Hematopoiesis News Volume 1.04 | Feb 9 2010

TOP STORY

Donor Activating KIR3DS1 is Associated with Decreased Acute Graft-Versus-Host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation
The natural killer cell receptor KIR3DS1 is associated with improved outcome in malignancies, infections, and autoimmune diseases, but data for the impact of KIR3DS1 in hematopoietic stem cell transplantation (HSCT) are inconsistent. Using genomic DNA from the National Marrow Donor Program, researchers performed donor KIR genotyping for 1087 patients who received an unrelated HSCT. [Blood]

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SCIENCE NEWS

Leukemia Vaccine Under Development in the United Kingdom
British scientists have developed a vaccine treatment for leukemia that can be used to stop the disease returning after chemotherapy or bone marrow transplant. The vaccine is due to be assessed on patients for the first time. [Press Release from Biotech Daily discussing online prepublication in Cancer Immunology Immunotherapy]

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LABORATORY RESEARCH

Adult T Cell Leukemia/Lymphoma Development in HTLV-1-Infected Humanized SCID Mice
HTLV-1 infected humanized NOD/SCID mice were generated by inoculation of NOD/SCID mice with CD34⁺ hematopoietic progenitor and stem cells infected ex vivo with HTLV-1. [Blood]

Relapse of Leukemia with Loss of Mismatched HLA due to Uniparental Disomy Following Haploidentical Hematopoietic Stem Cell Transplantation
Researchers investigated HLA expression on leukemic cells derived from patients at diagnosis and relapse after hematopoietic stem cell transplantation using flow cytometry with locus-specific antibodies. [Blood]

Leukemogenic Transformation by HOXA-Cluster Genes
Here, researchers performed a comprehensive assessment of the oncogenic potential of every HOXA gene in primary hematopoietic cells. [Blood]

Gfi-1B Controls Human Erythroid and Megakaryocytic Differentiation by Regulating Transforming Growth Factor(beta) Signaling at the Bipotent Erythro-Megakaryocytic Progenitor Stage
In humans, Gfi-1B controls the development of erythrocytes and megakaryocytes by regulating the proliferation and differentiation of bipotent erythro-megakaryocytic progenitors. Researchers further identify in this cell population, the type III transforming growth factor-beta receptor gene, TGFBR3, as a direct target of Gfi-1B. [Blood]

Aberrant Overexpression and Function of the miR-17-92 Cluster in Mixed Lineage Leukemia-Rearranged Acute Leukemia
Researchers have found that microRNA-17-92 cluster (miR-17-92) is frequently amplified and the miRNAs are aberrantly overexpressed in mixed lineage leukemia-rearranged acute leukemias. [Proc Natl Acad Sci U S A]

Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of Toll-Like Receptor Signaling
Researchers report that endotoxin treatment in vivo induces TLR4, MyD88, and Toll/IL-1 resistance domain-containing adaptor-inducing IFN-beta-dependent expansion of bone marrow hematopoietic stem and progenitor cells. [J Immunol]

Myeloid Translocation Gene-16 Interacts with Notch Transcription Complex Components to Integrate Notch Signaling in Hematopoietic Cell Fate Specification
Researchers show that the transcriptional co-repressor, MTG16, interacts with CSL, a transcriptional repressor, and the intracellular domains of Notch receptors, suggesting a pivotal role in regulation of the Notch transcription complex. [Mol Cell Biol]

CLINICAL RESEARCH

Long-Term Outcome and Late Effects in Patients Transplanted with Mobilised Blood or Bone Marrow: a Randomised Trial
Long-term data on outcome and late effects of peripheral blood progenitor cell transplantation (PBPCT) compared with bone marrow transplantation (BMT) are scarce. Here, researchers present long-term data from a randomised study comparing PBPCT with BMT. [Lancet Oncol]

Risk Factors for Fungal Pulmonary Infections in Hematopoietic Stem Cell Transplantation Recipients: The Role of Iron Overload
The aim of this study was to evaluate the risk factors of fungal pulmonary infections due to hematopoietic stem cell transplantation. [Bone Marrow Transplant]

