SCIENCE NEWS
Tiny RNA Shown to Cause Multiple Types of Leukemia
Whitehead Institute researchers have shown in mouse models that overexpression of the microRNA 125b (miR-125b) can independently cause leukemia and accelerate the disease’s progression. [Press release from the Whitehead Institute for Biomedical Research discussing online prepublication in the Proceedings of the National Academy of Sciences USA]
Study Identifies Potential Mechanism of Drug Resistance of CLL in Bone Marrow and Lymph Nodes
Investigators offer a new explanation of why chronic lymphocytic leukemia (CLL) tends to recur in the lymph nodes and bone marrow after being cleared from the bloodstream by chemotherapy. [Press release from the Dana-Farber Cancer Institute discussing data presented at the 52nd Annual Meeting of the American Society of Hematology (ASH)]
Phase I Trial Indicates Ponatinib May Thwart Most Resistant CML
A new drug appears to help chronic myeloid leukemia (CML) patients who are out of treatment options after first- and second-line drugs have failed them or because their cancer cells have a mutation that makes them resistant from the start, researchers reported. [Press release from the MD Anderson Cancer Center discussing data presented at the 52nd Annual Meeting of the American Society of Hematology (ASH)]
First Results from Phase II Study of Fractionated Radioimmunotherapy with Y-90 Epratuzumab in Aggressive Lymphoma Presented at Hematology Conference
Immunomedics, Inc., reported that consolidation treatment with fractionated yttrium-90 (Y-90) labeled epratuzumab, after induction therapy with rituximab and CHOP chemotherapy, improved remission status of adult patients with diffuse large B cell lymphoma, a form of aggressive lymphoma. [Press release from Immunomedics, Inc. discussing data presented at the 52nd Annual Meeting of the American Society of Hematology (ASH)]
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LABORATORY RESEARCH
Allogeneic Effector/Memory Th-1 Cells Impair FoxP3+ Regulatory T Lymphocytes and Synergize with Chaperone-Rich Cell Lysate Vaccine to Treat Leukemia
Here, researchers demonstrate that effector/memory CD4+ T helper-1 (Th-1) lymphocytes, in addition to polarizing type-1 anti-tumor immune responses, impair tumor-induced CD4+CD25+FoxP3+ regulatory T cell immunosuppressive function in vitro and in vivo. [Blood]
MicroRNA-125b Expands Hematopoietic Stem Cells and Enriches for the Lymphoid-Balanced and Lymphoid-Biased Subsets
Here, researchers show that microRNA-125b (miR-125b) is highly expressed in hematopoietic stem cells and its expression decreases in committed progenitors. [Proc Natl Acad Sci USA]
As4S4 Targets RING-Type E3 Ligase c-CBL to Induce Degradation of BCR-ABL in Chronic Myelogenous Leukemia
Arsenic, a curative agent for acute promyelocytic leukemia, induces cell apoptosis and degradation of BCR-ABL in chronic myelogenous leukemia (CML). Researchers demonstrated that ubiquitination and degradation of BCR-ABL was mediated by c-CBL, a RING-type E3 ligase that was also shown to be involved in ubiquitination for many other receptor/protein tyrosine kinases. [Proc Natl Acad Sci USA]
MicroRNA miR-125b Causes Leukemia
Researchers show that overexpression of miR-125b is sufficient both to shorten the latency of BCR-ABL-induced leukemia and to independently induce leukemia in a mouse model. [Proc Natl Acad Sci USA]
BCR/ABL Stimulates WRN to Promote Survival and Genomic Instability
In summary, researchers postulate that BCR/ABL-mediated stimulation of WRN modulates the efficiency and fidelity of major DNA double-strand break repair mechanisms to protect leukemia cells from apoptosis and to facilitate genomic instability. [Cancer Res]
CLINICAL RESEARCH
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate production. Mutational and epigenetic profiling of a large acute myeloid leukemia (AML) patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and a specific hypermethylation signature. [Cancer Cell]
HLA-Matched Sibling Bone Marrow Transplantation for Beta-Thalassemia Major
Researchers describe outcomes after HLA-matched sibling bone marrow transplantation (BMT) for 179 patients with beta-thalassemia major. [Blood]
Rituximab-Cyclophosphamide-Dexamethasone Combination in the Management of Autoimmune Cytopenias Associated with Chronic Lymphocytic Leukemia
Researchers report their experience on rituximab-cyclophosphamide-dexamethasone (RCD) combination therapy for the treatment of autoimmune disorders (AIDs) in 48 chronic lymphocytic leukemia (CLL) patients. [Leukemia]
Inhibition of STAT5 by the Inhibitor of Janus Kinases Stimulates Dormant Human Leukemia CD34+/CD38- Cells and Sensitizes Them to Anti-Leukemia Agents
To verify molecular mechanisms by which leukemia stem cells (LSCs) maintain a dormant state, researchers explored the activity of the major pro-survival signal pathways in CD34+/CD38- compartment, supposed to contain LSCs, and CD34+/CD38+ counterparts from patients with acute myelogenous leukemia (AML, n=11) by fluorescence-activated cell sorting. [Int J Cancer]
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EVENTS (Listed by Date)
The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China
Highlights of American Society of Hematology (ASH) Vancouver
January 21-22, 2011
Vancouver, Canada
Highlights of American Society of Hematology (ASH) Washington, D.C.
January 28-29, 2011
Washington, D.C., United States
Highlights of American Society of Hematology (ASH) San Francisco
January 28-29, 2011
San Francisco, United States
Highlights of American Society of Hematology (ASH) New York
February 4-5, 2011
New York, United States
Highlights of American Society of Hematology (ASH) San Diego
February 4-5, 2011
San Diego, United States
BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii
Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment
February 23-25, 2011
San Francisco, United States
Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany
American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada
PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States
Keystone Symposia: Hematopoiesis
March 27-April 1, 2011
Big Sky, United States
United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom
American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States
37th Annual Meeting of the European Group for Blood and Marrow Transplantation
April 3-6, 2011
Paris, France
World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom
International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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