 | | Vol. 12.49 – 14 December, 2021 |
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| Scientists described conditionally pathogenic enhancer motif variants that differentially affected hematopoietic development and regeneration. Despite normal developmental hematopoiesis, regeneration in response to chemotherapy, inflammation, and a therapeutic HSC mobilizer was compromised.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, established a pre-leukemic stage in which B cell precursors displayed self-renewal ability, initiating leukemia resembling PAX5 P80R or Ph-like human B-acute lymphoblastic leukemia.
[Nature Communications] |
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| Investigators showed that inducible CD36 was required for free fatty acid uptake by HSCs during acute infection, allowing the metabolic transition from glycolysis towards β-oxidation.
[Nature Communications] |
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| Utilizing a Flt3-ITD knock-in, Dnmt3a haploinsufficient mouse model, researchers demonstrated that Gab2 was essential for the development of Flt3-ITD driven acute myeloid leukemia in vivo, as Gab2 deficient mice displayed prolonged survival.
[Leukemia] |
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| Investigators showed that in Ncx1−/− mouse embryos devoid of circulation, the HSC lineage developed until the phenotypic pro-HSC stage. Experimental activation of glycolysis resulted in decreased intraembryonic hematopoiesis.
[Cell Reports] |
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| The authors showed that cultured HSCs expressed mast cell-related genes including Cd244 and suggested CD244 was a potent marker to exclude non-functional HSCs after in vitro culture thereby useful to elucidate mechanism of functional decline of HSCs during ex vivo treatment.
[iScience] |
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| Researchers showed that in mice early-stage CD71+ erythroid cells expanded in anemia, had high levels of arginase 2 and reactive oxygen species.
[Communications Biology] |
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| The authors established inducible P18/hESC lines and monitored the effects of P18 overexpression on hematopoietic differentiation and found evidence that P18 promoted hematopoiesis, a rare property among cyclin-dependent kinase inhibitors.
[Scientific Reports] |
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| Scientists investigated the recommended dose for expansion of siremadlin, a p53-MDM2 inhibitor, in patients with wild-type TP53 advanced solid or hematologic cancers.
[Clinical Cancer Research] |
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| Investigators evaluated the effect of HU on immune profiles through a controlled prospective cohort study conducted in 30 children with sickle cell anemia and 30 healthy age-matched controls.
[Pediatric Research] |
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| The authors provide a clinical decision support tool for pediatric hematologists, oncologists, and critical care physicians during the difficult decision-making process of extracorporeal membrane oxygenation candidacy and management.
[Lancet Child & Adolescent Health] |
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| Scientists review relevant literature, considering endpoints of both survival and long term quality of life and retrospectively evaluate patients with metastatic germ cell tumor progressing after first-line treatment.
[Critical Reviews in Oncology Hematology] |
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| Mustang Bio, Inc. announced updated data from the ongoing Phase I/II clinical trial of MB-106, a CD20-targeted, autologous CAR T cell therapy for patients with relapsed or refractory B cell non-Hodgkin lymphomas and chronic lymphocytic leukemia.
[Mustang Bio, Inc.] |
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| January 23 – 26, 2022
Santa Fe, New Mexico, United States |
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| | Memorial Sloan Kettering – New York City, New York, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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