 | | Vol. 12.23 – 15 June, 2021 |
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| The authors described a distinct subgroup of acute leukemia with expression of myeloid, T lymphoid, and stem cell markers driven by aberrant allele-specific deregulation of BCL11B, a master transcription factor responsible for thymic T-lineage commitment and specification.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers employed mitochondrial single-cell assay for transposase-accessible chromatin with sequencing to profile 163,279 cells from nine patients with chronic lymphocytic leukemia collected across disease course and utilized mitochondrial DNA mutations as natural genetic markers of cancer clones.
[Cancer Discovery] |
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| Investigators discovered that internal tandem duplication within FLT3 (FLT3-ITD), one of the most frequent mutations in acute myeloid leukemia, was S-palmitoylated by the ZDHHC6 palmitoyl acyltransferase. Disruption of palmitoylation redirected FLT3-ITD to the plasma membrane and rewired its downstream signaling by activating AKT and ERK pathways in addition to STAT5.
[Blood] |
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| To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.
[Science Translational Medicine] |
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| Researchers hypothesized that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signaling pathway may have been leveraged to trigger chronic lymphocytic leukemia cell death.
[Nature Communications] |
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| The authors described their development of cell culture techniques for the enrichment of functional hematopoietic stem and progenitor cells from mouse bone marrow without the use of fluorescence-activated cell sorting purification.
[Nature Communications] |
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| Scientists showed that Fanconi anemia (FA)-mutated cells were hypersensitive to persistent replication stress and that FA proteins played a role in the break-induced-replication-like pathway for fork restart.
[Nature Structural & Molecular Biology] |
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| By exploring the role of STAT3 in altering metabolism, researchers provided insight into identifying potential therapeutic targets for eliminating tyrosine kinase inhibitor-persistent leukemic stem cells.
[Leukemia] |
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| Investigators showed that gilteritinib and CUDC-907, a dual inhibitor of PI3K and histone deacetylases, synergistically induced apoptosis in FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) acute myeloid leukemia (AML) cell lines and primary patient samples and had striking in vivo efficacy.
[Blood Cancer Journal] |
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| Scientists conducted a multicenter biologic assignment trial comparing reduced-intensity hematopoietic cell transplantation to hypomethylating therapy or best supportive care in subjects 50-75 years of age with intermediate-2 or high-risk de novo myelodysplastic syndromes.
[Journal of Clinical Oncology] |
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| The authors analyzed Polycomb Repressor Complex 2 (PRC2) alterations in a large series of 218 adult T-cell acute lymphoblastic leukemia (T-ALL) patients and found that PRC2 genetic lesions were frequent events in T-ALL and were not restricted to ETP-ALL.
[Blood] |
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| Researchers conducted a cohort study to examine whether there was an association between diet quality and the prevalence of clonal hematopoiesis of indeterminate potential.
[JAMA Cardiology] |
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| Investigators compared 32 patients who underwent unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period.
[Bone Marrow Transplantation] |
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| The authors review the historical basis underpinning the development of allogeneic hematopoietic stem cell transplantation (allo-HSCT) as well as advances in knowledge obtained by defining mechanisms of allo-HSCT activity.
[Cancer Research] |
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| Investigators provide a novel therapeutic rationale for co-targeting eukaryotic initiation factor 4A (eIF4A) and FLT3 to address the clinical challenge of treating FLT3-mutant acute myeloid leukemia.
[Leukemia] |
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| Scientists highlight research describing the extant human CD164 monoclonal antibody characteristics, which are critical for identifying and purifying both human hematopoietic and skeletal stem cells.
[NPJ Regenerative Medicine] |
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| Bristol Myers Squibb announced positive results from TRANSFORM, a Phase III study evaluating Breyanzi as a second-line treatment in adults with relapsed or refractory large B-cell lymphoma compared to salvage therapy followed by high-dose chemotherapy and hematopoietic stem cell transplant.
[Bristol Myers Squibb] |
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| Global Blood Therapeutics, Inc. has awarded approximately $450,000 to US community-based organizations and institutions as part of the company’s 2021 Access to Excellent Care for Sickle Cell Patients (ACCEL) Grant Program. The program provides support to accelerate the development of sustainable access-to-care programs for people living with sickle cell disease.
[Global Blood Therapeutic, Inc.] |
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| June 21 – 24, 2021
Virtual |
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| | University of Wisconsin Madison – Madison, Wisconsin, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | UT Southwestern Medical Center – Dallas, Texas, United Statess |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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