Post-Hematopoietic Stem Cell Transplant Immunization Practices in the Pediatric Blood and Marrow Transplant Consortium
Researchers surveyed the principal investigators of the Pediatric Blood and Marrow Transplant Consortium to identify immunization practice patterns after hematopoietic stem cell transplant and assess compliance with the 2000 Centers for Disease Control and Prevention guidelines. [Pediatr Blood Cancer]

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INDUSTRY NEWS

University of Southern California Stem Cell Researchers Receive Funding
Keck School of Medicine of the University of Southern California researchers Qi-Long Ying and Gregor Adams are the recipients of a National Institutes of Health grant and an American Society of Hematology award that will enhance their individual work in stem cell research and therapy development. [University of Southern California Press Release]

Stem Cells: Science, Economy Edge Religion at the Polls
When it comes to stem cell research as a political issue, Wisconsin voters are more likely to be motivated by ideas of economic benefit and scientific progress than by religious objections, according to a new report. [University of Wisconsin-Madison Press Release]

Progenics Presents Novel Multiplex PI3-Kinase Inhibitors at American Association for Cancer Research Conference on Protein Translation and Cancer
Progenics Pharmaceuticals, Inc. announced the presentation of preclinical data on a series of novel compounds that simultaneously blocked two critical pathways involved in the growth and survival of cancer cells. [Progenics Pharmaceuticals Inc. Press Release]

Geisinger Medical Center Designated as National Marrow Donation Program Collection Site to Collect Bone Marrow from Willing Donors
Geisinger Medical Center was recently designated a National Marrow Donation Program collection site, becoming the only site in the region to collect bone marrow or blood stem cells from willing donors. [The Medical News]

‘Clique’ of Scientists Skewing Stem Cell Research by Influencing High-Profile Journals
A small clique of scientists are skewing stem cell research by unduly influencing which breakthroughs get published in high-profile journals, experts have warned. [Telegraph]

Stem Cell Therapy Closes Merger with Histostem
Stem Cell Therapy International Inc. completed its merger with Histostem Ltd. of South Korea. [Tampa Bay Business Journal]

Roche Allies with Massachusetts General Hospital and Harvard to Develop Stem Cell-Derived Cell Lines for Drug Discovery
Roche is teaming up with the Massachusetts General Hospital and Harvard University to develop new stem cell-based cell lines as disease models for early drug candidate testing. [Genetic Engineering and Biotechnology News]

POLICY NEWS

Impersonation of MHRA Staff [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Public Consultation (MLX 366): Intention to Amend the Medicines for Human Use (Prescribing by European Economic Area Practitioners) Regulations 2008 (SI 2008/1692) [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Waivers for Conflicts of Interest for the February 22, 2010 Vaccines and Related Biological Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States]

Notice of Availability of Administrative Supplements for R25 Science Education Grants (NOT-DA-10-007) [National Institutes of Health, United States]

Recovery Act Limited Competition: Program to Enhance National Institutes of Health-Supported Global Health Research Involving Human Subjects (S07) (RFA-OD-10-006) [National Institutes of Health, United States]

Institutional Clinical and Translational Science Award (U54) (RFA-RM-10-001) [National Institutes of Health, United States]

IACUC 101 Workshop and PRIM&R 2010 IACUC Conference: March 21-23, 2010 in Baltimore, MD (NOT-OD-10-059) [National Institutes of Health, United States] 

Delays in Grant Application Submission Due to Blizzard (NOT-OD-10-060) [National Institutes of Health, United States]

Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002) [National Institutes of Health, United States]
 
Investigator Initiated Multi-Site Clinical Trials (Collaborative R01) (PAR-10-096) [National Heart, Lung, and Blood Institute, United States]

National Institute of Diabetes and Digestive and Kidney Diseases Centers of Excellence in Molecular Hematology (P30) (RFA-DK-09-013) [National Institute of Diabetes and Digestive and Kidney Diseases, United States]

2010 Bone Marrow Transplant (BMT) Tandem Meetings
February 24-28, 2010
Orlando, United States

36th Annual Meeting of the European Group for Blood & Marrow Transplantation (EBMT)
March 21-24, 2010
Vienna, Austria

12th Biennial Canadian Blood and Marrow Transplant Group (CBMTG) Conference
April 7-10, 2010
Vancouver, Canada

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
June 26-July 1, 2010
Berlin, Germany

Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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