Hematopoiesis News Volume 12.44 | Nov 9 2021

    By
    Justin.choi
    -
    0
    160







    2021-11-09 | HN 12.44


    Hematopoiesis News by STEMCELL Technologies
    Vol. 12.44 – 9 November, 2021
    TOP STORY

    Resistance to Inflammation Underlies Enhanced Fitness in Clonal Hematopoiesis

    Researchers developed a technique that combined mosaic mutagenesis with color labeling of hematopoietic stem and progenitor cells to study how acquired mutations affected clonal fitness in a native environment.
    [Science]

    Abstract

    Banner Ad Cross Reference Banner Ad Cross Reference 100% 10 E17 Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions. Screen reader support enabled. Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions. Turn on screen reader support
    PUBLICATIONSRanked by the impact factor of the journal

    Rare t(X; 14)(q28; q32) Translocation Reveals Link between MTCP1 and Chronic Lymphocytic Leukemia

    Scientists reported overexpression of human mature T cell proliferation 1 gene (MTCP1) restricted to the B cell compartment in mice produced a clonal CD5+/CD19+ leukemia recapitulating the major characteristics of human chronic lymphocytic leukemia.
    [Nature Communications]

    Full Article

    The IL-3, IL-5, and GM-CSF Common Receptor Beta Chain Mediates Oncogenic Activity of FLT3-ITD-Positive AML

    The authors discovered that FMS-like Tyrosine Kinase 3 (FLT3)-internal tandem duplication (ITD) directly bound to CSF2RB in acute myeloid leukemia (AML) cell lines and blasts isolated from AML patients.
    [Leukemia]

    Full Article

    The GPI-Anchored Protein CD109 Protects Hematopoietic Progenitor Cells from Undergoing Erythroid Differentiation Induced by TGF-β

    Investigators found that CD109 suppressed TGF-β signaling in hematopoietic stem progenitor cells (HSPCs), and increased the sensitivity of PIGA-mutated HSPCs to TGF-β, leading to the preferential commitment of erythroid progenitor cells to mature red blood cells.
    [Leukemia]

    Abstract

    Cancer Drivers and Clonal Dynamics in Acute Lymphoblastic Leukemia Subtypes

    To obtain a comprehensive picture of composite genetic driver events and clonal dynamics in subtypes of pediatric acute lymphoblastic leukemia, scientists analyzed tumor-normal whole genome sequencing and expression data from 361 newly diagnosed patients.
    [Blood Cancer Journal]

    Full Article

    Transducin β-Like Protein 1 Controls Multiple Oncogenic Networks in Diffuse Large B Cell Lymphoma

    The authors showed that, unlike normal B cells, diffuse large B cell lymphoma (DLBCL) cells expressed abundant levels of transducin b-like protein 1 and its overexpression correlated with poor clinical outcome regardless of DLBCL molecular subtype.
    [Haematologica]

    Full Article

    TCP1 Increases Drug Resistance in Acute Myeloid Leukemia by Suppressing Autophagy via Activating AKT/mTOR Signaling

    Scientists discovered that the T-complex protein 1 (TCP1) expression was elevated in acute myeloid leukemia patients and high TCP1 expression was associated with low complete response rate along with poor overall survival.
    [Cell Death & Disease]

    Full Article

    Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

    Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease–related morbidity and mortality. Researchers found that CHIP was associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke.
    [Stroke]

    AbstractFull ArticleGraphical Abstract

    Long-Term Survival with Mixed Chimerism in Patients with AML and MDS Transplanted after Conditioning with Targeted Busulfan, Fludarabine, and Thymoglobulin

    The authors evaluated long-term outcomes in 40 patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), transplanted from related or unrelated donors following conditioning with targeted busulfan, fludarabine, and thymoglobulin.
    [Bone Marrow Transplantation]

    Abstract
    Image of man completing the on-demand CFU assay course on his laptop.
    REVIEWS

    Opening the Window for Endothelial-to-Hematopoietic Transition

    Scientists highlight interesting parallels between endothelial-to-hematopoietic transition and endothelial-to-mesenchymal transition, which occurs during cardiac development.
    [Genes & Development]

    Abstract
    INDUSTRY AND POLICY NEWS

    Jasper Therapeutics Announces Research Collaboration with AVROBIO to Evaluate JSP191 as Conditioning Agent in Clinical Studies of Ex Vivo Lentiviral Gene Therapy

    Jasper Therapeutics, Inc. announced that it has entered into a non-exclusive research collaboration with AVROBIO, Inc. to evaluate the use of JSP191, Jasper’s anti-CD117 monoclonal antibody, as a targeted conditioning agent option for patients with Fabry disease and/or Gaucher disease type 1.
    [Jasper Therapeutics, Inc.]

    Press Release

    Cyclacel Announces Dosing of First Patient in Phase I/II Study of Oral Fadraciclib in Patients With Leukemias or Myelodysplastic Syndromes

    Cyclacel Pharmaceuticals, Inc. announced dosing of the first patient in the company’s multi-cohort Phase I/II study of oral fadraciclib in patients with leukemias or myelodysplastic syndromes.
    [Cyclacel Pharmaceuticals, Inc.]

    Press Release
    FEATURED EVENT

    ESMO Immuno-Oncology Congress

    December 8 – 11, 2021
    Geneva, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Hematologic Malignancies

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Position – Drug Resistance

    University Children’s Hospital Zurich – Zurich, Switzerland

    Postdoctoral Position – Gene Editing

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Fellow – Functional Genomics of Hematopoiesis

    Boston Children’s Hospital – Boston, Massachusetts, United States

    Assistant Professor – Cancer Research

    University of Manitoba – Winnipeg, Manitoba, Canada

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Hematopoiesis News Twitter