Extracellular Matrix News Volume 8.38 | Sep 28 2017

TOP STORY

Hof1 and Chs4 Interact via F-BAR Domain and Sel1-Like Repeats to Control Extracellular Matrix Deposition during Cytokinesis

Investigators showed that Hof1 binds to the Sel1-like repeats of chitin synthase-IV (Chs4) via its F-BAR domain and inhibited Chs3-mediated chitin synthesis during cytokinesis. [Curr Biol] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Nonmineralized and Mineralized Collagen Scaffolds Induce Differential Osteogenic Signaling Pathways in Human Mesenchymal Stem Cells

While DMH1 inhibited runt-related transcription factor 2 (Runx2) and bone sialoprotein II (BSPII) gene expression of primary human mesenchymal stem cells on mineralized collagen glycosaminoglycan scaffolds, PD98059 inhibits BSPII expression on Col-GAG independent of Runx2 expression. [Adv Healthc Mater] Abstract

Long Noncoding RNA CIR Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis by Acting as a Sponge for Mir-27b

Overexpression of lncRNA-CIR significantly increased the expression of MMP13, while miR-27 remarkably suppressed the expression of MMP13, accompanied with increases of mRNA level, protein level and relative luciferase activity. [Cell Physiol Biochem] Full Article

Solubilized Amnion Membrane Hyaluronic Acid Hydrogel Accelerates Full-Thickness Wound Healing

Investigators describe a novel amnion membrane-derived product, processed to result in a cell-free solution, while maintaining high concentrations of cell-derived cytokines and growth factors. [Stem Cells Transl Med] Full Article

Imaging Stem Cell Distribution, Growth, Migration, and Differentiation in 3-D Scaffolds for Bone Tissue Engineering Using Mesoscopic Fluorescence Tomography

The authors utilized angled fluorescence laminar optical tomography, which allows depth-resolved molecular characterization of engineered tissues in three-dimensional to investigate cell viability, migration and bone mineralization within bone tissue engineering scaffolds in situ. [Biotechnol Bioeng] Abstract

In Situ Bone Tissue Engineering with an Endogenous Stem Cell Mobilizer and Osteoinductive Nanofibrous Polymeric Scaffolds

To bypass the ex vivo cell culture and transplantation process, scientists exploited the regenerative capacity of the host by mobilizing endogenous stem cells to the site of injury. Systemic injection of substance P induced mobilization of CD29⁺ CD105⁺ CD45⁻ cells from bone marrow and enhanced bone tissue regeneration in a critical-sized calvarial bone defect model. [Biotechnol J] Abstract

Shear Stress-Mediated Changes in the Expression of Complement Regulatory Protein CD59 on Human Endothelial Progenitor Cells by ECM-Integrinα_Vβ₃-F-Actin Pathway In Vitro

Researchers observed shear stress-mediated changes in the expression of complement regulatory proteins CD46, CD55, and CD59 on human endothelial progenitor cells and focused on the mechanical transmission mechanism in transformed cells in response to the ECM-F-actin pathway in vitro. [Biochem Biophys Res Commun] Abstract

Fibroblast Growth Factor 21 Protects Rat Cardiomyocytes from Endoplasmic Reticulum Stress by Promoting the Fibroblast Growth Factor Receptor 1-Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway

The authors demonstrated that mild endoplasmic reticulum stress resulted in upregulated expression levels of FGF21 and its main receptors, as a response to cell compensation, at the induction of ≤5 µM tunicamycin. [Int J Mol Med] Abstract

TMEM88 Inhibits Extracellular Matrix Expression in Keloid Fibroblasts

Scientists investigated the effects of transmembrane protein 88 (TMEM88) on keloid-derived fibroblasts proliferation and ECM expression, and explored the underlying mechanism. [Biomed Pharmacother] Abstract

Adipose-Derived Stem Cells Express Higher Levels of Type VII Collagen under Specific Culture Conditions

