| Vol. 11.24 – 23 June, 2020 |
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| Scientists used single-cell RNA sequencing to interrogate the rare CD34+ progenitor and the more differentiated CD34– fractions in the human postnatal thymus. [Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that loss of diaphanous-related formin mDia2 led to impaired engraftment of long-term hematopoietic stem cells and loss of competitive hematopoietic stem and progenitor cell repopulation. [Nature Communications] |
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| The authors isolated a mouse strain with a single missense mutation, MlklD139V, that altered the two-helix ‘brace’ that connects the killer four-helix bundle and regulatory pseudokinase domains. [Nature Communications] |
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| Researchers tested 129 FDA-approved anticancer drugs in a tet2-deficient zebrafish model and showed that topoisomerase 1 (TOP1)-targeted drugs and PARP1 inhibitors selectively killed tet2-mutant HSPCs. [Leukemia] |
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| Scientists showed that S100A6 regulated intracellular and mitochondria calcium buffering of HSC upon cytokine stimulation and demonstrated that Akt activator SC79 reverted the levels of intracellular and mitochondrial calcium in HSC. [Leukemia] |
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| Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases. [Oncogene] |
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| Researchers demonstrated that collecting and processing of human cord blood at 4°C within minutes of the baby’s birth results in significantly enhanced numbers of rigorously defined phenotypic hematopoietic stem cell and self‐renewing NSG immune‐deficient mouse engrafting and SCID‐repopulating cells. [Stem Cells] |
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| By using mass spectrometry combined with RNA sequencing, scientists showed that absence of P2y12 induced excessive erythropoiesis, evidenced by significantly increased expression of mature erythrocytes marker α-globin, β-globin. [Acta Pharmacologica Sinica] |
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| To model the natural HSC niche in vitro, researchers optimized the HSC medium composition with a panel of cytokines and valproic acid and used an artificial 3D bone marrow-like scaffold made of polydimethylsiloxane. [PLoS One] |
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| | In order to explore the possibility of HLA-mismatched hematopoietic stem cell transplantation from family donors beyond haploidentical relatives, investigators conducted a prospective Phase I/II study of 2-HLA-haplotype-mismatched hematopoietic stem cell transplantation. [Bone Marrow Transplantation] |
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| The authors examine aspects of Mixed Lineage Leukemia Translocated to, 10 (MLLT10), contextualizing its function in benign and malignant hematopoiesis. [Experimental Hematology] |
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| Marker Therapeutics, Inc. announced that the United States Adopted Names Council has approved “zelenoleucel” as the nonproprietary name for MT-401, a multi-tumor-associated antigen-specific T cell product candidate for the treatment of patients with acute myeloid leukemia following allogeneic stem cell transplant in both adjuvant and active disease settings. [Marker Therapeutics, Inc.] |
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| AbbVie announced that the FDA will review a supplemental New Drug Application for IMBRUVICA® in combination with rituximab for the treatment of WM, a rare and incurable type of non-Hodgkin’s lymphoma. [AbbVie Inc.] |
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| With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science. [Nature News] |
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| 2020-10-02 – 2020-10-05 Boston, Massachusetts, United States |
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| Lund University – Lund, Sweden |
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| Columbia University – New York, New York, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| Karolinska Institutet – Huddinge, Sweden |
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| University of Bristol – Bristol, United Kingdom |
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