Extracellular Matrix News Volume 7.21 | Jun 2 2016

TOP STORY

Heparinized Collagen Sutures for Sustained Delivery of PDGF-BB: Delivery Profile and Effects on Tendon-Derived Cells In Vitro

Researchers reconstituted collagen solutions as suturable collagen threads by using linear electrochemical compaction. Proliferation of cells seeded on platelet derived growth factor-BB (PDGF-BB) incorporated collagen sutures was about 50% greater than those seeded on plain collagen sutures [Acta Biomater] Abstract

(Ranked by impact factor of the journal)

The Effect of Gradations in Mineral Content, Matrix Alignment, and Applied Strain on Human Mesenchymal Stem Cell Morphology within Collagen Biomaterials

The combined influence of graded biomaterial environment and increasing levels of applied strain on mesenchymal stem cell orientation and alignment are reported. [Adv Healthc Mater] Abstract

Repair of Large Osteochondritis Dissecans Lesions Using a Novel Multilayered Tissue Engineered Construct in an Equine Athlete

Researchers investigated the use of a scaffold-assisted microfracture approach, employing a novel, multilayered, collagen-based, osteochondral graft substitute in the treatment of severe osteochondritis dissecans of both lateral femoral trochlear ridges in an equine athlete, and to assess the potential of this novel scaffold to enhance repair of the osteochondral unit. [J Tissue Eng Regen Med] Abstract

Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries

Investigators developed and test a stent surface polymer, where cytotoxic drugs are covalently conjugated to the surface and released by proteases selectively secreted by proliferating smooth muscle cells. [Mol Pharm] Abstract

Three-Dimensional Hierarchical Cultivation of Human Skin Cells on Bio-Adaptive Hybrid Fibers

Researchers fabricated biocompatible hybrid fibers simulating the complex biomechanical characteristics of native extracellular matrix in human skin. Subsequently, they analyzed interactions of such fibers with human skin cells focusing on the identification of key fiber characteristics for optimized cell–matrix interactions. [Integr Biol] Abstract

Relevance of Charge Balance and Hyaluronic Acid on Alginate-Chitosan Sponge Microstructure and Its Influence on Fibroblast Growth

Scientists prepared sponges composed of chitosan/alginate with or without hyaluronic acid by mixing polymer stock solutions of different net electric charge ratios, and then lyophilizing them in order to obtain porous materials. [J Biomed Mater Res A] Abstract

Interactions among Lung Cancer Cells, Fibroblasts, and Macrophages in 3D Co-Cultures and the Impact on MMP-1 and VEGF Expression

A three-dimensional (3D) cell co-culture collagen gel model was employed, containing human lung adenocarcinoma cells, human lung fibroblast cells, and macrophages. Cell culture media and cell images were collected, and matrix metalloproteinase-1 (MMP-1) and vascular endothelial growth factor (VEGF) production was monitored under different cell culture conditions. [PLoS One] Full Article

Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes

With the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney cell line or bone marrow stromal stem cells. [Ann Biomed Eng] Abstract

Gene Transfection of Human Mesenchymal Stem Cells with a Nano-Hydroxyapatite–Collagen Scaffold Containing DNA-Functionalized Calcium Phosphate Nanoparticles

Scientists aimed to fabricate a growth factor-releasing biodegradable scaffold for tissue regeneration. They prepared multishell calcium phosphate nanoparticles functionalized with DNA, polyethyleneimine, protamine and octa-arginine and compared their respective transfection activity and cell viability measures using human mesenchymal stem cells. [Genes Cells] Abstract

Osteocytic Signaling Pathways as Therapeutic Targets for Bone Fragility

The discovery of mutations in human osteocytic genes has contributed, in a large part, to the understanding of the role of osteocytes in bone homeostasis. Osteocytes are targets of the mechanical force imposed on the skeleton and have a critical role in integrating mechanosensory pathways with the action of hormones, which thereby leads to the orchestrated response of bone to environmental cues. [Nat Rev Endocrinol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

SBH Sciences and n3D to Start Partnership to Offer 3D Bioprinting for Lead Compound Optimization

SBH Sciences (SBH) is partnering with Nano3D Biosciences (n3D) to offer innovative solutions and services using assays based on magnetic 3D Bioprinting. SBH will offer n3D’s wound healing assay model as an expansion of its portfolio of cell-based assays for cytokines/anti-cytokines and fibrosis detection. [SBH Sciences (PR Newswire Association LLC.)] Press Release

Symic Appoints Alyssa Panitch, Ph.D., as Chair of Scientific Advisory Board

Symic announced that Alyssa Panitch, Ph.D., one of the founders of the company and an inventor of Symic’s technology, has been appointed to chair the company’s Scientific Advisory Board. [Symic Biomedical, Inc.] Press Release

NEW Skeletal Muscle Satellite Cells and Regeneration
July 24-29, 2016
Keystone, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

NEW Postdoctoral Research Fellow – Musculoskeletal Regenerative Medicine (Queen Mary University of London)

Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Scientist – Intracellular Calcium Cycling (Cedars-Sinai Heart Institute)

Postdoctoral Position – Vascular Remodeling (Scripps Research Institute)

Postdoctoral Position – Biomechanics (Massachusetts General Hospital & Harvard Medical School)

Postdoctoral Fellow – Genome Editing for Striated Muscle Regeneration (Duke University)

MSc Position – Extracellular Matrix Genes during Aging (ETH Zurich)

PhD Position – Extracellular Matrix Genes during Aging (ETH Zurich)

Postdoctoral Position – Extracellular Matrix Genes during Aging (ETH Zurich)

Postdoctoral Position – Motor Plasticity and Repair (Burke Medical Research Institute)

Postdoctoral Position – Cancer Biology/Immunology (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow – Cervical Extracellular Matrix (University of Texas Southwestern Medical Center)

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