Hematopoiesis News Volume 11.08 | Mar 3 2020

TOP STORY

Mount Sinai Researchers Discover New Approach for Use of Stem Cells to Improve Bone Marrow Transplantation

Researchers report that manipulation of metabolic activity around lysosomes, the storage and recycling centers within cells, can increase by more than 90-fold the potency of blood-forming stem cells in bone marrow transplantation. [Press release from Mount Sinai discussing online prepublication in Cell Stem Cell] Press Release | Abstract

(Ranked by impact factor of the journal)

TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis

Expression of TRAF-interacting protein with a forkhead-associated domain B (TIFAB) in hematopoietic stem/progenitor cells permitted ubiquitin-specific peptidase 15 (USP15) signaling to substrates, including MDM2 and KEAP1, and mitigated p53 expression. [Cell Rep] Abstract | Graphical Abstract

ZBTB7A Prevents RUNX1-RUNX1T1-Dependent Clonal Expansion of Human Hematopoietic Stem and Progenitor Cells

Scientists investigated the role of ZBTB7A and its mutations in the context of normal and malignant hematopoiesis. They demonstrated that clinically relevant ZBTB7A mutations in acute myeloid leukemia t(8;21) led to loss of function and resulted in perturbed myeloid differentiation with block of the granulocytic lineage in favor of monocytic commitment. [Oncogene] Full Article

Thrombopoietin Enhances Hematopoietic Stem and Progenitor Cell Homing by Impeding Matrix Metalloproteinase 9 Expression

Researchers report a novel function of recombinant human thrombopoietin in increasing hematopoietic stem and progenitor cell homing to the bone marrow. [Stem Cells Transl Med] Full Article

Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway

The authors found that hypercholesterolemia downregulated Ten eleven translocation 1 (Tet1) in HSCs. The total HSC population was increased, while the long-term population, side population and reconstitution capacity of HSCs were significantly decreased in Tet1^−/− mice. [Sci Rep] Full Article

The Lysine Methyltransferase SMYD2 Is Required for Normal Lymphocyte Development and Survival of Hematopoietic Leukemias

Investigators showed that conditional SET and MYND domain-containing lysine methyltransferase (SMYD)2 loss disrupted hematopoiesis at and downstream of the HSC via both apoptotic loss and transcriptional deregulation of HSC proliferation and disruption of Wnt-β-catenin signaling. [Genes Immun] Abstract

Autologous CXCR4⁺ Hematopoietic Stem Cells Injected into the Scar Tissue of Chronic Myocardial Infarction Patients Normalizes Tissue Contractility and Perfusion

Researchers determined if autologous CXCR4 stem cells could restore damaged myocardial tissue in patients with chronic myocardial infarction lesions. [Arch Med Res] Abstract

Cellular and Molecular Architecture of Hematopoietic Stem Cells and Progenitors in Genetic Models of Bone Marrow Failure

Using deep phenotypic analysis of early progenitors in Fanconi anemia/Shwachman-Diamond syndrome bone marrow samples, investigators revealed selective survival of progenitors that phenotypically resembled granulocyte-monocyte progenitors. [JCI Insight] Full Article

CLINICAL RESEARCH

Inferior Outcome of Allogeneic Stem Cell Transplantation for Secondary Acute Myeloid Leukemia in First Complete Remission as Compared to De Novo Acute Myeloid Leukemia

To define the outcome of secondary acute myeloid leukemia (sAML) in the context of allogeneic stem cell transplantation, a retrospective, registry-based comparison was performed, including 11,439 patients with de novo and 1325 with sAML. [Blood Cancer J] Abstract

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Vitamin D and Hematopoiesis

Scientists examine the influences of active vitamin D on ‘developmental’ hematopoiesis and the immune cells produced. [Curr Tissue Microenv Rep] Abstract

EZH2 Function in Immune Cell Development

The authors review the current state of understanding of the roles for EZH2, and polycomb repressive complex 2 more generally, in the development and function of the immune system. [Biol Chem] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Merck’s KEYTRUDA^® (Pembrolizumab) Significantly Improved Progression-Free Survival Compared with Brentuximab Vedotin in Patients with Relapsed or Refractory Classical Hodgkin Lymphoma (cHL)

Merck announced that the Phase III KEYNOTE-204 trial evaluating KEYTRUDA, Merck’s anti-PD-1 therapy, for the treatment of adult patients with relapsed or refractory cHL met one of its dual primary endpoints of progression-free survival. [Merck & Co., Inc.] Press Release

SELLAS Announces Positive Follow-Up Phase I/II Clinical Data for Galinpepimut-S (GPS) in Acute Myeloid Leukemia (AML)

SELLAS Life Sciences Group, Inc. announced final follow-up data for its Phase I/II study of GPS in patients with AML in second complete remission. [SELLAS Life Sciences Group, Inc.] Press Release

Actinium Announces Actimab-A Plus 7+3 Combination Trial for Newly Diagnosed Acute Myeloid Leukemia Patients

Actinium Pharmaceuticals, Inc. announced that it is expanding its CD33 program studying Actimab-A into a combination trial with the chemotherapy regimen 7+3 in patients with newly diagnosed acute myeloid leukemia who have intermediate or high-risk cytogenetic or molecular markers. [Actinium Pharmaceuticals, Inc.] Press Release

China Bans Cash Rewards for Publishing Papers

Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial

UC Santa Cruz Fires Graduate Students Taking Part in Strike

The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist] Editorial

NEW International Symposium on Technical Innovations in Laboratory Hematology
May 21-23, 2020
Melbourne, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Pediatric Oncology (Universitätsklinikum Carl Gustav Carus)

Research Associate – Stem Cell and Gene Therapy Program (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – RNA Modifications, Hematopoiesis and Cancer (Lund University)

Assistant/Associate Professor – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Plasma Cell Development and Functional Heterogeneity (Western Michigan University)

Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Children’s Hospital)

Postdoctoral Researcher – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation)

Postdoctoral Fellow – Hereditary and Childhood Tumors (The University of British Columbia)

Postdoctoral Fellowship – Personalized Cancer Treatments (MGH Cancer Center)

Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine)

Associate/Professor – Hematology & Oncology (UC Davis School of Medicine)

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