CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Direct Conversion of Human Fibroblasts to Multilineage Blood Progenitors Here, researchers demonstrate the ability to generate progenitors and mature cells of the hematopoietic fate directly from human dermal fibroblasts without establishing pluripotency. [Nature] Murine Erythroid Short-Term Radioprotection Requires a BMP4-Dependent, Self-Renewing Population of Stress Erythroid Progenitors In this study, researchers found that the bone morphogenetic protein 4-dependent (BMP4-dependent) stress erythropoiesis pathway was required and specific for erythroid short-term radioprotection following bone marrow transplantation. [J Clin Invest] Vitamin D Insufficiency and Prognosis in Chronic Lymphocytic Leukemia (CLL) Researchers evaluated the relationship of 25(OH)D serum levels with time-to-treatment and overall survival in newly diagnosed CLL patients participating in a prospective cohort study(discovery cohort) and a separate cohort of previously untreated patients participating in an observational study(confirmation cohort). [Blood] NK-Cell Education is Shaped by Donor HLA Genotype After Unrelated Allogeneic Hematopoietic Stem-Cell Transplantation The rules governing natural killer (NK)-cell-education in the allogeneic environment created by unrelated hematopoietic stem-cell transplantation are still largely elusive, especially in an unrelated donor setting. The data suggest that the NK cell’s education partner could be of hematopoietic rather than extra-hematopoietic origin. [Blood] Chemotherapy Resistance in Acute Lymphoblastic Leukemia Requires hERG1 Channels and Is Overcome by hERG1 Blockers Bone marrow mesenchymal cells can protect leukemic cells from chemotherapy, thus increasing their survival rate. Researchers studied the potential molecular mechanisms underlying this effect in acute lymphoblastic leukemia cells. [Blood] Regulation of Hematopoietic Cell Clusters in the Placental Niche Through SCF/Kit Signaling in Embryonic Mouse Hematopoietic stem cells (HSCs) emerge from and expand in the mouse placenta at mid-gestation. To determine their compartment of origin and define extrinsic signals governing their commitment to this lineage, researchers identified hematopoietic cell clusters in mouse placenta, defined as cells expressing the embryonic HSC markers CD31, CD34 and Kit, by immunohistochemistry. [Development] Anti-Inflammatory Cytokines Hepatocyte Growth Factor and Interleukin-11 are Over-Expressed in Polycythemia Vera and Contribute to the Growth of Clonal Erythroblasts Independently of JAK2V617F In the present study, researchers provide evidence that inflammation-linked cytokines are required for the growth of JAK2V617F-mutated erythroid progenitors. [Oncogene] A DNA-Binding Mutant of TAL1 Cooperates with LMO2 to Cause T Cell Leukemia in Mice The data demonstrate that the DNA-binding activity of Tal1 is not required to cooperate with Lmo2 to cause leukemia in mice and suggest that Lmo2 may cooperate with Tal1 to interfere with E47/HEB function(s). [Oncogene] Epigenetics: Prenatal Exposure to Genistein Leaves a Permanent Signature on the Hematopoietic Lineage Researchers studied hematopoiesis of mice prenatally exposed to genistein (270 mg/kg feed) compared with that of mice prenatally exposed to phytoestrogen-poor feed and observed a significant increase in granulopoiesis, erythropoiesis, and mild macrocytosis at the adult age of 12 weeks. [FASEB J] CLINICAL RESEARCH Alemtuzumab Treatment of Intermediate-1 Myelodysplasia Patients Is Associated With Sustained Improvement in Blood Counts and Cytogenetic Remissions Researchers conducted a nonrandomized, off-label, pilot, phase I/II study of alemtuzumab monotherapy in patients with myelodysplastic syndromes who were judged likely to respond to immunosuppressive therapy based on the following criteria: HLA-DR15-negative patients whose age plus the number of months of RBC transfusion dependence (RCTD) was less than 58; and HLA-DR15-positive patients whose age plus RCTD was less than 72. [J Clin Oncol] A Phase II Study of High Dose Lenalidomide as Initial Therapy for Older Patients with Acute Myeloid Leukemia (AML) Researchers evaluated the efficacy of lenalidomide as front-line therapy for older AML patients. [Blood]
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EVENTS (Listed by Date) 22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics November 16-19, 2010 Berlin, Germany 9th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases November 17-19, 2010 Sonoma, United States 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States 5th Annual Stem Cell Meeting on the Mesa December 7, 2010 La Jolla, United States Highlights of American Society of Hematology (ASH) Vancouver January 21-22, 2011 Vancouver, Canada Highlights of American Society of Hematology (ASH) Washington, D.C. January 28-29, 2011 Washington, D.C., United States Highlights of American Society of Hematology (ASH) San Francisco January 28-29, 2011 San Francisco, United States Highlights of American Society of Hematology (ASH) New York February 4-5, 2011 New York, United States Highlights of American Society of Hematology (ASH) San Diego February 4-5, 2011 San Diego, United States BMT Tandem Meetings (ASBMT/CIBMTR) February 17-21, 2011 Honolulu, Hawaii Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment February 23-25, 2011 San Francisco, United States American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada Keystone Symposia: Hematopoiesis March 27-April 1, 2011 Big Sky, United States United Kingdom National Stem Cell Network 2011 Annual Scientific Conference March 30-April 1, 2011 York, United Kingdom American Association for Cancer Research (AACR) 102nd Annual Meeting 2011 April 2-6, 2011 Orlando, United States 37th Annual Meeting of the European Group for Blood and Marrow Transplantation April 3-6, 2011 Paris, France International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies) Lab Technologist – Tissue Culture (STEMCELL Technologies) Product Manager – Pluripotent Stem Cells (STEMCELL Technologies) Business Manager – Centre for Blood Cell Therapies (Cell Therapies) Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News at no cost. Visit here to post your career opportunities.
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