Hematopoiesis News Volume 12.15 | Apr 27 2021

May 12, 2022

2021-04-27 | HN 12.15

Hematopoiesis News by STEMCELL Technologies

Vol. 12.15 – 27 April, 2021

TOP STORY

iPSC Modeling of Stage-Specific Leukemogenesis Reveals BAALC as a Key Oncogene in Severe Congenital Neutropenia

Researchers established a model of stepwise leukemogenesis in congenital neutropenia (CN)/acute myeloid leukemiausing CRISPR-Cas9 gene editing of CN patient-derived iPSCs.
[Cell Stem Cell]

Abstract Graphical Abstract

Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.

PUBLICATIONSRanked by the impact factor of the journal

Targeting the Metabolic Vulnerability of Acute Myeloid Leukemia Blasts with a Combination of Venetoclax and 8-Chloro-Adenosine

Using acute myleoid leukemia cell lines (AML) and leukemia stem cell-enriched blast cells from pre-treatment AML patients, investigators evaluated the effects of 8-chloro-adenosine (8-Cl-Ado), VEN and the 8-Cl-Ado/venetoclax combination on fatty acid metabolism, glycolysis and oxidative phosphorylation using liquid scintillation counting, a Seahorse XF Analyzer and gene set enrichment analysis.
[Journal of Hematology & Oncology]

Full Article

Whole-Genome Sequencing Association Analysis of Quantitative Red Blood Cell Phenotypes: The NHLBI TOPMed Program

Researchers discovered 14 single variant-red blood cell trait associations at 12 genomic loci, which have not been reported previously.
[American Journal of Human Genetics]

Abstract Editorial

Bone Marrow Mesenchymal Stromal Cells Can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis

Scientists investigated the significance of the mode of immune-escape on T cells engineered to express chimeric antigen receptors (CAR-T) cells.
[Clinical Cancer Research]

Abstract

Palladium Nanoparticle-Induced Oxidative Stress, Endoplasmic Reticulum Stress, Apoptosis, and Immunomodulation Enhance the Biogenesis and Release of Exosome in Human Leukemia Monocytic Cells (THP-1)

Exosomes were isolated by ultracentrifugation and ExoQuick^TM and characterized by dynamic light scattering, nanoparticle tracking analysis system, scanning electron microscopy, transmission electron microscopy, EXOCET^TM assay, and fluorescence polarization.
[International Journal of Nanomedicine]

Full Article

Chromatin Occupancy and Target Genes of the Hematopoietic Master Transcription Factor MYB

Investigators performed a ChIP-seq analysis of MYB in K562 cells accompanied by detailed bioinformatics analyses. They found that MYB occupied both promoters and enhancers.
[Scientific Reports]

Full Article

High-Throughput Enrichment and Isolation of Megakaryocyte Progenitor Cells from the Mouse Bone Marrow

Researchers present a high throughput strategy for identifying and isolating megakaryocytes and their progenitor cells from a heterogeneous population of bone marrow samples.
[Scientific Reports]

Full Article

Human Hematopoietic Microenvironments

The authors characterized the human HSCs and progenitor microenvironment. They obtained three adjacent bone marrow sections from ten healthy volunteers.
[PLoS One]

Full Article

CLINICAL RESEARCH

Musculoskeletal Impairments in Children Receiving Intensive Therapy for Acute Leukemia or Undergoing Hematopoietic Stem Cell Transplant: A Report from the Children’s Oncology Group

Children with acute myeloid leukemia, relapsed acute lymphoblastic leukemia, or undergoing HSC transplant were systematically assessed for musculoskeletal impairments as part of Children’s Oncology Group study ACCL0934.
[Pediatric Blood & Cancer]

Abstract

Image of man completing the on-demand CFU assay course on his laptop.

