 | | Vol. 12.10 – 23 March, 2021 |
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| Scientists created Dnmt3a-mosaic mice by transplanting Dnmt3a−/− and WT HSCs into WT mice and observed the substantial expansion of Dnmt3a−/− HSCs during chronic mycobacterial infection.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Genetic attenuation or pharmacological inhibition of VLCAD hindered mitochondrial respiration and fatty acid oxidation contribution to the TCA cycle, resulting in decreased viability, proliferation, clonogenic growth and acute myeloid leukemia cell engraftment.
[Blood] |
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| Interferon gamma was required for increased expression of the chemokine receptor CCR5 on dysfunctional macrophage. CCR5 antagonism in murine severe aplastic anemia improved survival, correlating with increased platelets and significantly increased platelet-biased CD41hi HSCs.
[Leukemia] |
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| Researchers characterized a hematopoiesis defective zebrafish mutant line named smu07, which was obtained from our previous forward genetic screening, and found the hematopoietic stem and progenitor cell expansion deficiency in the mutant.
[Science China Life Sciences] |
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| To characterize the dynamics following different types of perturbations, the authors investigated a model representing hematopoiesis as a sequence of compartments covering all maturation stages – from stem to mature cells – where feedback regulated cell production to ongoing necessities.
[iScience] |
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| Investigators showed that polyphenol-rich sugarcane extract exerted anti-cancer properties on a range of cancer cells including human and mouse colon cancer cells lines; human lung cancer, human ovarian cancer, pro-monocytic human leukemia and mouse melanoma cell lines
[PLoS One] |
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| Linc00402 was increased in donor T cells from patients who underwent allogeneic cardiac transplantation and in murine T cells.
[Science Translational Medicine] |
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| Scientists analyzed the frequency, clinical significance, and prognostic relevance of RAS pathway alterations in 328 pediatric patients with de novo acute myeloid leukemia.
[Haematologica] |
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| A Phase II study of acalabrutinib was conducted in patients with relapsed/refractory chronic lymphocytic leukemia who were ibrutinib-intolerant and had continued disease activity.
[Haematologica] |
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| The Acute Leukemia Working Party/European Society for Blood and Marrow Transplantation registry was used to evaluate the outcomes of adult patients with acute lymphoblastic leukemia who underwent hematopoietic cell transplantation during 2011 through 2015 and compared them with the outcomes of those who underwent transplantation during 2016 through 2018.
[Cancer] |
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| Targeted therapy has markedly improved outcomes for pediatric chronic myelogenous leukemia, while raising a number of clinical questions, including the possibility of treatment-free remission and long-term health implications of prolonged tyrosine kinase inhibitors exposure at a young age.
[Current Oncology Reports] |
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| The authors review recent proteomic studies that have furthered our understanding of erythropoiesis with a focus on quantitative mass spectrometry approaches to measure the abundance of transcription factors and cofactors during differentiation.
[Current Opinion in Hematology] |
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| Sangamo Therapeutics, Inc. announced that the European Medicines Agency’s Committee for Orphan Medicinal Products released details supporting the Orphan Designation of BIVV003, an investigational ex vivo gene-edited cell therapy product candidate currently being evaluated for the treatment of sickle cell disease in the Phase I/II PRECIZN-1 study partnered with Sanofi.
[Sangamo Therapeutics, Inc.] |
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| The American Society of Hematology announced the names of 19 talented early-career investigators who will receive critical funding to support their resumption of research that was paused amid pandemic-related shutdowns and uncertainty.
[Amercian Society of Hematology] |
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| November 29 – December 1, 2021
Barcelona, Spain |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | City of Hope – Los Angeles, California, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
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