Hematopoiesis News Volume 1.17 | May 11 2010

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    Hematopoiesis News 1.17, May 11, 2010.  
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    The Inositol Phosphatase SHIP-1 is Negatively Regulated by Fli-1 and its Loss Accelerates Leukemogenesis
    In this study, researchers have shown that F-MuLV-infected SHIP-1 knockout mice display accelerated erythroleukemia progression. [Blood]

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    SCIENCE NEWS

    Drinking While Pregnant Tied to Rare Leukemia in Offspring
    Pregnant woman may have another reason to avoid drinking, with a new study finding that alcohol use during pregnancy ups the risk for a rare blood cancer in children. [Press release from Yahoo! discussing online prepublication in Cancer Epidemiology, Biomarkers & Prevention]

    Leukaemia Busters Scientists Make Research Breakthrough
    Scientists working in The Simon Flavell Leukaemia Research Laboratory at Southampton General Hospital have made a breakthrough discovery on how to increase the potency of immunotoxin treatment by over one million-fold for certain types of leukemia and lymphoma. [Leukaemia Busters Press Release]

    Anemia Drugs Hold Dangers for Kidney Patients
    The powerful drugs used to fight anemia caused by kidney failure increase the risk for cardiovascular problems such as heart attack, a major study has found. [Press release from Bloomberg Businessweek discussing online prepublication in Annals of Internal Medicine]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor)

    LABORATORY RESEARCH

    Live Imaging of Runx1 Expression in the Dorsal Aorta Tracks the Emergence of Blood Progenitors from Endothelial Cells
    By time-lapse microscopy of Runx1-enhanced green fluorescent protein transgenic zebrafish embryos, researchers were able to capture a subset of cells within the ventral endothelium of the dorsal aorta, as they acquire hemogenic properties, and directly emerge as presumptive hematopoietic stem cells. [Blood]

    Opposing Roles of Polycomb Repressive Complexes in Hematopoietic Stem and Progenitor Cells
    Researchers have investigated the role of polycomb repressive complexes in hematopoietic stem cells and progenitor populations. [Blood]

    Modeling Reveals Bistability and Low-Pass Filtering in the Network Module Determining Blood Stem Cell Fate
    The analysis not only reveals new insights into hematopoietic stem cell regulatory network functionality but also provides a novel and widely applicable strategy to incorporate experimental measurements into dynamical network models. [PLoS Comput Biol]

    Expression of a Src-Family Kinase in CML Cells Induces Resistance to Imatinib in a Kinase-Dependent Manner
    Here researchers tested whether Hck overexpression is sufficient to induce imatinib resistance using both wild-type Hck and a mutant (Hck-T338A) that is uniquely sensitive to the pyrazolo-pyrimidine inhibitor, NaPP1. [J Biol Chem]

    Protein Arginine Methyltransferase 1 Suppresses Megakaryocytic Differentiation Via Modulation of the p38 Mitogen-Activated Protein Kinase Pathway in K562 Cells
    Researchers propose modulation of the p38 MAP kinase pathway by protein arginine methyltransferase 1 as a novel mechanism regulating megakaryocytic differentiation. This study thus provides a new perspective on the promotion of megakaryopoiesis. [J Biol Chem]

    CLINICAL RESEARCH

    Cytogenetics of Childhood Acute Myeloid Leukemia: United Kingdom Medical Research Council Treatment Trials AML 10 and 12
    This cytogenetic study of 729 childhood patients classified them into 22 subgroups and evaluated their incidence and risk of childhood acute myeloid leukemia. [J Clin Oncol]

    Deletions of the Derivative Chromosome 9 Do Not Influence the Response and the Outcome of Chronic Myeloid Leukemia in Early Chronic Phase Treated With Imatinib Mesylate: GIMEMA CML Working Party Analysis
    To investigate the prognostic value of der(9) deletions in early chronic-phase chronic myeloid leukemia (CML), researchers performed an analysis of three prospective imatinib trials of the Italian Group for Hematological Malignancies of the Adult (GIMEMA) CML Working Party. [J Clin Oncol]

