Hematopoiesis News Volume 12.30 | August 3 2021

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    2021-08-03 | HN 12.30


    Hematopoiesis News by STEMCELL Technologies
    Vol. 12.30 – 3 August, 2021
    TOP STORY

    TFEB-Mediated Endolysosomal Activity Controls Human Hematopoietic Stem Cell Fate

    Researchers showed that lysosomes were regulated dichotomously by transcription factor EB (TFEB) and MYC to balance catabolic and anabolic processes required for activating long-term-HSCs and guiding their lineage fate.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    Breakthroughs take time. Isolating the right cells shouldn't. Learn more.
    PUBLICATIONSRanked by the impact factor of the journal

    Identification of HSC/MPP Expansion Units in Fetal Liver by Single-Cell Spatiotemporal Transcriptomics

    Scientists constructed a spatiotemporal transcriptome map of mouse fetal liver as a platform for experimental validation of novel regulatory mechanisms underlying HSC and multipotent progenitor expansion.
    [Cell Research]

    Abstract

    Asymmetric Organelle Inheritance Predicts Human Blood Stem Cell Fate

    The authors used long-term quantitative single-cell imaging to show that lysosomes and active mitochondria were asymmetrically inherited in human blood stem cells and that their inheritance was a coordinated, non-random process.
    [Blood]

    Abstract

    Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL

    In vitro treatment of Idh2R140Q/NHD13 thymocytes with enasidenib, a selective inhibitor of mutant IDH2, led to a marked decrease in leukemic cell proliferation, demonstrating that Idh2R140Q/NHD13 mice could serve as a useful in vivo model for the study of early/immature T cell precursor acute lymphoid leukemia (ALL) development and therapy.
    [Cancer Research]

    Abstract

    The RNA-Binding Protein IGF2BP3 Is Critical for MLL-AF4-Mediated Leukemogenesis

    Researchers found that the RNA-binding protein IGF2BP3, which was overexpressed in mixed-lineage leukemia (MLL)-translocated leukemia, strongly amplified MLL-Af4-mediated leukemogenesis.
    [Leukemia]

    Full Article

    IL-6 Generated from Human Hematopoietic Stem and Progenitor Cells through TLR4 Signaling Promotes Emergency Granulopoiesis by Regulating Transcription Factor Expression

    Investigators reported that TLR4 was expressed on granulo-monocytic progenitors, as well as mobilized human peripheral blood CD34+ cells. LPS, a component of Gram-negative bacteria that results in a systemic bacterial infection, induced the differentiation of peripheral blood CD34+ cells into myelocytes and monocytes in vitro via the TLR4 signaling pathway.
    [Journal of Immunology]

    Abstract

    Recapitulative Hematopoietic Development of Human Pluripotent Stem Cells in the Absence of Exogenous Hematopoietic Cytokines

    Scientists showed that endogenous stimuli and VEGF were sufficient to induce robust human pluripotent stem cell-derived hematopoiesis, intensive generation of hematopoietic progenitors, maturation of blood cells and the emergence of definitive precursor cells including those that were phenotypically identical to early human embryonic HSCs.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    The BET Bromodomain Inhibitor ZEN-3365 Targets the Hedgehog Signaling Pathway in Acute Myeloid Leukemia

    The authors investigated the effect of ZEN-3365, a novel BRD4 inhibitor, on acute myeloid leukemia cells in regard to the Hedgehog pathway.
    [Annals of Hematology]

    Full Article

    Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial

    In this single-center, Phase I trial, researchers administered anti-CD7 CAR T cells, manufactured from either previous stem cell transplantation donors or new donors to patients with relapsed or refractory T cell acute lymphoblastic leukemia
    [Journal of Clinical Oncology]

    Abstract

    CEBPA Mutations in 4708 Patients with Acute Myeloid Leukemia – Differential Impact of bZIP and TAD Mutations on Outcome

    Investigators analyzed 4708 adult acute myeloid leukemia patients recruited into Study Alliance Leukemia trials to investigate the prognostic impact of CEBPAsm.
    [Blood]

    Abstract

    Pharmacodynamic, Pharmacokinetic, and Phase Ia Study of Bisthianostat, a Novel Histone Deacetylase Inhibitor, for the Treatment of Relapsed or Refractory Multiple Myeloma

    Bisthianostat dose dependently induced acetylation of tubulin and H3 and increased PARP cleavage and apoptosis in RPMI-8226 cells. In RPMI-8226 and MM.1S cell xenograft mouse models, oral administration of bisthianostat for 18 days dose dependently inhibited tumor growth.
    [Acta Pharmacologica Sinica]

    Full Article

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    REVIEWS

    AML1/ETO and Its Function as a Regulator of Gene Transcription via Epigenetic Mechanisms

    The authors describe the wide-ranging role of AML1/ETO in acute myeloid leukemia (AML) leukemogenesis, with a particular focus on the aberrant epigenetic regulation of gene transcription driven by this AML-defining mutation.
    [Oncogene]

    Full Article

    INDUSTRY AND POLICY NEWS

    Kronos Bio Announces FDA Clearance of Investigational New Drug Application for Lanraplenib (LANRA) for Treatment of Patients with Acute Myeloid Leukemia (AML)

    Kronos Bio, Inc. announced the US FDA has cleared its Investigational New Drug Application for LANRA, allowing the company to proceed with a Phase I/II clinical trial of LANRA in patients with relapsed or refractory FLT3-mutated AML in combination with gilteritinib.
    [Kronos Bio, Inc.]

    Press Release

    FEATURED EVENT

    Acute Myeloid Leukemia and Myelodysplastic Syndrome

    February 17 – 20, 2022
    Austin, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer Genomics and Liquid Biopsies

    University of Gothenburg – Gothenburg, Sweden

    Assistant Professor – Translational Metabolism

    Dalhousie University – Halifax, Nova Scotia, Canada

    Postdoctoral Researcher – CRISPR/Cas9 and Hematopoietic Stem Cell Biology

    Aarhus University – Aarhus, Denmark

    Postdoctoral Researcher – Stem Cells and Immunotherapy

    University of Wisconsin-Madison – Madison, Wisconsin, United States

    PhD Student – Targeted Leukemia Prevention

    Heinrich Heine University Düsseldorf – Düsseldorf, Germany

    > See All Jobs

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