 | | Vol. 12.11 – 30 March, 2021 |
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| Administration of annexin A1 mimetic peptide AnxA1Ac2-26 ameliorated cerebral thrombotic responses in sickle transgenic mice via regulation of the FPR2/ALX pathway.
[Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that YBX1 was specifically required for maintaining myeloid leukemia cell survival in an m6A-dependent manner.
[Blood] |
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| Scientists showed that the activation of HOXBLINC, a HOXB locus-associated long non-coding RNA, was a critical downstream mediator of NPM1c+-associated leukemic transcription program and leukemogenesis.
[Nature Communications] |
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| Through deep coverage of the cellular proteome of fetal and adult lympho-myeloid multipotent progenitors, common lymphoid progenitors, and granulocyte-monocyte progenitors, researchers established that features traditionally attributed to adult hematopoiesis were conserved across lymphoid and myeloid lineages.
[Cell Reports] |
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| Researchers demonstrated that loss of DEAD-box Helicase 41 (ddx41) led to anemia caused by diminished proliferation and defective differentiation of erythroid progenitors.
[Haematologica] |
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| Investigators showed that in vivo flux experiments that came from different laboratories could all be reconciled into a single unifying model, even though they had previously been interpreted as being contradictory.
[Stem Cell Reports] |
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| Scientists showed that Jak3 was expressed in endothelial cells across hematopoietic and non-hematopoietic organs, with heightened expression in the bone marrow.
[Communications Biology] |
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| Loss of Setd2 in hematopoietic cells ablated methyltransferase for histone 3 lysine-36 trimethylation, and led to anemia with a significant decrease in erythroid cells in the peripheral blood at E18.5.
[Biochemical and Biophysical Research Communications] |
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| The authors evaluated the effect of co-transplantation of bone marrow-derived MSC with HSCs on the liver fibrosis alleviation and transplant outcomes in class III beta-thalassemia major.
[Stem Cell Research & Therapy] |
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| Sequential waves of definitive hematopoiesis arise from yolk sac and intembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition.
[Angiogenesis] |
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| While acute myeloid leukemia represents an intuitive disease in which to investigate chimeric antigen receptor (CAR) based immunotherapies, key biological differences to B-cell malignancies have complicated progress to date.
[Cancers] |
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| WPD Pharmaceuticals Inc. announced that is has entered into an amended and restated sublicense agreement with Moleculin Biotech, Inc.
[WPD Pharmaceuticals, Inc.] |
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| Rafael Pharmaceuticals, Inc. announced that it has crossed the enrollment of 150 patients in its Phase III clinical trial for patients with relapsed or refractory AML.
[Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] |
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| April 19 – 23, 2021
Virtual |
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| | University of Washington – Seattle, Washington, United States |
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| | Moores Cancer Center – La Jolla, California, United States |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | City of Hope – Los Angeles, California, United States |
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