Nuclear Envelope Rupture and Repair during Cancer Cell Migration Researchers investigated mammalian tumor cell migration in confining microenvironments in vitro and in vivo. The incidence of nuclear envelope (NE) rupture increased with cell confinement and with depletion of nuclear lamins, NE proteins that structurally support the nucleus. [Science] Abstract | Press Release | Editorial | Video Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration Scientists showed that deleting the SWI/SNF component Arid1a substantially improves mammalian regeneration. Arid1a expression is suppressed in regenerating tissues, and genetic deletion of Arid1a increases tissue repair following an array of injuries. [Cell Stem Cell] Abstract | Graphical Abstract | Press Release Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis Investigators examined the role of CCN5 in human heart failure and tested whether CCN5 can reverse established cardiac fibrosis in an experimental model of heart failure induced by pressure overload. [J Am Coll Cardiol] Full Article | Press Release | Podcast Deflection Induced Cellular Focal Adhesion and Anisotropic Growth on Vertically Aligned Silicon Nanowires with Differing Elasticity Researchers investigated the adhesion and growth of human embryonic kidney 293T cells on vertically aligned silicon nanowires. Varying the diameter of nanowires affected their elasticity, which in turn caused variations in cell morphology and adhesion. [NPG Asia Mater] Full Article Experimental Inhibition of Porcupine-Mediated Wnt O-Acylation Attenuates Kidney Fibrosis Scientists found that inhibiting porcupine dramatically attenuates kidney fibrosis in the murine unilateral ureteral obstruction model. Wnt-C59 treatment similarly blunts collagen mRNA expression in the obstructed kidney. [Kidney Int] Abstract | Press Release Combinatorial Microenvironmental Regulation of Liver Progenitor Differentiation by Notch Ligands, TGFβ, and Extracellular Matrix Utilizing a series of strategies, including co-cultures and cellular microarrays, researchers identified distinct contributions of different Notch ligands and extracellular matrix proteins in the fate decisions of bipotential mouse embryonic liver progenitor cells. [Sci Rep] Full Article Receptor Activator of NF-κB Ligand Induces Cell Adhesion and Integrin α2 Expression via NF-κB in Head and Neck Cancers The authors report a novel role for receptor activator of NF-κB ligand (RANKL) in the regulation of cell adhesion. Among the major type I collagen receptors, integrin α2 was significantly upregulated in RANKL-expressing cells, and its knockdown suppressed cell adhesion. [Sci Rep] Full Article Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis Investigators have developed a protocol for the efficient generation of large, 3D-stratified retinal organoids that does not require evagination of optic-vesicle-like structures, which so far limited the organoid yield. [Stem Cell Rep] Full Article | Graphical Abstract | Press Release A Human Amnion-Derived Extracellular Matrix-Coated Cell-Free Scaffold for Cartilage Repair: In Vitro and In Vivo Studies Researchers developed a novel human amniotic mesenchymal cell-derived extracellular matrix-coated polylactic-co-glycolic acid scaffold, examined its property on mesenchymal cells, and investigated its potential as a cell-free scaffold for cartilage repair. [Tissue Eng Part A] Abstract RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells Scientists investigated the contribution of receptor of AGEs (RAGE) and TGF-β1 to the modulation of inflammatory response and extracellular matrix turnover in AGEs milieu, using a normal fibroblast cell line. [PLoS One] Full Article Chondrogenic Differentiation of Mesenchymal Stem Cells on Glycosaminoglycan-Mimetic Peptide Nanofibers Mesenchymal stem cells cultured on glycosaminoglycan (GAG)-mimetic peptide nanofibers formed cartilage-like nodules and deposited cartilage-specific matrix components by day seven, suggesting that the GAG-mimetic peptide nanofibers effectively facilitated their commitment into the chondrogenic lineage. [ACS Biomater Sci Eng] Abstract |