β-Arrestins Regulate Human Cardiac Fibroblast Transformation and Collagen Synthesis in Adverse Ventricular Remodeling Investigators hypothesized that β-arrestins play an important role in the regulation of adult human cardiac fibroblasts biology with regard to myofibroblast transformation, increased collagen synthesis, and myocardial fibrosis which are important in the development of heart failure. [J Mol Cell Cardiol] Abstract Effect of FGF-2 on Collagen Tissue Regeneration by Human Vertebral Bone Marrow Stem Cells The effects of fibroblast growth factor-2 (FGF-2) on collagen tissue regeneration by human bone marrow stem cells (hBMSCs) were investigated. The FGF-2 treatment affected the colony-forming efficiency, proliferation, and in vitro differentiation of hBMSCs. [Stem Cells Dev] Abstract A Comparative Study on In Vitro Osteogenic Priming Potential of Electron Spun Scaffold PLLA/HA/Col, PLLA/HA, and PLLA/Col for Tissue Engineering Application A comparative study on the in vitro osteogenic potential of electrospun poly-L-lactide/hydroxyapatite/collagen (PLLA/HA/Col, PLLA/HA, and PLLA/Col) scaffolds was conducted. Cell attachment, distribution, morphology, mineralization, extracellular matrix protein localization, and gene expression of human mesenchymal stromal cells differentiated on the fibrous scaffolds PLLA/Col/HA, PLLA/Col, and PLLA/HA were analyzed. [PLoS One] Full Article Interplay between Cellular Activity and Three-Dimensional Scaffold-Cell Constructs with Different Foam Structure Processed by Electron Beam Melting Scientists combined cellular biology and materials science and engineering to fundamentally elucidate the interplay between cellular activity and interconnected three-dimensional foamed architecture obtained by a novel process of electron beam melting and computational tools. Furthermore, the organization of key proteins, notably, actin, vinclulin, and fibronectin, involved in cellular activity and biological functions and relationship with the structure was explored. [J Biomed Mater Res A] Abstract Resistance to Cigarette Smoke Is Increased in PDL Cells by Attachment to Collagen and Fibronectin Researchers investigated the direct effects of smoking on periodontal ligament (PDL) fibroblasts, focusing on cell-extracellular matrix interactions and cell survival. [J Periodontol] Abstract Gallic Acid Regulates Skin Photoaging in UVB-Exposed Fibroblast and Hairless Mice The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase activity, which is induced by reactive oxygen species production. Scientists investigated the protective effects of gallic acid against photoaging caused by ultraviolet B (UVB) irradiation using normal human dermal fibroblasts in vitro and hairless mice in vivo. [Phytother Res] Abstract Epigalloccatechin-3-Gallate Inhibits Ocular Neovascularization and Vascular Permeability in Human Retinal Pigment Epithelial and Human Retinal Microvascular Endothelial Cells via Suppression of MMP-9 and VEGF Activation Epigalloccatechin-3-gallate treatment significantly decreased mRNA and protein expression levels of matrix metalloproteinases-9 (MMP-9) in the presence of 12-O-tetradecanoylphorbol-13-acetate and tumor necrosis factor alpha in human retinal pigment epithelial cells. [Molecules] Abstract | Download Full Article The Inhibitor of Kappa B Kinase-Epsilon Regulates MMP-3 Expression Levels and Can Promote Lung Metastasis Matrix metalloproteinases (MMP) were identified as potential regulators of the site-specificity of metastasis. Researchers investigated signaling pathways regulating MMP-3 expression and the role that MMP-3 plays in lung metastasis. [Oncogenesis] Full Article |