    A Novel Prognostic Model in Elderly Patients with Acute Myeloid Leukemia – Results of 909 Patients Entered into the Prospective AML96 Trial
    Researchers present an analysis of potential prognostic factors derived from a large multicenter trial performed in patients with acute myeloid leukemia older than 60 years. [Blood]

    Extent of Alcohol Consumption among Adult Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study
    This study aimed to identify subgroups of childhood cancer survivors at highest risk of consuming alcohol, consuming above recommended weekly levels, and consuming potentially harmful amounts and compare survivor risks with those expected from the general population. [Cancer Epidemiol Biomarkers Prev]

    INDUSTRY NEWS

    Glaxo’s ‘Red Wine’ Drug Trial Halted Over Safety Concerns
    In a possible setback for scientists attempting to make drugs out of a substance found in red wine, GlaxoSmithKline PLC said a clinical trial of one drug in cancer patients has been halted due to safety concerns. [The Wall Street Journal]

    S*BIO and Onyx Pharmaceuticals Announce Expanded Development Collaboration for JAK2 Inhibitors
    S*BIO Pte Ltd and Onyx Pharmaceuticals, Inc. announced the expansion of their development collaboration and option and license commercialization agreement for S*BIO’s novel JAK2 inhibitors, SB1518 and SB1578, also known as ONX 0803 and ONX 0805, respectively. [Onyx Pharmaceuticals, Inc. Press Release]

    POLICY NEWS

    NIH Starts to Flesh out Drug Development Program
    Lawmakers began discussing the details of a newly created drug development program at the National Institutes of Health (NIH). NIH Director Francis Collins told a Senate panel that he’s eager to get started-once the program has a budget. [National Institutes of Health, United States]

    Notice of Funding Opportunity for a Cell Characterization Core for the National Heart, Lung and Blood Institute Progenitor Cell Biology Consortium (NOT-HL-10-109) [National Institutes of Health, United States]

    Notice of Intent to Publish Request for Applications for the Blood and Marrow Transplant Clinical Trials Network Data Coordinating Center (U10) (NOT-HL-10-108) [National Institutes of Health, United States]

    Enhancing Peer Review: Expectation for Service on NIH Peer Review and Advisory Groups (NOT-OD-10-089) [National Institutes of Health, United States]

    Request for Information: Scientific and Regulatory Issues to be Explored at an Upcoming Pluripotent Stem Cell Workshop Involving NIH and FDA (NOT-NS-10-016) [National Institutes of Health, United States]

    Drug Safety and Risk Management Advisory Committee; Notice of Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

    Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of Patient Information Prototypes (Docket No. FDA-2010-N-0184) [Food and Drug Administration, United States]

    EVENTS

    Stem Cells, Tissue Homeostasis and Cancer Conference
    May 12-15, 2010
    Heidelberg, Germany

    16th International Society for Cellular Therapy (ISCT) Meeting
    May 23-26, 2010
    Philadelphia, United States

    Systems Biology of Stem Cells
    May 24-25, 2010
    Irvine, United States

    International Symposium, Stem Cells in Biology and Disease
    May 26-28, 2010
    Lisbon, Portugal

    International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
    June 16-19, 2010
    San Francisco, United States

    XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
    June 26-July 1, 2010
    Berlin, Germany

    The European Molecular Biology Organization (EMBO) Meeting 2010
    September 4-7, 2010
    Barcelona, Spain

    Stem Cells USA & Regenerative Medicine Congress 2010
    September 13-15, 2010
    Philadelphia, United States

    Society for Hematology and Stem Cells (ISEH) 2010 Meeting
    September 15-18, 2010
    Melbourne, Australia

    Stem Cells and Regeneration
    October 3-9, 2010
    Woods Hole, United States

    American Association of Blood Banks (AABB) Annual Meeting 2010
    October 9-12, 2010
    Baltimore, United States

    Fraunhofer Life Science Symposium Leipzig 2010
    October 29-30, 2010
    Leipzig, Germany

    52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    December 4-7, 2010
    Orlando, United States

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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