membrane cells. A possible integrin/MAPK pathway was examined by immunofluorescence and Western blotting analysis with antibodies targeting specific phosphorylation sites on intracellular signaling proteins. [Ann Biomed Eng] Abstract Healing of a Xenogeneic Collagen Matrix for Keratinized Tissue Augmentation Scientists evaluated histologically the healing of a xenogeneic collagen matrix used to augment the width of keratinized tissue around teeth. [Clin Oral Implants Res] Abstract Viability of Chondrocytes Seeded onto a Collagen I/III Membrane for Matrix-Induced Autologous Chondrocyte Implantation Researchers aimed to determine the effect of handling the membrane during matrix-induced autologous chondrocyte implantation surgery on the viability of implanted chondrocytes. [J Orthop Res] Abstract Ureic Clearance Granule, Alleviates Renal Dysfunction and Tubulointerstitial Fibrosis by Promoting Extracellular Matrix Degradation in Renal Failure Rats, Compared with Enalapril Researchers demonstrate the effects and mechanisms of uremic clearance granules on renal dysfunction and tubulointerstitial fibrosis by regulating extracellular matrix degradation and transforming growth factor-beta1/Smad signaling activity in vivo, compared with enalapril. [J Ethnopharmacol] Abstract LRP4 Induces Extracellular Matrix Productions and Facilitates Chondrocyte Differentiation Scientists found that lipoprotein receptor-related protein 4 (LRP4) induced gene expressions of extracellular matrix proteins of type II collagen, aggrecan, and type X collagen, as well as production of total proteoglycans in ATDC5 cells, whereas LRP4 knockdown had opposite effects. [Biochem Biophys Res Commun] Abstract |