 | | Vol. 13.05 – 8 February, 2022 |
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| Through targeted sequencing in 5,008 patients, investigators identified a key regulatory germline variant in GATA3 associated with Philadelphia chromosome-like acute lymphoblastic leukemia.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed in Pax5+/- mice that transient, early-life administration of clinically relevant doses of ruxolitinib, a JAK1/2 inhibitor, significantly mitigated the risk of B cell acute lymphoblastic leukemia following exposure to infection.
[Cancer Research] |
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| Scientists characterized age-related phenotypes of human HSCs and reported increased frequencies of HSC, hematopoietic progenitor cells and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid progenitors.
[Haematologica] |
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| The authors revealed that the BC200/miR-150-5p/MYB positive feedback loop promoted the proliferation of myelodysplastic syndrome (MDS) cells and was expected to be a potential biomarker and therapeutic target in MDS.
[Cell Death & Disease] |
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| Investigators directed a study to deepen the effects of nutrient shortage on BCR/Ablprotein expression and signaling in chronic myeloid leukemia cells.
[Oncology Research] |
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| The authors found that Reh acute lymphoblastic leukemia cells bearing the KRAS-G12D mutation showed increased proliferation rates in vitro but displayed severely compromised growth in mice.
[iScience] |
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| Scientists investigated the effect of Bisphenol A and diethylhexyl phthalate on the clonogenic capacity of umbilical cord blood HSCs.
[Environmental Science and Pollution Research] |
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| Investigators performed targeted panel sequencing of paired diagnostic and first treatment evaluation samples in 69 patients with residual disease by morphology or measurable residual disease level >0.02.
[Experimental Hematology] |
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| Scientists reported the results of a prospective, single-arm, Phase II clinical trial done at the University Medical Center Utrecht and the Princess Máxima Center for Pediatric Oncology to investigate individualized dosing of anti-thymocyte globulin for unrelated allogeneic HSC transplantation in pediatric patients.
[Lancet Haematology] |
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| The authors systematically analyzed genetic alterations in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia uniformly treated in clinical trials with dasatinib-based regimens or a ponatinib-based regimen.
[Leukemia] |
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| Researchers provided insight into the relapsed or refractory (R/R) AML molecular profile and the impact of FLT3 inhibitors on mutational evolution associated with treatment resistance and benefit of gilteritinib across a wide spectrum of molecular and genetic subgroups in FLT3-mutated R/R AML.
[Blood Advances] |
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| The authors summarize current understanding of clonal hematopoiesis with a focus on cardiovascular disease and inflammation while outlining the potential, yet unexplored, relationship between clonal hematopoiesis and autoimmune disease.
[Seminars in Immunopathology] |
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| Scientists focus on the pharmacokinetics of approved tyrosine kinase inhibitors related to chronic myeloid leukemia therapy to comprehend their specificity, tolerability, and off-target effects.
[Molecular and Cellular Biochemistry] |
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| Seagen, Inc. announced that the Phase III ECHELON-1 clinical trial demonstrated a statistically significant improvement in overall survival in patients with advanced classical Hodgkin lymphoma following treatment with ADCETRIS in combination with chemotherapy.
[Seagen, Inc.] |
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| BioMarin’s gene therapy for hemophilia A is currently in development and not yet licensed by regulators. Speaker Prof Johnny Mahlangu reported an update from BioMarin’s ongoing Phase I/II study, namely that in November 2021, a single serious adverse event was reported in a patient from this study who had developed a lump in their neck, which was later diagnosed as salivary gland cancer.
[EHC News] |
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| March 19 – 23, 2022
Prague, Czech Republic & Online |
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| | George Mason University – Prince William, Virginia, United States |
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| | Stanford University – Stanford, California, United States |
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| | Penn State College of Medicine – Hershey, Pennsylvania, United States |
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| | University of Vermont – Burlington, Vermont, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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