 | | Vol. 11.36 – 15 September, 2020 |
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| Scientists explored the role of BCL6 in acute myeloid leukemia (AML). BCL6 was expressed at variable and often high levels in AML cell lines and primary AML samples.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Analysis revealed that hematopoietic stem/progenitor cell numbers were significantly reduced in the bone marrow compared to wild-type littermates. Moreover, g-aminobutyric acid type B receptor subunit 1 null hematopoietic stem cells had diminished capacity to reconstitute irradiated recipients in a competitive transplantation model.
[Blood] |
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| Researchers evaluated autologous engraftment and fetal hemoglobin induction potential of erythroid-specific BCL11A enhancer edited hematopoietic stem and progenitor cells in four non-human primates.
[Journal of Clinical Investigation] |
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| Scientists showed that colony-stimulating factor 1 receptor (CSF1R) inhibition by PLX5622 affected the myeloid and lymphoid compartments, caused long-term changes in bone marrow-derived macrophages by suppressing interleukin 1β, CD68, and phagocytosis but not CD208, following exposure to endotoxin, and also reduced the population of resident and interstitial macrophages of peritoneum, lung, and liver but not spleen.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators generated a HDAd5/35++ adenovirus vector containing both modules and tested it in vitro and after in vivo hematopoietic stem cell/progenitor transduction in “healthy” CD46/β-YAC mice and in a sickle cell disease mouse model.
[Molecular Therapy] |
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| The authors established induced pluripotent stem cells from patients with Shwachman-Diamond syndrome and analyzed their in vitro hematopoietic and endothelial differentiation potentials.
[Scientific Reports] |
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| This study involved flowcytometric protein expression analysis of insulin growth factor receptor, PI3K‐Akt‐mTOR pathway, the autophagy related proteins, the status of antioxidative molecules SOD2 and SDF1 and apoptosis profiling in ethyl‐nitroso‐urea induced myelodysplasia.
[Environmental Toxicology] |
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| Researchers histologically examined 3- to 6-month-old NSG mice, naïve or engrafted with CD34+ human hemopoietic stem cells, and employed a quantitative immunohistochemical approach to identify human and murine cell compartments, comparing the results with the fluorescent activated cell sorting data.
[Veterinary Pathology] |
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| Scientists quantified the magnitude, domains and duration of change in health‐related quality of life in patients with systemic sclerosis (SSc) treated with autologous hematopoietic stem cell transplantation (AHSCT) compared to similar SSc patients who did not undergo AHSCT.
[Arthritis & Rheumatology] |
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| Investigators discuss genetic models of mouse dendritic cells (DCs) development and function that have aided in correlating ontogeny with function, as well as how these findings can be translated to human DCs and their progenitors.
[Nature Reviews Immunology] |
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| The authors summarize the role of all-trans retinoic acid in normal hematopoiesis and in acute myeloid leukemia (AML), focusing on its impact on AML stem cells.
[Cell Cycle] |
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| Cullinan Oncology, LLC, the German Cancer Research Center and the Eberhard Karls University of Tübingen, Faculty of Medicine announced the formation of Cullinan Florentine, a company focused on developing a novel FLT3 x CD3 bispecific antibody for the treatment of patients with acute myeloid leukemia (AML).
[Cullinan Oncology, LLC] |
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| Gilead Sciences, Inc. announced that the FDA has granted Breakthrough Therapy designation for magrolimab, a first-in-class, investigational anti-CD47 monoclonal antibody for the treatment of newly diagnosed myelodysplastic syndrome.
[Gilead Sciences, Inc.] |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | University of York – Heslington Campus – York, United Kingdom |
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| | Princeton University – Princeton, New Jersey, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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