Hematopoiesis News Volume 12.17 | May 11 2021

    By
    Justin.choi
    -
    0
    172






    HN 12.17 | May 11 2021


    Hematopoiesis News by STEMCELL Technologies
    Vol. 12.17 – 11 May, 2021
    TOP STORY

    A Latent Subset of Human Hematopoietic Stem Cells Resists Regenerative Stress to Preserve Stemness

    Scientists identified distinct subsets of human long-term-HSCs that responded differently to regeneration-mediated stress: an immune checkpoint ligand CD112lo subset that exhibited a transient engraftment restraint before contributing to hematopoietic reconstitution and a primed CD112hi subset that responded rapidly.
    [Nature Immunology]

    Abstract

    Derive and expand human endothelial cells with EC-Cultâ„¢-XF Culture Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    Nicotinamide Riboside Attenuates Age-Associated Metabolic and Functional Changes in Hematopoietic Stem Cells

    Researchers showed that nicotinamide riboside, a form of vitamin B3, restored youthful metabolic capacity by modifying mitochondrial function in multiple ways.
    [Nature Communications]

    Full Article

    C/EBPβ Is a MYB- and p300-Cooperating Pro-Leukemogenic Factor and Promising Drug Target in Acute Myeloid Leukemia

    The authors characterized a group of natural sesquiterpene lactones, previously shown to suppress MYB activity, for their potential to decrease AML cell proliferation.
    [Oncogene]

    Full Article

    MAP-Kinase and JAK-STAT Pathways Dysregulation in Plasmablastic Lymphoma

    Scientists investigated thirty-four plasmablastic lymphoma using an integrated approach, including fluorescence in situ hybridization, targeted sequencing of 94 B-cell lymphoma related genes, and copy-number arrays.
    [Haematologica]

    Abstract

    IL4 Promotes Phagocytosis of Murine Leukemia Cells Counteracted by CD47 Upregulation

    Researchers investigated whether interleukin 4 (IL4) had antileukemic activity via immune-mediated mechanisms in an in vivo murine model of acute myeloid leukemia driven by the MLL–AF9 fusion gene.
    [Haematologica]

    Abstract

    Hematopoietic Stem Cells Retain Functional Potential and Molecular Identity in Hibernation Cultures

    The authors describe a powerful seven day HSC hibernation culture system that maintained HSCs as single cells in the absence of a physical niche.
    [Stem Cell Reports]

    Full Article

    Suppression of USP7 Induces BCR-ABL Degradation and Chronic Myelogenous Leukemia Cell Apoptosis

    Researchers found the antimalarial artesunate significantly inhibited ubiquitin-specific protease 7 (USP7)/BCR-ABL interaction, thereby promoting BCR-ABL degradation and inducing chronic myelogenous leukemia cell death.
    [Cell Death & Disease]

    Full Article

    Non-Genotoxic Conditioning Facilitates Hematopoietic Stem Cell Gene Therapy for Hemophilia A Using Bioengineered Factor VIII

    Scientists described a non-genotoxic conditioning protocol using an immunotoxin targeting CD117 to achieve endogenous HSC depletion and a cocktail of monoclonal antibodies to provide transient immune suppression against the transgene product in a murine hemophilia A gene therapy model.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    miR-204-5p and Platelet Function Regulation: Insight into a Mechanism Mediated by CDC42 and GPIIbIIIa

    Human HSCs were differentiated into megakaryocytes, enabling the transfection of miR-204-5p and the recovery of subsequent platelet-like structures.
    [Thrombosis and Haemostasis]

    Abstract

    Leukemia Stemness and Co-Occurring Mutations Drive Resistance to IDH Inhibitors in Acute Myeloid Leukemia

    Scientists performed multipronged genomic analyses in longitudinally collected specimens from 60 isocitrate dehydrogenase 1 (IDH1)- or IDH2-mutant AML patients treated with the inhibitors.
    [Nature Communications]

    Full Article

    Clinical Outcomes in Patients with Multi-Hit TP53 Chronic Lymphocytic Leukemia Treated with Ibrutinib

    The authors performed deep sequencing of TP53 using baseline samples collected from 51 TP53 aberrant patients treated with ibrutinib in a Phase II study.
    [Clinical Cancer Research]

    Abstract

    Distinct Immune Signatures in Chronic Lymphocytic Leukemia and Richter Syndrome

    Investigators analyzed expression of immune checkpoint molecules and infiltration of immune cells in nodal samples, and peripheral blood T-cell diversity in 33 chronic lymphocytic leukemia and 37 Richter syndrome patients.
    [Blood Cancer Journal]

    Full Article

    Learn about the applications of the CFU assay in toxicity testing from hematopoietic expert Dr. Jackie Damen.
    REVIEWS

    T-Cell-Based Immunotherapy of Acute Myeloid Leukemia: Current Concepts and Future Developments

    The stellar successes of immunotherapies that harness the power of T cells to treat solid tumors and an improved understanding of the immune systems of patients with hematologic malignancies have led to major efforts to develop immunotherapies for the treatment of patients with AML.
    [Leukemia]

    Full Article

    Hypomethylating Agents (HMA) for the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes: Mechanisms of Resistance and Novel HMA-Based Therapies

    The authors provide insights into the mode of action of HMA, mechanisms of resistance to this treatment, and strategies to overcome HMA resistance including next-generation HMA and HMA-based combination therapies.
    [Leukemia]

    Full Article

    INDUSTRY AND POLICY NEWS

    Precipio Launches New HemeScreen Panel for AML, with an Unparalleled 4-Hour Turnaround-Time

    Precipio, Inc. announced that it has launched a new, four-hour acute myeloid leukemia (AML) HemeScreen panel to specifically determine the genetics of this aggressive, acute form of leukemia.
    [Precipio, Inc. (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    Cell & Gene Therapy 2021

    May 18 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Cell Therapy

    Astellas Pharma – Westborough, Massachusetts, United States

    Senior Scientist – Hematopoiesis and Blood Diseases

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Research Associate / Postdoc – Histone Methyltransferases in Hematopoiesis

    Technische Universität Dresden – Dresden, Germany

    Postdoctoral Researcher Fellowships – Center for Stem Cell and Regenerative Medicine

    Zhejiang University – Zhejiang, China

    Senior Postdoctoral Scientist – AML and Related Cancers

    Cyprus Cancer Research Institute – Cyprus Republic

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Hematopoiesis News Twitter