 | | Vol. 11.29 – 28 July, 2020 |
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| The authors analyzed the BLUEPRINT consortium RNA- seq data for mature hematopoietic cell types. The data comprised 90 total RNA-seq samples, each composed of one of 27 cell types, and 32 small RNA-seq samples, each composed of one of 11 cell types.
[Haematologica] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that the nuclear speckle-specific long noncoding RNA MALAT1 controlled chimeric mRNA export processes and regulated myeloid progenitor cell differentiation in malignant hematopoiesis.
[Cell Death & Disease] |
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| Investigators found that Ryk—an atypical Wnt receptor with a pseudokinase domain—had a Wnt-modulating effect in bone marrow stromal cells to control hematopoiesis-supporting activities.
[Experimental and Molecular Medicine] |
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| In this single-center retrospective study, researchers analyzed the utilization of hematopoietic progenitor cells (HPCs) collected and stored at the time of first autologous hematopoietic cell transplantation in patients with myeloma and the cost implications of HPC collection targets sufficient for two transplants.
[Biology of Blood and Marrow Transplantation] |
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| Researchers demonstrated by Monte Carlo modeling that two mechanisms could underlie an aneuploidy peak: rapid expansion of the engrafted hematopoietic stem and progenitor cell population and bone marrow microenvironment degradation caused by pre-transplantation radiation treatment.
[Scientific Reports] |
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| To improve predictive understanding of drug-induced myelosuppression, scientists developed a quantitative systems pharmacology model of hematopoiesis in vitro for quantifying the effects of anti-cancer agents on multiple hematopoietic cell lineages.
[PLoS Computational Biology] |
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| Investigators analyzed bone marrow and found that gemfibrozil reduced erythrocytes and hematopoietic stem cells in wild-type mice but not in PPAR-alpha-knockout mice, while increased colony-forming units were observed only in wild-type mice treated with gemfibrozil.
[International Journal of Molecular Sciences] |
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| C57BL/6 mice were randomly divided into two groups: a control group and a hindlimb suspension group. After four weeks of hindlimb suspension, scientists found that this simulated microgravity condition increased the percentage of monocytes and macrophages and decreased the percentage of B lymphocytes and mature red cells in bone marrow.
[Cell Biology International] |
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| Researchers analyzed newly diagnosed multiple myeloma patients with del(17p) and/or t(4;14) undergoing either upfront single autologous, tandem autologous or tandem autologous/reduced-intensity allogeneic stem cell transplantation.
[Bone Marrow Transplantation] |
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| To improve disease control without increasing the toxicity of a reduced-intensity allogeneic hematopoietic cell transplantation in multiple myeloma, a Phase I trial was performed using an antibody-radionuclide conjugate targeting CD45 as conditioning.
[Bone Marrow Transplantation] |
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| Researchers highlight how mitochondrial metabolism determines hematopoietic stem cell (HSC) fate, and focus on the links between mitochondria, endoplasmic reticulum, and lysosomes in HSC metabolism.
[Developmental Cell] |
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| The authors summarize the current understanding of the importance of clonal hematopoiesis as a new causal risk factor for atherosclerotic cardiovascular disease and heart failure.
[Journal of Internal Medicine] |
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| Ascentage Pharma announced that the Phase Ib study of the company’s novel MDM2-p53 inhibitor candidate APG-115 as a single agent or in combinations for the treatment of Chinese patients with relapsed/refractory acute myeloid leukemia, or relapsed/progressed high/very high risk myelodysplastic syndrome has dosed its first patient in China.
[Ascentage Pharma] |
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| ElsaLys Biotech announced the FDA agreement to start the LEUKOTAC® submission process for a Biologics License Application for the treatment of steroid-refractory acute graft-versus-host disease, grade II-IV adult patients.
[ElsaLys Biotech SA] |
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| August 19 – August 21
Virtual |
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| | The Francis Crick Institute – London, United Kingdom |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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| | Lund University – Lund, Sweden |
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| | Columbia University – New York, New York, United States |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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