Hematopoiesis News Volume 11.19 | May 19 2020

TOP STORY

Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

Investigators showed that expression of N⁶-methyladenosine demethylase ALKBH5 was regulated by chromatin state alteration during leukemogenesis of human acute myeloid leukemia (AML), and ALKBH5 was required for maintaining leukemia stem cell function but was dispensable for normal hematopoiesis. [Cell Stem Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

Researchers showed integrin-linked kinase, a key constituent of focal adhesions, was highly expressed in tyrosine kinase inhibitor-nonresponsive patient cells and their leukemic stem cells. [Cell Stem Cell] Full Article | Graphical Abstract

Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells

The authors used iterations of index-sorting of Gata2-expressing intra-aortic hematopoietic cluster cells, single-cell transcriptomics, and functional analyses to connect HSC identity to specific gene expression. [Cell Rep] Full Article | Graphical Abstract

Nutrient-Driven O-GlcNAcylation Controls DNA Damage Repair Signaling and Stem/Progenitor Cell Homeostasis

Scientists showed that hyper-O-GlcNacylation led to elevated insulin signaling, hyperproliferation, and DNA damage response activation that mimicked the glucose- and oxidative-stress-induced response. [Cell Rep] Full Article | Graphical Abstract

Tropomyosin 1 Genetically Constrains In Vitro Hematopoiesis

CRISPR/Cas9-mediated TPM1 knockout in human induced pluripotent stem cells enhanced hematopoietic progenitor development, increasing total megakaryocyte and erythroid cell yields. [BMC Biol] Full Article

A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation Is Involved in Homing and Engraftment of Hematopoietic Stem Progenitor Cells (HSPCs)

The authors provide evidence that the MBL pathway was involved in activation of complement cascade in myeloablated transplant recipient bone marrow and thus played an important role in homing and engraftment of HSPCs. [Stem Cell Rev Rep] Full Article

Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects

Investigators showed that aging-associated decreased expression of CXCR4 expression on bone marrow mesenchymal stem cells played a crucial role in the development of the hematopoietic stem and progenitor cells aging phenotype. [Stem Cell Rev Rep] Abstract

CLINICAL RESEARCH

Blood Transfusion Support for Sickle Cell Patients during Hematopoietic Stem Cell Transplantation: A Single‐Institution Experience

Scientists evaluated the impact of anti‐erythrocyte antibodies and ABO mismatch on overall survival and on transfusion requirements until days 30 and 180 from transplantation. [Br J Haematol] Abstract

Outcome of Stem Cell Transplantation for Waldenström’s Macroglobulinemia: Analysis of the Japan Society for Hematopoietic Cell Transplantation (JSHCT) Lymphoma Working Group

Researchers retrospectively evaluated the outcome of autologous and allogeneic stem cell transplantation (SCT) for patients with Waldenström’s macroglobulinemia using the registry database of the Japan Society for Hematopoietic Cell Transplantation. Forty-six patients receiving autologous and 31 receiving allogeneic SCT were analyzed. [Ann Hematol] Abstract

Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News.

A Sticky Wicket: Defining Molecular Functions for CD34 in Hematopoietic Cells

The authors highlight some of the more well-defined functions of CD34 in hematopoietic stem and progenitor cells with a focus on proposed functions most relevant to hematopoietic stem cell transplant biology. [Exp Hematol] Abstract | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Tolero Pharmaceuticals Announces Expansion of the Zella 102 Study in Patients with Intermediate and High-Risk Myelodysplastic Syndromes (MDS)

Tolero Pharmaceuticals, Inc. announced that the first patient has been dosed with a one-hour dosing schedule for investigational agent alvocidib, a potent CDK9 inhibitor, administered in sequence after azacitidine, in the expansion of the Phase Ib/II Zella 102 study in patients with MDS. [Tolero Pharmaceuticals, Inc.] Press Release

Seattle Genetics Announces ADCETRIS^® (Brentuximab Vedotin) Receives European Commission Approval for Treatment of Adult Patients with Previously Untreated Systemic Anaplastic Large Cell Lymphoma

Seattle Genetics, Inc. announced that its collaborator, Takeda Pharmaceutical Company Limited, received approval from the European Commission to extend the current conditional marketing authorization for ADCETRIS^® to include treatment of adult patients with previously untreated systemic anaplastic large cell lymphoma, in combination with CHP (cyclophosphamide, doxorubicin, prednisone). [Seattle Genetics, Inc.] Press Release

Open-Access Science Funders Announce Price Transparency Rules for Publishers

Science journals will have to disclose the costs of publishing articles in order for them to be paid for by a coalition of research funders pushing for open access. [ScienceInsider] Editorial

Publishers Launch Joint Effort to Tackle Altered Images in Research Papers

The world’s largest science publishers are teaming up to discuss how to automatically flag altered or duplicated images in research papers. A new working group – the first formal cross-industry initiative to discuss the issue – aims to set standards for software that screens papers for problematic images during peer review. [Nature News] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

We are suspending new event postings in our newsletters and on Twitter.
We will strive to keep our current event listings updated with event status.
We encourage you to visit event sites directly for updates.

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Research Fellow – Hematologic Malignancy (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital)

Postdoctoral Position – Tumor Immunology (University of Maryland)

Postdoctoral Position – Leukemia (Josep Carreras Leukaemia Research Institute)

Postdoctoral Position – Immunology/Molecular Biology (NIH National Heart, Lung, and Blood Institute)

Postdoctoral Associate – Hematopoiesis (The Jackson Laboratory)

PhD Position – Leukemic Stem Cells and Metabolism (University of Bern)

Postdoctoral Fellow – Hematopoiesis Research (Harvard Medical School)

Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine)

Associate/Professor – Hematology & Oncology (UC Davis School of Medicine)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Hematopoiesis News? Click here to submit!

Comments or suggestions? Submit your feedback here.