Extracellular Matrix News 9.38 September 27, 2018 | |
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TOP STORYMechanosensing by β1 Integrin Induces Angiocrine Signals for Liver Growth and Survival The authors used the developing liver as a model organ to study angiocrine signals and showed that the growth rate of the liver correlates both spatially and temporally with blood perfusion to this organ. By manipulating blood flow through the liver vasculature, they demonstrated that vessel perfusion activates β1 integrin and vascular endothelial growth factor receptor 3. [Nature] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The Hippocampal Extracellular Matrix Regulates Pain and Memory after Injury Investigators showed structural and biochemical plasticity in the hippocampal ECM that is linked to behavioral, cellular, and synaptic changes in a mouse model of chronic pain. [Mol Psychiatry] Abstract Scientists report that a subset of long-lived and flat clathrin-coated structures, also termed plaques, are contractility-independent mechanosensitive signaling platforms. They observed that plaques assemble in response to increasing substrate rigidity and that this is independent of focal adhesions, actin and myosin-II activity. [Nat Commun] Full Article Synchronized Mechanical Oscillations at the Cell-Matrix Interface in the Formation of Tensile Tissue The authors used a fibroblast-generated tissue that is structurally and mechanically matched to embryonic tendon to demonstrate homeostasis of cell-derived and external strain-derived tension over repeated cycles of strain and relaxation. [Proc Natl Acad Sci USA] Abstract Investigators studied the effect of fucoidan on the growth of uterine leiomyomas activated by transforming growth factor beta. They used ELT-3 and human uterine smooth muscle cells as in vitro models. [Cell Physiol Biochem] Full Article Researchers investigated biomechanical interactions that may accompany invasive spread of melanoma cells. They found that metastatic cells can exert considerable traction forces and modify local collagen organization within a 3D matrix. [Sci Rep] Full Article Scientists contrasted cytoskeletal reorganization, epigenetic reprogramming, signaling transduction, and changes in miR profiles in primary human aortic smooth muscle cells between unstressed cells and cells exposed to shear stress. [J Cell Physiol] Abstract The authors investigated the role of miR-30d in regulating apoptosis and the extracellular matrix degradation of nucleus pulposus cells, along with the potential underlying molecular mechanism. [Chem Biol Interact] Abstract Researchers determined differences in growth processes among human induced pluripotent stem cell (hiPSC) lines in suspension culture. Using an hiPSC aggregate suspension culture system, hiPSCs from different lines formed multicellular aggregates classified as large compact or small loose based on their size and morphology. [J Biosci Bioeng] Abstract When implanted into ablated murine tibialis anterior muscle, aligned nanofibrillar scaffolds, in conjunction with voluntary caged wheel exercise, significantly improved the density of perfused microvessels, in comparison to treatments of the randomly oriented nanofibrillar scaffold, decellularized scaffold, or in the untreated control group. [npj Regen Med] Full Article Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSThe Emerging Role of ADAM Metalloproteinases in Immunity The authors review recent insights into the molecular activation, substrate specificity and function of a disintegrin and metalloproteinase (ADAM) proteins in the development and regulation of the immune system, with a particular focus on the roles of ADAM10 and ADAM17. [Nat Rev Immunol] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSPluristem Therapeutics Inc. announced that the FDA has granted Orphan Drug Designation to the company’s PLX cell therapy for the treatment of graft failure and incomplete hematopoietic recovery following hematopoietic cell transplantation. [Pluristem Therapeutics Inc.] Press Release Synergy Biomedical Announces FDA Clearance of BIOSPHERE® FLEX Synergy Biomedical, LLC announced that it has received FDA 510(k) clearance of BIOSPHERE® FLEX. Based on Synergy’s patented BioSphere® Technology, BIOSPHERE® FLEX is a strip-format bone graft product composed of porous, bioactive glass that is dimensionally integrated within a collagen and sodium hyaluronate scaffold. [Synergy Biomedical, LLC (Business Wire, Inc.)] Press Release | |
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POLICY NEWSFrance Seeks Slim Rise to Research Budget Amid Spending Cuts The French government has called for a modest increase to its higher education and research budget for 2019 as it strives to rein in public spending amid a sluggish economic growth forecast. [Nature News] Editorial Why Chinese Medicine Is Heading for Clinics around the World For the first time, the World Health Organization will recognize traditional medicine in its influential global medical compendium. [Nature News] Editorial Science Learns from Its Mistakes Too Scientific studies should always be published irrespective of their result. That is one of the conclusions of a research project conducted by the German Centre for the Protection of Laboratory Animals at the German Federal Institute for Risk Assessment, the results of which have now been published in the journal PLOS ONE. [EurekAlert!] Editorial Six Months to Brexit: How Scientists Are Preparing for the Split The incredible is fast becoming the inevitable. Just six months from now, unless a political earthquake intervenes, the United Kingdom must leave the European Union. Yet the details of the March 2019 break-up are still muddy, and scientists are growing increasingly anxious — and angry — about how Brexit will alter their research and their lives. [Nature News] Editorial
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EVENTSNEW Gordon Research Conference: Cartilage Development and Regeneration and Their Implications in Disease Therapies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Bone Regeneration (University of Michigan) Tenure Track Assistant Professor – Biochemistry and Life Sciences (University of Delaware) Group Leader – Organoid Modelling of Disease (European Molecular Biology Laboratory) Tenure-Track Faculty Position – Cell Signaling & ECM (University of Rochester) Postdoctoral Position – Extracellular Matrix Research (University of Pennsylvania) Postdoctoral Position – Cutaneous Wound Repair (University of Pennsylvania) Faculty Positions – Biomedical Research (Memorial Sloan Kettering Cancer Center) Postdoctoral Scholar – Cellular Mechanobiology (Washington University in St. Louis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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