Ex Vivo Engineered Immune Organoids for Controlled Germinal Center Reactions The authors describe a B cell follicle organoid made of nanocomposite biomaterials, which recapitulates the anatomical microenvironment of a lymphoid tissue that provides the basis to induce an accelerated germinal center reaction by continuously providing extracellular matrix and cell-cell signals to naïve B cells. [Biomaterials] Abstract | Press Release Histidine-Rich Glycoprotein Blocks Collagen-Binding Integrins and Adhesion of Endothelial Cells through Low-Affinity Interaction with α2 Integrin Investigators examined the mechanism of action of histidine-rich glycoprotein (HRG)’s effect on endothelial cells (ECs). HRG suppressed adhesion, spreading and migration of ECs specifically on collagen I whereas ECs seeded on other extracellular matrix proteins were insensitive to HRG. [Matrix Biol] Full Article Renal Extracellular Matrix Scaffolds from Discarded Kidneys Maintain Glomerular Morphometry and Vascular Resilience and Retains Critical Growth Factors Resin casting and pulse-wave measurements showed that human renal extracellular matrices preserved the microvascular morphology and morphometry, and physiological function. Moreover, growth factors including vascular endothelial growth factor and its receptors were retained within the matrices. [Transplantation] Abstract | Press Release Interactions between Skeletal Muscle Myoblasts and their Extracellular Matrix Revealed by a Serum Free Culture System The authors describe the efficient decellularization of quadriceps muscle with the retention of matrix components and the use of this matrix for myoblast proliferation and differentiation under serum free culture conditions. [PLoS One] Full Article Accelerated Extracellular Matrix Turnover during Exacerbations of COPD Researchers hypothesized that the turnover of lung extracellular matrix (ECM) proteins were altered during exacerbations of chronic obstructive pulmonary disease (COPD). Competitive ELISAs measuring circulating protein fragments in serum or plasma assessed the formation and degradation of collagen types III, IV, and VI, and degradation of elastin and versican. [Resp Res] Abstract | Full Article Lentiviral Vector-Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion under High Glucose Conditions in Mesangial Cells The expression of major extracellular matrix proteins-FN and Col I- increased under high glucose conditions, consistent with the activation of TGF-β/Smad signaling. By contrast, overexpression of nucleus-localized forkhead transcription factor O1 (FoxO1) directly up-regulated the expressions of anti-oxidative enzymes, accompanied with inactivation of TGF-β/Smad3 pathway, as well as decreases of extracellular matrix proteins. [J Cell Biochem] Abstract Wnt/β-Catenin and MEK-ERK Signaling Are Required for Fibroblast-Derived Extracellular Matrix-Mediated Endoderm Differentiation of Embryonic Stem Cells Investigators determined the effect of a fibroblast-derived extracellular matrix (fd-ECM) on human embryonic stem cells (hESCs) differentiation. They demonstrated that growth of hESCs on fd-ECM results in hESCs losing their stemness and proliferation potential. [Stem Cell Rev] Abstract Fibrin as a Scaffold for Delivery of GDNF Overexpressing Stem Cells to the Adult Rat Brain Scientists sought to determine if a clinically used fibrin scaffold can be utilized as an adjunct to intra-cerebral cell transplantation without evoking an adverse host or stem cell response. They found that fibrin scaffold was adaptable to intra-cerebral delivery with successful polymerization of the fibrin scaffold in situ. [ACS Biomater Sci Eng] Abstract |