Based on the observations that K14 was expressed in undifferentiated adipose-derived stem cells (ADSCs) and the expression was downregulated after differentiation into adipocytes, researchers speculated that ADSCs are keratinocyte stem/progenitor cells. ADSCs were co-cultured with fibroblasts on type IV collagen in a medium containing all-trans retinoic acid and bone morphogenetic protein 4. [Arch Dermatol Res] Abstract

Silk Scaffolds in Bone Tissue Engineering: An Overview

Several successful works, both in vitro and in vivo, have been reported using silk-based scaffolds to regenerate bone tissues or other parts of the skeletal system such as cartilage and ligament. [Acta Biomater] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

BioLife Solutions CryoStor^® Cell Freeze Media Embedded in Cellular Biomedicine Group Clinical Trial of AlloJoin™

BioLife Solutions, Inc. announced that Cellular Biomedicine Group (CBMG) has validated BioLife’s proprietary CryoStor freeze media for use in CBMG’s planned US Phase I clinical trial of AlloJoin, an off the shelf allogeneic stem cell therapy for knee osteoarthritis. [BioLife Solutions, Inc.] Press Release

Humacyte Receives Award from the Medical Technology Enterprise Consortium

Humacyte has received approximately $650,000 from the Medical Technology Enterprise Consortium. This award will help fund the ongoing development and future commercialization of Humacyte’s bioengineered HAV’s application as a conduit for hemodialysis in patients with end-stage renal disease. [Humacyte, Inc.] Press Release

How the Latest US Travel Ban Could Affect Science

The latest version of US President Donald Trump’s travel ban could make it harder for researchers from several countries to enter the United States to attend scientific meetings, perform research or visit relatives. [Nature News] Editorial

What’s the Evidence? Congress Struggles to Understand New Report on Evidence-Based Policy

Every member of Congress probably wants to use evidence to make better policy. But a hearing suggests it might be a mistake to press lawmakers for details, or ask what they mean by evidence. [ScienceInsider] Editorial

Senate Panel Blocks NIH from Revising Translational Research Awards

A congressional spending panel has backed scientists running a $516 million network of bench-to-bedside research centers in their fight with the National Institutes of Health (NIH) in Bethesda, Maryland, over how it manages the network. It’s the latest step in a long-running tug-of-war over the direction of the Clinical and Translational Science Awards program. [ScienceInsider] Editorial

Canada Names New Chief Science Adviser

Mona Nemer, a cardiology researcher and vice-president of research at the University of Ottawa, has been named Canada’s new Chief Science Adviser by Prime Minister Justin Trudeau. [ScienceInsider] Editorial

What Germany’s Election Results Mean for Science

As Germany reels from an unexpected surge for the far right in the elections, researchers don’t expect much effect on the country’s generous support for science. But with smaller parties standing to gain political influence, battles over issues such as the regulation of gene-edited organisms and how to cut greenhouse-gas emissions could grow fiercer. [Nature News] Editorial

NEW EMBO-EMBL Symposia: Microtubules: From Atoms to Complex Systems
May 27-30, 2018
Heidelberg, Germany

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NEW Postdoctoral Position – ECM Interactions in Cardiovascular Development and Congenital Heart Disease (Thomas Jefferson University)

Assistant or Associate Professor – Biomedical Engineering (University of British Columbia)

Postdoctoral Position – Wound Healing (University of Connecticut Health Center)

Postdoctoral Research Fellowship – Kidney Disease (Vanderbilt University Medical Center)

Faculty Position – Regenerative Biology (Northwestern University)

Postdoctoral Research Scientist – Cancer Research (Cancer Research UK Beatson Institute)

Research Fellow – Discovery and Functionalization of Novel Peptides (Duke-NUS Graduate Medical School)

Postdoctoral Researchers – Cancer Metastasis and Drug Resistance (Tufts University)

Masters Student – Fabrication and Investigation of Nano-Bio Interfaces (Luxembourg Institute of Science and Technology)

Assistant Professor – Stem Cell and Regenerative Biology (Harvard University)

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