REVIEWS

An Evolutionary Approach to Clonally Complex Hematologic Disorders

Investigators review the evidence within the hematologic malignancy field and also borrow from perspectives rooted in evolutionary biology to reframe pathogenesis of hematologic disorders as dynamic processes involving complex interplays of genetic and nongenetic subclones and the tissue microenvironment in which they reside.
[Blood Cancer Discovery]

Abstract

INDUSTRY AND POLICY NEWS

Ayala Pharmaceuticals Announces First Patient Dosed in Phase I Clinical Trial of AL102 in Combination with BCMA Targeting Agent, WVT078, in Patients with Relapsed/Refractory Multiple Myeloma

Ayala Pharmaceuticals, Inc. announced the dosing of the first patient in the ongoing Phase I clinical trial evaluating its potent investigational gamma secretase inhibitor, AL102, in combination with Novartis’ investigational anti-B-cell maturation antigen (BMSA) agent, WVT078, for the treatment of patients with relapsed and/or refractory multiple myeloma.
[Ayala Pharmaceuticals, Inc.]

Press Release

Bristol Myers Squibb Receives Positive CHMP Opinion for Onureg^® (Azacitidine Tablets; CC-486) as Frontline Oral Maintenance Therapy for Adults with Acute Myeloid Leukemia in First Remission

Bristol Myers Squibb announced the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended approval of Onureg^® as a maintenance therapy in adult patients with acute myeloid leukemia who achieved complete remission or complete remission with incomplete blood count recovery following induction therapy with or without consolidation treatment and who are not candidates for, including those who choose not to proceed to, HSC transplantation.
[Bristol Myers Squibb]

Press Release

Shorla Pharma Announces FDA Filing Acceptance and Priority Review for T-Cell Leukemia Treatment

Shorla Pharma Limited announced that it has submitted, and the FDA has accepted for filing, its application for its SH-111 oncology drug designed to treat T-cell leukemia.
[Shorla Pharma Limited (BusinessWire, Inc.)]

Press Release

FEATURED EVENT

iPSC Modeling of Stage-Specific Leukemogenesis Reveals BAALC as a Key Oncogene in Severe Congenital Neutropenia

Targeting the Metabolic Vulnerability of Acute Myeloid Leukemia Blasts with a Combination of Venetoclax and 8-Chloro-Adenosine

Whole-Genome Sequencing Association Analysis of Quantitative Red Blood Cell Phenotypes: The NHLBI TOPMed Program

Bone Marrow Mesenchymal Stromal Cells Can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis

Palladium Nanoparticle-Induced Oxidative Stress, Endoplasmic Reticulum Stress, Apoptosis, and Immunomodulation Enhance the Biogenesis and Release of Exosome in Human Leukemia Monocytic Cells (THP-1)

Chromatin Occupancy and Target Genes of the Hematopoietic Master Transcription Factor MYB

High-Throughput Enrichment and Isolation of Megakaryocyte Progenitor Cells from the Mouse Bone Marrow

Human Hematopoietic Microenvironments

Musculoskeletal Impairments in Children Receiving Intensive Therapy for Acute Leukemia or Undergoing Hematopoietic Stem Cell Transplant: A Report from the Children’s Oncology Group

An Evolutionary Approach to Clonally Complex Hematologic Disorders

Ayala Pharmaceuticals Announces First Patient Dosed in Phase I Clinical Trial of AL102 in Combination with BCMA Targeting Agent, WVT078, in Patients with Relapsed/Refractory Multiple Myeloma

Bristol Myers Squibb Receives Positive CHMP Opinion for Onureg^® (Azacitidine Tablets; CC-486) as Frontline Oral Maintenance Therapy for Adults with Acute Myeloid Leukemia in First Remission

Shorla Pharma Announces FDA Filing Acceptance and Priority Review for T-Cell Leukemia Treatment

Myeloid Cells: From Development to Function and Dysfunction

> See All Events

Postdoctoral Researcher Fellowships – Center for Stem Cell and Regenerative Medicine

Senior Postdoctoral Scientist – AML and Related Cancers

Research Scientist – Cancer Flow Cytometry

Postdoctoral Fellow or Research Scientist – Cell and Gene Therapy of Cancer

Journal Editor – Blood Cancer Discovery and Cancer Immunology

> See All Jobs