 | | Vol. 12.35 – 7 September, 2021 |
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| Hematopoietic progenitor cells with biallelic frameshift and R525H mutations underwent cell cycle arrest and apoptosis, causing bone marrow failure in mice. Mechanistically, DDX41 was essential for small nucleolar RNA processing, ribosome assembly, and protein synthesis.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that CUX1 had a critical early role in the DNA repair process in hematopoietic stem and progenitor cells. Mechanistically, CUX1 recruited the histone methyltransferase EHMT2 to DNA breaks to promote downstream H3K9 and H3K27 methylation, phosphorylated ATM retention, subsequent γH2AX focus formation and propagation, and, ultimately, 53BP1 recruitment.
[Blood] |
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| Researchers reported that INTS11 was required for normal hematopoiesis and hematopoietic-specific genetic deletion of Ints11 led to cell cycle arrest and impairment of fetal and adult hematopoietic stem and progenitor cells.
[Science Advances] |
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| The authors proposed a personalized approach by using patient blood–derivable biomaterials as the main construction fabric of wireless medical micromachines to alleviate safety risks from biocompatibility.
[Science Advances] |
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| Using live imaging of calcium signaling in intact lymph glands, investigators found that blood progenitors were connected through a signaling network. Blocking gap junction function disrupted this network, altered the pattern of encoded calcium signals, and led to loss of progenitors and precocious blood cell differentiation.
[Current Biology] |
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| Scientists reported that ubiquitin-specific peptidase 15 (USP15) mRNA and protein were overexpressed in human acute myeloid leukemia as compared to normal hematopoietic progenitor cells.
[Leukemia] |
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| Competitive transplantations of Jak2V617F versus wild-type bone marrow showed that ERK1/2 deficiency in hematopoiesis mitigated MPN features and reduced the Jak2V617F clone in blood and hematopoietic progenitor compartments.
[Leukemia] |
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| Using a Thpo translational reporter, researchers found that the liver but not the bone marrow was the major source of thrombopoietin protein after myeloablation. Mice with conditional Thpo deletion from hepatocytes showed significant defects in hematopoietic stem cell regeneration and hematopoietic rebound after myeloablation.
[eLife] |
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| The authors found that pharmacologic inhibition of neddylation using a small-molecule inhibitor, MLN4924/Pevonedistat, increased the expression of the natural killer (NK) cell-activating receptor NKG2D ligands MICA and MICB on the plasma membrane of different multiple myeloma cell lines and patient-derived plasma cells, leading to enhanced NK cell degranulation.
[Cell Death & Disease] |
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| Investigators conducted a single-center Phase I dose-escalation study with lenalidomide maintenance in high-risk myelodysplastic syndrome and acute myeloid leukemia patients after allogeneic transplantation.
[Bone Marrow Transplantation] |
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| Scientists reported the intensive bone marrow monitoring of minimal residual disease using flow cytometry and nested reverse transcription polymerase chain reaction (PCR) whenever a fusion transcript allowed it and chimerism by PCR at eleven timepoints in the first two years after transplant.
[Bone Marrow Transplantation] |
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| Researchers showed that tolinapant acted as an efficacious immunomodulatory molecule capable of inducing complete tumor regression in a syngeneic model of T cell lymphoma exclusively in the presence of an intact immune system.
[Blood Advances] |
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| Investigators demonstrated the relevance of genetic germline diagnostics in elucidating the causes of myeloproliferative neoplasms (MPNs) and suggested novel therapeutic options in MPNs.
[Blood Advances] |
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| Scientists summarize current advances and knowledge of long non-coding RNAs (lncRNAs) in gene regulation, focusing on the recent progresses on the role of lncRNAs in CTCF/cohesin mediated 3D genome organization, and how such genome folding signals in turn regulate transcription, hematopoietic stem and progenitor cell function and transformation.
[Blood] |
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| The authors synthesize studies characterizing myeloid cell leukemia-1 (MCL1)’s influence on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that MCL1 plays in cellular homeostasis regulation.
[Communications Biology] |
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| Global Blood Therapeutics, Inc. announced that the US FDA has accepted for filing and review the company’s supplemental New Drug Application seeking accelerated approval for Oxbryta® for the treatment of sickle cell disease in children ages 4 to 11 years and its New Drug Application seeking approval for a new age-appropriate dispersible tablet dosage form of Oxbryta suitable for pediatric patients.
[Global Blood Therapeutics, Inc.] |
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| October 19 – 20, 2021
Virtual |
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| | University Hospital of Bern – Bern, Switzerland |
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| | Banner MD Anderson Cancer Center – Gilbert, Arizona, United States |
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| | Sidney Kimmel Cancer Center at Jefferson Health – Philadelphia, Pennsylvania, United States |
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| | Indiana University – Indianapolis, Indiana, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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