Delineation of In Vitro Chondrogenesis of Human Synovial Stem Cells following Preconditioning Using Decellularized Matrix Investigators found that expansion on decellularized extracellular matrix full of three-dimensional nanostructured fibers provided synovium-derived stem cells with unique surface profiles, low elasticity but large volume as well as a fibroblast-like shape. [Acta Biomater] Abstract Loss of CD147 Results in Impaired Epithelial Cell Differentiation and Malformation of the Meibomian Gland Scientists identified a novel function for CD147, a transmembrane protein that promotes tissue remodeling through induction of matrix metalloproteinases, in regulating meibocyte differentiation and activity. [Cell Death Dis] Full Article Influence of Vascular Endothelial Growth Factor Stimulation and Serum Deprivation on Gene Activation Patterns of Human Adipose Tissue-Derived Stromal Cells Researchers investigated the effect of in vitro serum deprivation and vascular endothelial growth factor stimulation on gene expression patterns of adipose tissue-derived stromal cells. [Stem Cell Res Ther] Abstract | Full Article Collagen and Elastin Cross-Linking Is Altered during Aberrant Late Lung Development Associated with Hyperoxia Scientists demonstrated that collagen and elastin cross-linking are perturbed during the arrested alveolarization of developing mouse lungs exposed to hyperoxia. [Am J Physiol Lung Cell Mol Physiol] Abstract High-Mobility Group Box 1 Accelerates Lipopolysaccharide-Induced Lung Fibroblast Proliferation In Vitro: Involvement of the NF-κB Signaling Pathway Researchers investigated the effects of lipopolysaccharide (LPS)- and/or high-mobility group box 1 (HMGB1)-stimulating murine lung fibroblasts on gene expression using various assays in vitro. Secretion of matrix metalloproteinase (MMP)-2 and MMP-9, and tissue inhibitor of metalloproteinase 2 was significantly upregulated after treatment with LPS, HMGB1, or their combination. [Lab Invest] Abstract Periodontal Regeneration Employing Gingival Margin-Derived Stem/Progenitor Cells in Conjunction with IL-1ra-Hydrogel Synthetic Extracellular Matrix Scientists investigated the periodontal regenerative potential of gingival margin-derived stem/progenitor cells in conjunction with IL-1ra releasing hyaluronic acid synthetic extracellular matrix [J Clin Periodontol] Abstract Colorectal Cancer Metastases Settle in the Hepatic Microenvironment Through α5β1 Integrin Researchers investigated the role of α5β1 integrin and how the microenvironment influences this adhesion molecule, in a model of colon cancer progression to the liver. [J Cell Biochem] Abstract No Effects of Hyperosmolar Culture Medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells despite Upregulation Extracellular Matrix Genes Investigators determined the effect of osmolality and different osmolytes on the regeneration by human nucleus pulposus cells through gene expression and extracellular matrix production. [Spine] Abstract |