Hematopoiesis News Volume 13.03 | Jan 25 2022

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    Justin.choi
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    2022-01-25 | HN 13.03


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.03 – 25 January, 2022
    TOP STORY

    Subversion of Serotonin-Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia

    Scientists leveraged genetic mouse models, patient-derived xenografts, and patient samples to show that acute myeloid leukemia exploited peripheral serotonin-signaling to remodel the endosteal niche to its advantage.
    [Cancer Discovery]

    AbstractFull Article
    Request your free copy of the 'Frequencies of Cell Types in Human Peripheral Blood' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Unique Molecular and Functional Features of Extramedullary Hematopoietic Stem and Progenitor Cell Reservoirs in Humans

    Researchers comprehensively delineated human extramedullary hematopoietic stem and progenitor cell compartments comparing spleen, peripheral blood (PB) and mobilized PB to bone marrow using single-cell RNA-seq and/or functional assays.
    [Blood]

    Abstract

    SLAMF3 and SLAMF4 Are Immune Checkpoints That Constrain Macrophage Phagocytosis of Hematopoietic Tumors

    Investigators reported a critical role of SLAM family receptors, ubiquitously expressed on hematopoietic cells and forming homotypic interactions, in constraining macrophage phagocytosis.
    [Science Immunology]

    Full Article

    Clonal Evolution in Patients Developing Therapy-Related Myeloid Neoplasms Following Autologous Stem Cell Transplantation

    Clonal hematopoiesis was associated with increasing age and with a factor 6 increase in the risk of developing therapy-related myeloid neoplasms following autologous stem cell transplantation.
    [Bone Marrow Transplantation]

    Abstract

    Mechanical Phenotyping of Acute Promyelocytic Leukemia Reveals Unique Biomechanical Responses in Retinoic Acid-Resistant Populations

    Using mechano-node-pore sensing, a single-cell mechanical phenotyping platform, and patient-derived acute promyelocytic leukemia (APL) cell lines, scientists discovered that all-trans retinoic acid-resistant APL cells were less mechanically pliable.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Using Cryo-ET to Distinguish Platelets during Pre-Acute Myeloid Leukemia from Steady State Hematopoiesis

    Researchers demonstrated that platelets with structurally abnormal mitochondria emerged at the pre-leukemic phase of acute myeloid leukemia, preceding detectable changes in blood cell counts or detection of leukemic blasts in blood.
    [Communications Biology]

    Full Article

    Machine Learning Assisted Real-Time Deformability Cytometry of CD34+ Cells Allows to Identify Patients with Myelodysplastic Syndromes

    Investigators used real-time deformability cytometry to measure bone marrow biopsy samples of myelodysplastic syndrome patients and age-matched healthy individuals.
    [Scientific Reports]

    Full Article

    Pterostilbene Downregulates BCR/ABL and Induces Apoptosis of T315I-Mutated BCR/ABL-Positive Leukemic Cells

    Scientists examined the antileukemic effects of pterostilbene, a natural methylated polyphenol analog of resveratrol that is predominantly found in berries and nuts, using various human and murine leukemic cells, as well as bone marrow samples obtained from patients with leukemia.
    [Scientific Reports]

    Full Article

    Inhibition of MCL1 Induces Apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma

    To find additional hematologic entities with ectopic expression of BCL2 family members, the authors performed expression screening of cell lines applying the LL-100 panel.
    [Scientific Reports]

    Full Article

    The Association of Graft-Versus-Leukemia Effect and Graft-Versus Host Disease in Haploidentical Transplantation with Post-Transplant Cyclophosphamide for AML

    Investigators used a series of landmark analyses to investigate the association of graft-versus-host disease in the setting of haploidentical SCT (haploSCT) with post-transplant cyclophosphamide in 805 acute myeloid leukemia patients following haploSCT.
    [Bone Marrow Transplantation]

    Abstract
    Learn about the applications of the CFU assay in toxicity testing from hematopoietic expert Dr. Jackie Damen.
    REVIEWS

    Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications

    The authors review leukemia stem cell biology, particularly as it relates to the very heterogeneous nature of acute myeloid leukemia and to its high disease relapse rate.
    [Stem Cell Reviews and Reports]

    Abstract

    DNA Methylation: A Saga of Genome Maintenance in Hematological Perspective

    Scientists evaluate the spacio-temporal landscape expression and role of DNA methyltransferases during hematopoiesis, hematopoietic malignancy and HSCs transplantation.
    [Human Cell]

    Abstract
    INDUSTRY AND POLICY NEWS

    EdiGene Enters Strategic R&D Collaboration with Haihe Laboratory of Cell Ecosystem to Develop Hematopoietic Stem Cell Regenerative Therapies and Platform Technologies

    EdiGene, Inc. announced a research and development collaboration with Haihe Laboratory of Cell Ecosystem to develop HSC regenerative therapies and platform technology by combining resources and expertise from both sides.
    [EdiGene, Inc. (BusinessWire, Inc.)]

    Press Release

    HUTCHMED Receives Breakthrough Therapy Designation in China for HMPL-523 for Treatment of Primary Immune Thrombocytopenia

    HUTCHMED Limited announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation to HMPL-523, a novel, investigational spleen tyrosine kinase inhibitor, for the treatment of chronic adult primary immune thrombocytopenia patients who have received at least one prior therapy.
    [HUTCHMED Limited (Globe Newswire, Inc.)]

    Press Release
    FEATURED EVENT

    Nature Conference – Breaking Barriers for Gender Equity Through LEAP

    8 March, 2022
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scholar – Pediatric Hematology

    Penn State College of Medicine – Hershey, Pennsylvania, United States

    Faculty Position – Hematopathology

    University of Vermont – Burlington, Vermont, United States

    PhD Student – Chronic Lymphocytic Leukemia

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    Postdoctoral Positions – Clinical Proteomics

    University of Copenhagen – Copenhagen, Denmark

    Scientist – CART T Cell Cancer Immunotherapies

    Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States

    > See All Jobs

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